American Journal of Physiology- Lung Cellular and Molecular Physiology No. 1. JULY 2001 INVITED REVIEW Molecular basis of hypoxia-induced pulmonary vasoconstriction: role of voltage-gated K* channels E. A. Coppock, J. R. Martens, and M. M. Tamkun SPECIAL TOPIC CFTR trafficking and signaling in respiratory epithelium B. R. Pitt Na* transport in normal and CF human bronchial epithelial cells is inhibited by BAY 39-9437 R. J. Bridges, B. B. Newton, J. M. Pilewski, D. C. Devor, C. T. Poll, and R. L. Hail Synthetic chloride channel restores glutathione secretion in cystic fibrosis airway epithelia L. Gao, J. R. Broughman, T. Iwamoto, J. M. Tomich, C. J. Venglarik, and H. J. Forman Antioxidant imbalance in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice L. W. Velsor, A. van Heeckeren, and B. J. Day EDITORIAL FOCUS Chaperoning the maturation of the cystic fibrosis transmembrane conductance regulator J. L. Brodsky Sodium 4-phenylbutyrate downregulates HSC70 expression by facilitating mRNA degradation R. C. Rubenstein and B. M. Lyons Partial restoration of defective chloride conductance in AF508 CF mice by trimethylamine oxide H. Fischer, N. Fukuda, P. Barbry, B. Illek, C. Sartori, and M. A. Matthay Induction of HSP70 promotes AF508 CFTR trafficking L. R. Choo-Kang and P. L. Zeitlin EDITORIAL FOCUS Dysregulated NF-«B activation in cystic fibrosis: evidence for a primary inflammatory disorder T. S. Blackwell, A. A. Stecenke, and J. W. Christman Activation of NF-«B in airway epithelial cells is dependent on CFTR trafficking and Cl~ channel function A. J. Weber, G. Soong, R. Bryan, S. Saba, and A. Prince Dopamine regulates Na-K-ATPase in alveolar epithelial cells via MAPK-ERK-dependent mechanisms C. Guerrero, E. Lecuona, L. Pesce, K. M. Ridge, and J. I. Sznajder Involvement of the MAP kinase ERK2 in MUC1 mucin signaling D. Meerzaman, P. S. Shapiro, and K. C. Kim IL-12 attenuates bleomycin-induced pulmonary fibrosis M. P. Keane, J. A. Belperio, M. D. Burdick, and R. M. Strieter Sphingomyelin metabolites inhibit sphingomyelin synthase and CTP:phosphocholine cytidylyltransferase J. Vivekananda, D. Smith, and R. J. King CTP:phosphocholine cytidylvltransferase inhibition by ceramide via PKC-a, p38 MAPK, cPLAg, and 5-lipoxygenase S. Awasthi, J. Vivekananda, V. Awasthi, D. Smith, and R. J. King Bacterial induction of pleural mesothelial monolayer barrier dysfunction K. A. Mohammed, N. Nasreen, J. Hardwick, C. S. Logie, C. E. Patterson, and V. B. Antony Effects of cyclopiazonic acid on cytosolic calcium in bovine airway smooth muscle cells M. F. Ethier, H. Yamaguchi, and J. M. Madison Evaluation of basement membrane degradation during TNF-a-induced increase in epithelial permeability J.-C. Lacherade, A. Van De Louw, E. Planus, E. Escudier, M.-P. D’Ortho, C. Lafuma, A. Harf, and C. Delclaux L134 Uptake of a natural surfactant and increased delivery of small organic anions into type II pneumocytes M. Griese, A. Baatz, J. Beck, and B. Deubzer Tyrosine kinase receptor activation inhibits NPR-C in lung arterial smooth muscle cells J.-Z. Sun, S. Oparil, P. Lucchesi, J. A. Thompson, and Y.-F. Chen L155 Bradykinin augments fibroblast-mediated contraction of released collagen gels T. Mio, X. Liu, M. L. Toews, Y. Adachi, D. J. Romberger, J. R. Spurzem, and S. I. Rennard Cellular response of antioxidant metalloproteins in Cu/Zn SOD transgenic mice exposed to hyperoxia M. A. Levy, Y.-H. Tsai, A. Reaume, and T. M. Bray Chronic hypoxia-induced spontaneous and rhythmic contractions in the rat main pulmonary artery S. Bonnet, J.-M. Hyvelin, P. Bonnet, R. Marthan, and J.-P. Savineau L183 Effect of chronic hypoxia on agonist-induced tone and calcium signaling in rat pulmonary artery S. Bonnet, A. Belus, J.-M. Hyvelin, E. Roux, R. Marthan, and J.-P. Savineau Partial HIF-1la deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia L. A. Shimoda, D. J. Manalo, J. S. K. Sham, G. L. Semenza, and J. T. Sylvester Carbon monoxide attenuates aeroallergen-induced inflammation in mice J. T. Chapman, L. E. Otterbein, J. A. Elias, and A. M. K. Choi Modulation of a-ENaC and a,;-Na*-K*-ATPase by cAMP and dexamethasone in alveolar epithelial cells A. Dagenais, C. Denis, M.-F. Vives, S. Girouard, C. Massé, T. Nguyen, T. Yamagata, C. Grygorczyk, R. Kothary, and Y. Berthiaume Surfactant protein interactions with neutral and acidic phospholipid films K. Rodriguez-Capote, K. Nag, S. Schiirch, and F. Possmayer Role of zinc in pulmonary endothelial cell response to oxidative stress Z.-L. Tang, K. Wasserloos, C. M. St. Croix, and B. R. Pitt Novel mechanisms in murine nitrofen-induced pulmonary hypoplasia: FGF-10 rescue in culture J. M. Acosta, B. Thébaud, C. Castillo, A. Mailleux, D. Tefft, C. Wuenschell, K. D. Anderson, J. Bourbon, J.-P. Thiery, S. Bellusci, and D. Warburton Regulation of murine airway responsiveness by endothelial nitric oxide synthase M. Feletou, M. Lonchampt, F. Coge, J.-P. Galizzi, C. Bassoullet, C. Merial, P. Robineau, J. A. Boutin, P. L. Huang, P. M. Vanhoutte, and E. Canet Enhanced clearance of surfactant protein D during LPS-induced acute inflammation in rat lung J. F. Herbein and J. R. Wright SPECIAL COMMUNICATION Nitric oxide modulates capillary formation at the endothelial cell-tumor cell interface P. G. Phillips, L. M. Birnby, A. Narendran, and W. L. Milonovich L278 No. 2. AUGUST 2001 INVITED REVIEW DNA damage and cell cycle checkpoints in hyperoxic lung injury: braking to facilitate repair M. A. O'Reilly EDITORIAL FOCUS Lung disease in cystic fibrosis: is airway surface liquid composition abnormal? A. S. Verkman X-ray microanalysis of airway surface liquid collected in cystic fibrosis mice J.-M. Zahm, S. Baconnais, D. J. Davidson, S. Webb, J. Dorin, N. Bonnet G. Balossier, and E. Puchelle EDITORIAL FOCUS Hypoxic pulmonary vasoconstriction: a multifactorial response? N. Weissmann, F. Grimminger, A. Olschewski, and W. Seeger o 5 Hypoxic release of calcium from the sarcoplasmic reticulum of pulmonary artery smooth muscle M. Dipp, P. C. G. Nye, and A. M. Evans EDITORIAL FOCUS Fas and apoptosis in the alveolar epithelium: holes in the dike? B. D. Uhal Recombinant human Fas ligand induces alveolar epithelial cell apoptosis and lung injury in rabbits G. Matute-Bello, W. C. Liles, C. W. Frevert, M. Nakamura, K. Ballman, C. Vathanaprida, P. A. Kiener, and T. R. Martin Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats R. L. Auten, Jr., S. N. Mason, D. T. Tanaka, K. Welty-Wolf, and M. H. Whorton Endocytosed SP-A and surfactant lipids are sorted to different organelles in rat type II pneumocytes H. Wissel, A. Lehfeldt, P. Klein, T. Miiller, and P. A. Stevens C-type natriuretic peptide system in fetal ovine pulmonary vasculature S. Lakshminrusimha, C. A. D’Angelis, J. A. Russell, L. C. Nielsen, S. F. Gugino, P. A. Nickerson, and R. H. Steinhorn Upregulation of lung soluble guanylate cyclase during chronic hypoxia is prevented by deletion of eNOS D. Li, V. E. Laubach, and R. A. Johns Chronic ethanol ingestion potentiates TNF-a-mediated oxidative stress and apoptosis in rat type II cells L. A. S. Brown, F. L. Harris, and D. M. Guidot Augmented metalloproteinase activity and acute lung injury in copper-deficient rats A. B. Lentsch, A. Kato, J. T. Saari, and D. A. Schuschke Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung K. Takeda, A. Haczku, J. J. Lee, C. G. Irvin, and E. W. Gelfand Cigarette smoke extract induces endothelin-1 via protein kinase C in pulmonary artery endothelial cells S.-D. Lee, D.-S. Lee, Y.-G. Chun, T.-S. Shim, C.-M. Lim, Y. Koh, W.-S. Kim, D.-S. Kim, and W.-D. Kim Human SLPI inactivation after cigarette smoke exposure in a new in vivo model of pulmonary oxidative stress E. Cavarra, M. Lucattelli, F. Gambelli, B. Bartalesi, S. Fineschi, A. Szarka, F. Giannerini, P. A. Martorana, and G. Lungarella Interactions between CBP, NF-«B, and CREB in the lungs after hemorrhage and endotoxemia R. Shenkar, H.-K. Yum, J. Arcaroli, J. Kupfner, and E. Abraham Migration and gelatinases in cultured fetal, adult, and hyperoxic alveolar epithelial cells S. Buckley, B. Driscoll, W. Shi, K. Anderson, and D. Warburton Role of p38 MAP kinase in diperoxovanadate-induced phospholipase D activation in endothelial cells V. Natarajan, W. M. Scribner, A. J. Morris, S. Roy, S. Vepa, J. Yang, R. Wadgaonkar, S. P. M. Reddy, J. G. N. Garcia, and N. L. Parinandi Regulation of anion secretion by nitric oxide in human airway epithelial cells M. Duszyk Optical method for quantifying rates of mucus secretion from single submucosal glands N. S. Joo, J. V. Wu, M. E. Krouse, Y. Saenz, and J. J. Wine EP. receptors mediate airway relaxation to substance P, ATP, and PGE2 C. N. Fortner, R. M. Breyer, and R. J. Paul eNOS and prostanoid enzymes in lungs of newborn piglets with chronic aortopulmonary shunts C. D. Fike, M. R. Kaplowitz, and M. Bousamra II Activation of the EGF receptor signaling pathway in airway epithelial cells exposed to Utah Valley PM W. Wu, J. M. Samet, A. J. Ghio, and R. B. Devlin Shear stress regulation of endothelial NOS in fetal pulmonary arterial endothelial cells involves PKC S. Wedgwood, J. M. Bekker, and S. M. Black Gene suppression by tristetraprolin and release by the p38 pathway W. Zhu, M. A. Brauchle, F. Di Padova, H. Gram, L. New, K. Ono, J. S. Downey, and J. Han Cytotoxic effects of cigarette smoke extract on an alveolar type II cell-derived cell line Y. Hoshino, T. Mio, S. Nagai, H. Miki, I. Ito, and T. Izumi No. 3. SEPTEMBER 2001 EB2001 SYMPOSIUM REPORTS Lung surfactant and reactive oxygen-nitrogen species: antimicrobial activity and host-pathogen interactions J. M. Hickman-Davis, F. C. Fang, C. Nathan, V. L. Shepherd, D. R. Voelker, and J. R. Wright L517 Intermittent hypoxia: cell to system N. R. Prabhakar, R. D. Fields, T. Baker, and E. C. Fletcher L524 Endothelial cellular response to altered shear stress A. B. Fisher, S. Chien, A. I. Barakat, and R. M. Nerem L529 EDITORIAL FOCUS Prostaglandins and sepsis: still a fascinating topic despite almost 40 years of research M. P. Fink Selective inhibition of COX-2 improves early survival in murine endotoxemia but not in bacterial peritonitis R. C. Reddy, G. H. Chen, K. Tateda, W. C. Tsai, S. M. Phare, P. Mancuso, M. Peters-Golden, and T. J. Standiford EDITORIAL FOCUS Serine/threonine phosphatase 2B regulates protein kinase C-a activity and endothelial barrier function D. Mehta Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction H. Lum, J. L. Podolski, M. E. Gurnack, I. T. Schulz, F. Huang, and O. Holian Serine proteases increase oxidative stress in lung cells K. Aoshiba, K. Yasuda, S. Yasui, J. Tamaoki, and A. Nagai Microtubule disassembly increases endothelial cell barrier dysfunction: role of MLC phosphorylation A. D. Verin, A. Birukova, P. Wang, F. Liu, P. Becker, K. Birukov, and J. G. N. Garcia Chronic ethanol downregulates PKA activation and ciliary beating in bovine bronchial epithelial cells T. A. Wyatt and J. H. Sisson Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats K. Abdulmalek, F. Ashur, N. Ezer, F. Ye, S. Magder, and S. N. A. Hussain Alveolar fluid reabsorption is impaired by increased left atrial pressures in rats F. J. Saldias, Z. S. Azzam, K. M. Ridge, A. Yeldandi, D. H. Rutschman, D. Schraufnagel, and J. I. Sznajder Adenoviral E1A primes alveolar epithelial cells to PMio-induced transcription of interleukin-8 P. S. Gilmour, I. Rahman, S. Hayashi, J. C. Hogg, K. Donaldson, and W. MacNee Nickel requires hypoxia-inducible factor-la, not redox signaling, to induce plasminogen activator inhibitor-1 A. S. Andrew, L. R. Klei, and A. Barchowsky AP-1-dependent induction of plasminogen activator inhibitor-1 by nickel does not require reactive oxygen A. S. Andrew, L. R. Klei, and A. Barchowsky Norepinephrine induces alveolar epithelial apoptosis mediated by a-, B-, and angiotensin receptor activation H. E. Dincer, N. Gangopadhyay, R. Wang, and B. D. Uhal Calcium sensitization produced by G protein activation in airway smooth muscle H. Yoshimura, K. A. Jones, W. J. Perkins, T. Kai, and D. O. Warner Mechanism of substance P-induced liquid secretion across bronchial epithelium L. Trout, M. R. Corboz, and S. T. Ballard H2Oz2 signals 5-HT-induced ERK MAP kinase activation and mitogenesis of smooth muscle cells S. L. Lee, A. R. Simon, W. W. Wang, and B. L. Fanburg Intrinsic AHR in IL-5 transgenic mice is dependent on CD4* cells and CD49d-mediated signaling M. T. Borchers, J. Crosby, P. Justice, S. Farmer, E. Hines, J. J. Lee, and N. A. Lee Surfactant proteins A and D in Eustachian tube epithelium R. Paananen, R. Sormunen, V. Glumoff, M. van Eijk, and M. Hallman Airway inflammation in nonasthmatic amateur runners M. R. Bonsignore, G. Morici, L. Riccobono, G. Insalaco, A. Bonanno, M. Profita, A. Paterno, C. Vassalle, A. Mirabella, and A. M. Vignola A low level of TNF-a mediates hemorrhage-induced acute lung injury via p55 TNF receptor Y. Song, L. Ao, C. D. Raeburn, C. M. Calkins, E. Abraham, A. H. Harken, and X. Meng Respiratory distress after intratracheal bleomycin: selective deficiency of surfactant proteins B and C R. C. Savani, R. I. Godinez, M. H. Godinez, E. Wentz, A. Zaman, Z. Cui, P. M. Pooler, S. H. Guttentag, M. F. Beers, L. W. Gonzales, and P. L. Ballard SP-D and GM-CSF regulate surfactant homeostasis via distinct mechanisms M. Ikegami, W. M. Hull, M. Yoshida, S. E. Wert, and J. A. Whitsett Persistent mucin glycoprotein alterations in equine recurrent airway obstruction A. M. Jefcoat, J. A. Hotchkiss, V. Gerber, J. R. Harkema, C. B. Basbaum, and N. E. Robinson Expression of CFTR and Cl” conductances in cells of pulmonary neuroepithelial bodies H. Yeger, J. Pan, X. W. Fu, C. Bear, and E. Cutz Lack of amiloride-sensitive transport across alveolar and respiratory epithelium of iNOS(—/—) mice in vivo K. M. Hardiman, J. R. Lindsey, and S. Matalon Inhibition of neutrophil apoptosis by acrolein: a mechanism of tobacco-related lung disease? E. I. Finkelstein, M. Nardini, and A. van der Vliet G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease B. J. McMorran, J. S. Palmer, D. P. Lunn, D. Oceandy, E. O. Costelloe, G. R. Thomas, D. A. Hume, and B. J. Wainwright No. 4. OCTOBER 2001 INVITED REVIEW Regulation of apoptosis by vasoactive peptides G. S. Filippatos, N. Gangopadhyay, O. Lalude, N. Parameswaran, S. I. Said, W. Spielman, and B. D. Uhal L749 EDITORIAL FOCUS Cell-, age-, and phenotype-dependent differences in the control of gene expression K. R. Stenmark Functional components of basic fibroblast growth factor signaling that inhibit lung elastin gene expression I. Carreras, C. B. Rich, J. A. Jaworski, S. J. Dicamillo, M. P. Panchenko, R. Goldstein, and J. A. Foster Interaction of bacterial lipopolysaccharide with mouse surfactant protein C inserted into lipid vesicles L. Augusto, K. Le Blay, G. Auger, D. Blanot, and R. Chaby PDGF-BB-mediated activation of p42““"* is independent of PDGF -receptor tyrosine phosphorylation N. J. Cartel, J. Liu, J. Wang, and M. Post Timing of hyperoxic exposure during alveolarization influences damage mediated by leukotrienes J. S. Manji, C. J. O'Kelly, W. I. Leung, and D. M. Olson L799 Oxidative interactions of synthetic lung epithelial lining fluid with metal-containing particulate matter G. Sun, K. Crissman, J. Norwood, J. Richards, R. Slade, and G. E. Hatch Signal transduction pathways of IL-18-mediated iNOS in pulmonary vascular smooth muscle cells J. D. Finder, J. L. Petrus, A. Hamilton, R. T. Villavicencio, B. R. Pitt, and S. M. Sebti Inhibition of geranylgeranylation blocks agonist-induced actin reorganization in human airway smooth muscle cells R. E. Lesh, C. W. Emala, H. T. Lee, D. Zhu, R. A. Panettieri, and C. A. Hirshman Human airway smooth muscle expresses 7 isoforms of adenylyl cyclase: a dominant role for isoform V D. Xu, C. Isaacs, I. P. Hall, and C. W. Emala Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA» A. Sano, X. Zhu, H. Sano, N. M. Mufioz, E. Boetticher, and A. R. Leff Identification of a region of strong discrimination in the pore of CFTR N. A. McCarty and Z.-R. Zhang Synergistic neutrophil elastase-cytokine interaction degrades collagen in three-dimensional culture Y. K. Zhu, X. D. Liu, C. M. Skéld, T. Umino, H. J. Wang, J. R. Spurzem, T. Kohyama, R. F. Ertl, and S. I. Rennard Redox regulation of endothelial barrier integrity X. Zhao, J. S. Alexander, S. Zhang, Y. Zhu, N. J. Sieber, T. Y. Aw, and D. L. Carden Augmented K* currents and mitochondrial membrane depolarization in pulmonary artery myocyte apoptosis S. Krick, O. Platoshyn, McDaniel, L. J. Rubin, and J. X.-J. Yuan Targeted transgenic expression of B2-adrenergic receptors to type II cells increases alveolar fluid clearance D. W. McGraw, N. Fukuda, P. F. James, S. L. Forbes, A. L. Woo, J. B. Lingrel, D. P. Witte, M. A. Matthay, and S. B. LigEgEe tt Proteins and lipids define the diffusional field of nitric oxide D. M. Porterfield, J. D. Laskin, S.-K. Jung, R. P. Malchow, B. Billack, P. J. S. Smith, and D. E. Heck Neutrophil maturation and activation determine anatomic site of clearance from circulation B. T. Suratt, S. K. Young, J. Lieber, J. A. Nick, P. M. Henson, and G. S. Worthen Effects of oxidant stress on inflammation and survival of iNOS knockout mice after marrow transplantation S. Yang, V. A. Porter, D. N. Cornfield, C. Milia, A. Panoskaltsis-Mortari, B. R. Blazar, and I. Y. Haddad Neuroepithelial bodies in mammalian lung express functional serotonin type 3 receptor X. W. Fu, D. Wang, J. Pan, S. M. Farragher, V. Wong, and E. Cutz L931 Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak T. C. Carpenter and K. R. Stenmark L941 Inhaled carbon monoxide and hyperoxic lung injury in rats C. E. Clayton, M. S. Carraway, H. B. Suliman, E. D. Thalmann, K. N. Thalmann, D. E. Schmechel, and C. A. Piantadosi Synergistic effects of tumor necrosis factor-a and thrombin in increasing endothelial permeability C. Tiruppathi, T. Naqvi, R. Sandoval, D. Mehta, and A. B. Malik Oxygen dependency of monoamine oxidase activity in the intact lung S. H. Audi, C. A. Dawson, S. B. Ahlf, and D. L. Roerig Role of cell surface glycosylation in mediating repair of human airway epithelial cell monolayers D. R. Dorscheid, K. R. Wojcik, K. Yule, and S. R. White L982 An immediate endothelial cell signaling response to lung ischemia C. Song, A. B. Al-Mehdi, and A. B. Fisher L993 VEGF induces airway epithelial cell proliferation in human fetal lung in vitro K. R. S. Brown, K. M. England, K. L. Goss, J. M. Snyder, and M. J. Acarregui Reduced endothelial nitric oxide synthase in lungs of chronically ventilated preterm lambs A. N. MacRitchie, K. H. Albertine, J. Sun, P. S. Lei, S. C. Jensen, A. A. Freestone, P. M. Clair, M. J. Dahl, E. A. Godfrey, D. P. Carlton, and R. D. Bland SPECIAL COMMUNICATIONS Limitations to oxygen diffusion and equilibration in in vitro cell exposure systems in hyperoxia and hypoxia C. B. Allen, B. K. Schneider, and C. W. White L1021 Ion transport by sheep distal airways in a miniature chamber F. J. Al-Bazzaz and C. Gailey L1028 No. 5. NOVEMBER 2001 EDITORIAL Ethics, revisited D. J. Benos INVITED REVIEW Transcriptional mechanisms of acute lung injury J. Fan, R. D. Ye, and A. B. Malik sGC and PDE5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension S. M. Black, L. S. Sanchez, E. Mata-Greenwood, J. M. Bekker, R. H. Steinhorn, and J. R. Fineman ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species S. Wedgwood, R. W. Dettman, and S. M. Black L1058 Keratinocyte growth factor reduces alveolar epithelial susceptibility to in vitro mechanical deformation J. Oswari, M. A. Matthay, and S. S. Margulies L1068 Changes in proteoglycans and lung tissue mechanics during excessive mechanical ventilation in rats R. Al-Jamal and M. S. Ludwig Dose-dependent lung remodeling in transgenic mice expressing transforming growth factor-a W. D. Hardie, A. Piljan-Gentle, M. R. Dunlavy, M. Ikegami, and T. R. Korfhagen Apoptosis by pan-caspase inhibitors in lipopolysaccharide-activated macrophages S. O. Kim, K. Ono, and J. Han L1095 Genes other than TLR4 are involved in the response to inhaled LPS E. Lorenz, M. Jones, C. Wohlford-Lenane, N. Meyer, K. L. Frees, N. C. Arbour, and D. A. Schwartz Inhibition of voltage-gated K* currents by endothelin-1 in human pulmonary arterial myocytes L. A. Shimoda, J. T. Sylvester, G. M. Booth, T. H. Shimoda, S. Meeker, B. J. Undem, and J. S. K. Sham Chlorzoxazone or 1-EBIO increases Na* absorption across cystic fibrosis airway epithelial cells L. Gao, J. R. Yankaskas, C. M. Fuller, E. J. Sorscher, S. Matalon, H. J. Forman, and C. J. Venglarik Autocrine signaling by IL-10 mediates altered responsiveness of atopic sensitized airway smooth muscle M. M. Grunstein, H. Hakonarson, J. Leiter, M. Chen, R. Whelan, J. S. Grunstein, and S. Chuang Upregulation of transcription factors in lung in the early phase of postpneumonectomy lung growth L. J. Landesberg, R. Ramalingam, K. Lee, T. K. Rosengart, and R. G. Crystal Hyperoxia increases leptin production: a mechanism mediated through endogenous elevation of corticosterone C. Barazzone-Argiroffo, P. Muzzin, Y. R. Donati, C.-D. Kan, M. L. Aubert, and P.-F. Piguet L1150 NO and prostaglandin interactions during hemodynamic stress in the fetal ovine pulmonary circulation J. P. Zenge, R. L. Rairigh, T. R. Grover, L. Storme, T. A. Parker, J. P. Kinsella, and S. H. Abman Partial correction of defective Cl” secretion in cystic fibrosis epithelial cells by an analog of squalamine C. Jiang, E. R. Lee, M. B. Lane, Y.-F. Xiao, D. J. Harris, and S. H. Cheng Examining basal chloride transport using the nasal potential difference response in a murine model K. G. Brady, T. J. Kelley, and M. L. Drumm Induction of c-jun and TGF-81 in Fischer 344 rats during amiodarone-induced pulmonary fibrosis W. H. Chung, B. M. Bennett, W. J. Racz, J. F. Brien, and T. E. Massey L1180 Amiodarone inhibits lung degradation of SP-A and perturbs the distribution of lysosomal enzymes A. Baritussio, S. Marzini, M. Agostini, A. Alberti, C. Cimenti, D. Bruttomesso, E. Manzato, D. Quaglino, and A. Pettenazzo L1189 Genetic variability in the development of pulmonary tolerance to inhaled pollutants in inbred mice S. C. Wesselkamper, L. C. Chen, S. R. Kleeberger, and T. Gordon L1200 Impaired functional activity of alveolar macrophages from GM-CSF-deficient mice R. Paine Ill, S. B. Morris, H. Jin, S. E. Wilcoxen, S. M. Phare, B. B. Moore, M. J. Coffey, and G. B. Toews [ranslational activation and repression by distinct elements within the 5'-UTR of ENaC a-subunit mRNA G. Otulakowski, T. Freywald, Y. Wen, and H. O’Brodovich Cytokine treatment increases arginine metabolism and uptake in bovine pulmonary arterial endothelial cells L. D. Nelin, H. E. Nash, and L. G. Chicoine Direct and indirect bacterial killing functions of neutrophil defensins in lung explants G. A. Porro, J.-H. Lee, J. de Azavedo, I. Crandall, T. Whitehead, E. Tullis, T. Ganz, M. Liu, A. S. Slutsky, and H. Zhang L1240 Lung fibroblasts inhibit activation-induced death of T cells through PGE2-dependent mechanisms T. O. Yarovinsky and G. W. Hunninghake L1248 Prostaglandin Ez inhibits fibroblast chemotaxis T. Kohyama, R. F. Ertl, V. Valenti, J. Spurzem, M. Kawamoto, Y. Nakamura, T. Veys, L. Allegra, D. Romberger, and S. I. Rennard Decreased surfactant proteins in lambs with pulmonary hypertension secondary to increased blood flow J. A. Gutierrez, A. J. Parry, D. M. McMullan, C. J. Chapin, and J. R. Fineman Nuclear factor-«B augments B2-adrenergic receptor expression in human airway epithelial cells M. O. Aksoy, W. Bin, Y. Yang, D. Yun-You, and S. G. Kelsen Preventing mediastinal shift after pneumonectomy impairs regenerative alveolar tissue growth C. C. W. Hsia, E. Y. Wu, E. Wagner, and E. R. Weibel IL-4 differentially regulates eotaxin and MCP-4 in lung epithelium and circulating mononuclear cells H. Nakamura, A. D. Luster, H. Tateno, S. Jedrzkiewicz, G. Tamura, K. J. Haley, E. A. Garcia-Zepeda, K. Yamaguchi, and C. M. Lilly L1288 CCSP modulates airway dysfunction and host responses in an Ova-challenged mouse model S.-Z. Wang, C. L. Rosenberger, T. M. Espindola, E. G. Barrett, Y. Tesfaigzi, D. E. Bice, and K. S. Harrod L1303 No. 6. DECEMBER 2001 INVITED REVIEW Human mast cell and airway smooth muscle cell interactions: implications for asthma S. Page, A. J. Ammit, J. L. Black, and C. L. Armour EDITORIAL FOCUS Pulmonary edema fluid movement within the lung H. O’Brodovich L1324 Rapid alveolar liquid removal by a novel convective mechanism P. M. Wang, Y. Ashino, H. Ichimura, and J. Bhattacharya Li1327 EDITORIAL FOCUS Lysophospholipids in the regulation of endothelial barrier function H. Lum L1335 Platelet lipid(s) bound to albumin increases endothelial electrical resistance: mimicked by LPA F. L. Minnear, S. Patil, D. Bell, J. P. Gainor, and C. A. Morton L1i337 EDITORIAL FOCUS Oxygen-sensitive K* channel(s): where and what? J, X.-J. Yuan L1345 Differential expression of Ky channel a- and B-subunits in the bovine pulmonary arterial circulation E. A. Coppock and M. M. Tamkun L1350