Alzheimer's Disease Cellular and Molecular Aspects of Amyloid p Subcellular Biochemistry Volume 38 SUBCELLULAR BIOCHEMISTRY SERIES EDITOR J. ROBIN HARRIS, Institute of Zoology, University of Mainz, Mainz, Germany ASSISTANT EDITOR B. B, BISWAS, University of Calcutta, Calcutta, India Recent Volumes in This Series Volume 28 Cholesterol: Its Functions and Metabolism in Biology and Medicine Edited by Robert Bittman Volume 29 Plant-Microbe Interactions Edited by B. B. Biswas and H. K. Das Volume 30 Fat-Soluble Vitamins Edited by Peter I. Quinn and Valerian E, Kagan Volume 31 Intermediate Filaments Edited by Harald Herrmann and I. Robin Harris Volume 32 a-Gal and Anti-Gal: al,3-Galactosyltransferase, a-Gal Epitopes, and the Natural Anti-Gal Antibody Edited by Uri Galili and lose Luis Avila Volume 33 Bacterial Invasion into Eukaryotic Cells Edited by Tobias A. Oelschlaeger and lorg Hacker Volume 34 Fusion of Biological Membranes and Related Problems Edited by Herwig Hilderson and Stephen Fuller Volume 35 Enzyme-Catalyzed Electron and Radical Transfer Edited by Andreas Holzenburg and Nigel S. Scrutton Volume 36 Phospholipid Metabolism in Apoptosis Edited by Peter I. Quinn and Valerian E. Kagan Volume 37 Membrane Dynamics and Domains Edited by Peter I. Quinn Volume 38 Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid p Edited by I. Robin Harris and Falk Fahrenholz A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher Alzheimer's Disease Cellular and Molecular Aspects of Amyloid |3 Subcellular Biochemistry Volume 38 Edited by J. Robin Harris Institute of Zoology University of Mainz Mainz, Germany and Falk Fahrenholz Institute of Biochemistry University of Mainz Mainz, Germany ^ S p ri inger This series is a continuation of the journal Sub-Cellular Biochemistry, Volumes 1 to 4 of which were published quarterly from 1972 to 1975 ISSN 0306-0225 ISBN 0-387-23225-7 elSBN 0-387-23226-5 ©2005 Springer Science-fBusiness Media, Inc. All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science-I-Business Media, Inc., 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed in the United States of America. (BS/DH) 9 8 7 6 5 4 3 21 springeronline.com INTERNATIONAL ADVISORY EDITORIAL BOARD R BITTMAN, City University of New York, New York, USA D DASGUPTA, Saha Institute of Nuclear Physics, Calcutta, India H ENGELHARDT, Max-Planck-Institute for Biochemistry, Martinsried, Germany A-H ETEMADI, University of Paris VI, Paris, France S FULLER, University of Oxford, Oxford, UK J HACKER, University of Wurzburg, Wiirzburg, Germany H HERRMANN, German Cancer Research Center, Heidelberg, Germany A HOLZENBURG, Texas A&M University, College Station, Texas, USA. J B LLOYD, University of Sunderland, Sunderland, England, UK P QUINN, King's College London, London, England, UK S ROTTEM, The Hebrew University, Jerusalem, Israel Contributors Christian Behl, Institute for Physiological Chemistry & Pathobiochemistry, Faculty of Medicine, Johannes Gutenberg- University Mainz, Duesbergweg 6, D-55099 Mainz, Germany Peter Borghgraef, Experimental Genetics Group, Department of Human Genetics, K.U.Leuven, B-3000 Leuven, Belgium Ayelen Bulloj, Institute de Quimica y Fisicoquimica Biologicas (IQUIFIB), CONICET, Catedra de Quimica Biologica Patologica, Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, C113AAD, Buenos Aires, Argentina Ashley I. Bush, Harvard Medical School and Massachusetts General Hospital, Boston MA 02114, USA Miguel Calero, Centro Nacional de Microbiologia, Institute de Salud Carlos III, 28220 Majadahonda, Madrid, Spain Mireia Coma, Unitat de Senyalitzacio Cel lular, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08003-Barcelona, Spain Donald B. Carter, CNS Therapeutics, Pfizer Corporation, Kalamazoo, MI, USA Vll 'iii Contribittors Eduardo M. Castano, Institute de Quimica y Fisicoquimica Biologicas (IQUIFIB), CONICET, Catedra de Quimica Biologica Patologica, Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, C113AAD, Buenos Aires, Argentina Marcela Colombres, FONDA-Biomedical Center, P. Catholic University of Chile, Santiago, Chile Math P. Cuajungco, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston MA 02114, USA Use Dewachter, Experimental Genetics Group, Department of Human Genetics, K.U.Leuven, B-3000 Leuven, Belgium Lisbell Estrada, Protein Misfolding Disorders Laboratory, Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA Gunter P. Eckert, Department of Pharmacology, ZAFES, Biocenter University of Frankfurt, Germany Christopher Exley, Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire, ST5 5BG, UK Falk Fahrenholz, Institute of Biochemistry, Johannes Gutenberg- University, Becherweg 30, Mainz D-55099, Germany Bias Frangione, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA Christopher, J. Frederickson, NeuroBioTex, Inc. and University of Texas Medical Branch, Galveston TX 77550 USA Jorge Ghiso, Department of Pathology, Room-TH432, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA Charles C. Glabe, University of California, Irvine, Irvine, CA 92697, USA J. Robin Harris, Institute of Zoology, University of Mainz, D-55099 Mainz, Germany Contributors i: Tobias Hartmann, Center for Molecular Biology Heidelberg (ZMBH), University of Heidelberg, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany Nibaldo C. Inestrosa, FONDA-Biomedical Center, P. Catholic University of Chile, Santiago 114-D, Chile Vernon M. Ingram, Department of Biology, M.I.T, 31 Ames Street, Cambridge, IvIA 02139,USA Hideyo Inouye, Department of Biology, Higgins Hall 510, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467-3811, USA Daniel A. Kirschner, Department of Biology, Boston College, Chestnut Hill, MA 02467-3811, USA Elzbieta Kojro, Institute of Biochemistry, Johannes Gutenberg- University, Becherweg 30, Mainz D-55099, Germany Maria Celeste Leal, Institute de Quimica y Fisicoquimica Biologicas (IQUIFIB), CONICET, Catedra de Quimica Biologica Patologica, Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, CI 13AAD, Buenos Aires, Argentina Nathaniel G. N. Milton, Department of Clinical Neurosciences, Royal Free & University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK Laura Morelli, Institute de Quimica y Fisicoquimica Biologicas (IQUIFIB), CONICET, Catedra de Quimica Biologica Patologica, Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, CI 13AAD, Buenos Aires, Argentina Werner E. Miiller, Department of Pharmacology, ZAFES, Biocenter University of Frankfurt, Frankfurt, Germany Francisco Jose Muiioz, Unitat de Senyalitzacio Cel lular, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Calle Dr Aiguader 80, 08003-Barcelona, Spain Contributors Agueda Rostagno, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA Juan Paulo Sagal, FONDA-Biomedical Center, P. Catholic University of Chile, Santiago, Chile Montserrat Sole, Unitat de Senyalitzacio Cel lular, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08003-Barcelona, Spain Claudio Soto, Protein Misfolding Disorders Laboratory, Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA Tom van Dooren, Experimental Genetics Group, Department of Human Genetics, K.U.Leuven, B-3000 Leuven, Belgium Fred van Leuven, Experimental Genetics Group, Department of Human Genetics, K.U.Leuven, Campus Gasthuisberg, O & N6, B-3G00 Leuven, Belgium Robert Vassar, Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Chicago, IL 60611, USA W.G. Wood, Department of Pharmacology, University of Minnesota School of Medicine, Minneapolis, USA Katsuhiko Yanagisawa, National Institute for Longevity Sciences, Gengo 36-3, Morioka, 474-8522 Obu, Japan