AA SS RR..PP .. LLAANN IIMMOONN HH 2@ . INTEGRATIVERX INSIGHTBB COM S ’ P A IMON S ROSPECT POTHECARY . . WWW INTEGRATIVERXPHARMACY COM (502) 228-4161 9217 US Highway 42 Prospect, KY 40059 N UTRITION AND C ANCER Obstacles and Enhancements to Health Alan Simon R.Ph. D IET IS IMPORTANT (cid:1) Harvard Center for Cancer Prevention (cid:1) “It’s been estimated that the combination of poor diet and obesity cause nearly a qquuaarrtteerr ooff aallll ccaanncceerrss wwoorrllddwwiiddee,, sseeccoonndd only to tobacco use. Add to this the fact that most dietary factors that help lower the risk of cancer also lower the risk of heart disease, stroke, and diabetes, and the importance of a healthy diet becomes even more pronounced.” AN UNHEALTHY DIET AFFECTS . CANCER OUTCOMES Journal of the American Medical (cid:1) August 15, 2007, Association, researchers show that patients with the highest intake of a Western-pattern diet, characterized by high intakes of red meat, sugar desserts, high fat, and refined grains, have a 3-fold increase in cancer recurrences and mortality. (cid:1) Patients were enrolled in a National Cancer Institute–sponsored rraannddoommiizzeedd aaddjjuuvvaanntt cchheemmootthheerraappyy ttrriiaall kknnoowwnn aass CCaanncceerr aanndd LLeeuukkeemmiiaa Group B (CALGB 89803). The trial compared therapy with weekly fluorouracil and leucovorin vs therapy with weekly irinotecan, fluorouracil, and leucovorin. (cid:1) "We identified 2 major dietary patterns, prudent and Western pattern. The prudent diet was characterized by high intake of fruits and vegetables, poultry, and fish. (cid:1) During a median follow-up of 5.3 years for the overall cohort, 324 patients had cancer recurrence. A total of 223 patients died after recurrence, and 28 died without documented recurrence. A higher intake of a Western- pattern diet after cancer diagnosis was associated with a significantly worse disease-free survival, including colon cancer recurrences or death. H L K T C EALTHY IFESTYLE EY O ANCER P REVENTION (cid:1) The President's Cancer Panel issues a report every year that focuses on one aspect of what is happening in the United States in terms of cancer. (cid:1) This year's effort "centers on lifestyle changes, and two issues that are actually quite different," said panel member Margaret L. Kripke, executive vice president and chief academic officer at the University of TTeexxaass MM.. DD.. AAnnddeerrssoonn CCaanncceerr CCeenntteerr,, iinn HHoouussttoonn.. (cid:1) One issue is nutrition, exercise and the fight against obesity , and the other is the battle to cut tobacco use, Kripke said. (cid:1) The experts call for a move toward a "culture of wellness" in the United States. This culture would embrace healthy living as a goal and promote a healthy lifestyle as a way of achieving wellness. living a healthy lifestyle lowers a (cid:1) In addition, person's risk of cancer recurrence and improves outcomes after cancer, Kripke said. (cid:1) Plant foods, fiber, and rectal cancer. (cid:1) Slattery ML, Curtin KP, Edwards SL, Schaffer DM. (cid:1) Health Research Center, University of Utah, Salt Lake City, and the Kaiser Permanente Medical Research Program, Oakland, CA, USA. [email protected] (cid:1) BACKGROUND: Associations between colon and rectal cancer and intakes of vegetables, other plant foods, and fiber have stimulated much debate. OBJECTIVE: We examined the association between rectal cancer and plant food and fiber intakes. DESIGN: Data from 952 incident cases of rectal cancer were compared with data from 1205 population-based controls living in Utah or enrolled in the Kaiser PPeerrmmaanneennttee MMeeddiiccaall CCaarree PPrrooggrraamm iinn nnoorrtthheerrnn CCaalliiffoorrnniiaa RREESSUULLTTSS:: RReeccttaall ccaanncceerr was inversely associated with intakes of vegetables (odds ratio: 0.72; 95% CI: 0.54, 0.98), fruit (0.73; 0.53, 0.99), and whole-grain products (0.69; 0.51, 0.94), whereas a high intake of refined-grain products was directly associated with an increased risk of rectal cancer (1.42; 1.04, 1.92). Similarly, relative to low fiber intakes, high intakes of dietary fiber reduced the risk of rectal cancer (0.54; 0.37, 0.78). The reduced risk of rectal cancer associated with vegetable (0.48; 0.29, 0.80), fruit (0.63; 0.38, 1.06), and fiber (0.40; 0.22, 0.71) intakes was strongest for persons who received the diagnosis A threshold effect at approximately 5 servings of after age 65 y. vegetables day was needed to see a reduced risk of rectal cancer. CONCLUSIONS: The results suggest that plant foods may be important in the etiology of rectal cancer in both men and women. Age at diagnosis appears to play an important role in the association. (cid:1) PMID: 14749234 [PubMed - indexed for MEDLINE] C R H W ANCER ISK IGHER ITH W D ESTERN IET (cid:1) Older Chinese Women Who Ate Diet Heavy on Red Meat and Sugar Had More Breast Cancer, Study Says (cid:1) July 12, 2007 (cid:1) A new study suggests the more Western your diet is — meaning heavy on meat, starch and sugar — the higher your risk for cancer may be. (cid:1) The study followed older Asian women who had been placed on two separate diets: traditional cuisine rich in vegetables and fish and a Westernized diet heavy on red meat and sugar. Women who adopted the Western diet had higher rates of breast cancer. D P IETARY ATTERNS AND P C R ROSTATE ANCER ISK (cid:1) Ann Epidemiol. 2008 Feb 7 (cid:1) Dietary Patterns Identified Using Factor Analysis and Prostate Cancer Risk: A Case Control Study in Western Australia. (cid:1) AmbrosiniGL, Fritschi L, De Klerk NH, Mackerras D, Leavy J. (cid:1) From the School of Population Health, University of Western Australia (G.L.A., J.L.); Western Australian Institute for Medical Research (L.F.), Telethon Institute for Child Health Research, Western Australia (N.H.D.K.); and MenziesSchool of Health Research and Institute of Advanced Studies, Charles Darwin University, Northern Territory (D.M.), Australia. (cid:1) PURPOSE: Dietary patterns offer an alternative method for analyzing dietary intakes that take into account the whole diet. We investigated empirical dietary patterns and prostate cancer risk in Western Australia (WA) using a population-based case-control study. METHODS: Incident prostate cancer cases wweerree iiddeennttiiffiieedd vviiaa tthhee WWAA CCaanncceerr RReeggiissttrryy.. CCoonnttrroollss wweerree ssoouurrcceedd ffrroomm tthhee WWAA eelleeccttoorraall rroollll,, ffrreeqquueennccyy matched on age. A food frequency questionnaire (FFQ) estimated usual dietary intake from 10 years earlier. Factor analysis identified dietary patterns in FFQ data. Effects of independent dietary patterns on prostate cancer risk were examined using unconditional logistic regression, adjusting for potential confounders. : A total of 546 cases and 447 controls provided data. RESULTS Three An distinct dietary patterns were identified, which we labeled vegetable, Western, and health-conscious. increased risk for prostate cancer was observed with the Western pattern, which consisted of high intakes of red and processed meats, fried fish, hamburgers, chips, high-fat milk, and white bread. Men in the highest quartile for Western pattern score had an odds ratio of 1.82 (95% confidence interval 1.15-2.87, trend p = 0.02). Results were similar for aggressive cases and attenuated for non- CONCLUSIONS: A western style diet may lead aggressive cancers. to increased risks for prostate cancer, especially aggressive prostate cancer. (cid:1) PMID: 18261927 [PubMed-as supplied by publisher] J N C OURNAL OF THE ATIONAL ANCER I NSTITUTE (cid:1) The odds are about 50:50 that a breast cancer survivor over 60 will die as a result of something else – most likely heart disease or osteoporosis – according to a new report in the Journal of the National Cancer Institute. It calls for greater attention to these women's other medical problems. (cid:1) JOURNAL OF THE NATIONAL CANCER INSTITUTE Vol. 100 Issue 4 Feb 2008 ISSN:1460-2105 (cid:1) Competing causes of death from a randomized trial of extended adjuvant endocrine therapy for breast cancer. (cid:1)(cid:1) AAbbssttrraacctt::BBAACCKKGGRROOUUNNDD:: OOllddeerr wwoommeenn wwiitthh eeaarrllyy--ssttaaggee bbrreeaasstt ccaanncceerr eexxppeerriieennccee hhiigghheerr rraatteess ooff nnoonn-- breast cancer-related death. We examined factors associated with cause-specific death in a large cohort of breast cancer patients treated with extended adjuvant endocrine therapy. METHODS: In the MA.17 trial, conducted by the National Cancer Institute of Canada Clinical Trials Group, 5170 breast cancer patients (median age = 62 years; range = 32-94 years) who were disease free after approximately 5 years of adjuvant tamoxifentreatment were randomly assigned to treatment with letrozole(2583 women) or placebo (2587 women). The median follow-up was 3.9 years (range 0-7 years). We investigated the association of 11 baseline factors with the competing risks of death from breast cancer, other malignancies, and other causes. All statistical tests were two-sided likelihood ratio criterion tests. RESULTS: During follow-up, 256 deaths were reported (102 from breast cancer, 50 from other malignancies, 100 from other causes, and four from an unknown cause). Non-breast cancer deaths accounted for 60% of the 252 known deaths (72% for those > or = 70 years and 48% for those < 70 years). Two baseline factors were differentially associated with type of death: cardiovascular disease was associated with a statistically significant increased risk of death from other causes (P.002), and osteoporosis was associated with a statistically significant increased risk of death from other malignancies (P.05). An increased risk of breast cancer-specific death was associated with lymph node involvement (P < .001). Increased risk of death from all three causes was associated with older age (P < .001). CONCLUSIONS: Non-breast cancer-related deaths were more common than breast cancer-specific deaths in this cohort of 5-year breast cancer survivors, especially among older women.} (cid:1) Authors: Chapman, Judith-Anne W, MengDaniel, Shepherd Lois, ParulekarWendy, Ingle, James N Muss, Hyman B, Palmer, Michael, Yu, Changhong, Goss, Paul E (cid:1) Affiliation:National Cancer Institute of Canada Clinical Trials Group, Queen's University, 10 Stuart St, Kingston, ON, Canada. [email protected] (cid:1) Abstract from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine N UTRITION (cid:1) The taking in and use of food and other nourishing material by the body. (cid:1) A 3-part process. (cid:1) First, food or drink is consumed. (cid:1) Second, the body breaks down the food or drink into nutrients. (cid:1)(cid:1) TThhiirrdd,, tthhee nnuuttrriieennttss ttrraavveell tthhrroouugghh tthhee bbllooooddssttrreeaamm ttoo ddiiffffeerreenntt ppaarrttss of the body where they are used as "fuel" and for many other purposes. (cid:1) To give the body proper nutrition, a person has to eat and drink enough of the foods that contain key nutrients (vitamins, minerals, protein, carbohydrates, fat, and water). (cid:1) National Cancer Institute