Acupuncture Needles being inserted into a person's skin Alternative therapy Benefits Placebo MeSH D015670 ICD-10- PCS [1] (http://www.icd10data.com/ICD10PCS/Codes/) ICD-9 99.91 (http://icd9cm.chrisendres.com/index.php? srchtype=procs&srchtext=99.91&Submit=Search&action=search) -99.92 (http://icd9cm.chrisendres.com/index.php? srchtype=procs&srchtext=99.92&Submit=Search&action=search) OPS- 301 code 8-975 (http://ops.icd-code.de/ops/code/8-975.html).2 Acupuncture From Wikipedia, the free encyclopedia Acupuncture[note 1] is a form of alternative medicine[2] in which thin needles are inserted into the body.[3] It is a key component of traditional Chinese medicine (TCM).[4] TCM theory and practice are not based upon scientific knowledge,[5] and acupuncture is a pseudoscience. [6][7] There is a diverse range of acupuncture theories based on different philosophies,[8] and techniques vary depending on the country.[9] The method used in TCM is likely the most widespread in the US.[2] It is most often used for pain relief, [10][11] though it is also used for a wide range of other conditions.[4] Acupuncture is generally used only in combination with other forms of treatment.[12] The conclusions of many trials and numerous systematic reviews of acupuncture are largely inconsistent.[10][13] An overview of Cochrane reviews found that acupuncture is not effective for a wide range of conditions, and it suggests acupuncture may be effective only for chemotherapy-induced nausea/vomiting, postoperative nausea/vomiting, and idiopathic headache.[13] An overview of high- quality Cochrane reviews suggests that acupuncture may alleviate certain kinds of pain.[14] A systematic review of systematic reviews found little evidence of acupuncture's effectiveness in treating pain.[10] The evidence suggests that short-term treatment with acupuncture does not produce long-term benefits.[15] Some research results suggest acupuncture can alleviate pain, though the majority of research suggests Page 1 of 44 Acupuncture - Wikipedia 12/28/2016 https://en.wikipedia.org/wiki/Acupuncture that acupuncture's effects are mainly due to placebo.[9] A systematic review concluded that the analgesic effect of acupuncture seemed to lack clinical relevance and could not be clearly distinguished from bias. [16] Acupuncture is generally safe when done by an appropriately trained practitioner using clean needle technique and single-use needles.[17][18] When properly delivered, it has a low rate of mostly minor adverse effects.[3][17] Accidents and infections are associated with infractions of sterile technique or neglect of the practitioner.[18] A review stated that the reports of infection transmission increased significantly in the prior decade.[19] The most frequently reported adverse events were pneumothorax and infections.[10] Since serious adverse events continue to be reported, it is recommended that acupuncturists be trained sufficiently to reduce the risk.[10] A meta-analysis found that acupuncture for chronic low back pain was cost-effective as an adjunct to standard care,[20] while a systematic review found insufficient evidence for the cost-effectiveness of acupuncture in the treatment of chronic low back pain.[21] Scientific investigation has not found any histological or physiological evidence for traditional Chinese concepts such as qi, meridians, and acupuncture points,[n 1][25] and many modern practitioners no longer support the existence of life force energy (qi) flowing through meridians, which was a major part of early belief systems.[8][26][27] Acupuncture is believed to have originated around 100 BC in China, around the time The Yellow Emperor's Classic of Internal Medicine (Huangdi Neijing) was published,[28] though some experts suggest it could have been practiced earlier.[9] Over time, conflicting claims and belief systems emerged about the effect of lunar, celestial and earthly cycles, yin and yang energies, and a body's "rhythm" on the effectiveness of treatment.[29] Acupuncture grew and diminished in popularity in China repeatedly, depending on the country's political leadership and the favor of rationalism or Western medicine.[28] Acupuncture spread first to Korea in the 6th century AD, then to Japan through medical missionaries,[30] and then to Europe, starting with France.[28] In the 20th century, as it spread to the United States and Western countries, the spiritual elements of acupuncture that conflict with Western beliefs were abandoned in favor of tapping needles into nerves.[28][31][32] Contents ◾ 1 Clinical practice ◾ 1.1 Needles ◾ 1.2 Needling technique ◾ 1.3 Related practices ◾ 2 Effectiveness ◾ 2.1 Sham acupuncture and research ◾ 2.2 Publication bias ◾ 2.3 Specific conditions ◾ 2.4 Moxibustion and cupping Page 2 of 44 Acupuncture - Wikipedia 12/28/2016 https://en.wikipedia.org/wiki/Acupuncture One type of acupuncture needle ◾ 3 Safety ◾ 3.1 Adverse events ◾ 3.2 Cost-effectiveness ◾ 3.3 Risk of forgoing conventional medical care ◾ 4 Conceptual basis ◾ 4.1 Traditional ◾ 4.2 Purported scientific basis ◾ 5 History ◾ 5.1 Origins ◾ 5.2 Early development in China ◾ 5.3 International expansion ◾ 6 Adoption ◾ 7 Regulation ◾ 8 See also ◾ 9 Bibliography ◾ 10 Notes ◾ 11 References ◾ 12 Further reading ◾ 13 External links Clinical practice Acupuncture is a form of alternative medicine.[2] It is commonly used for pain relief,[10][11] though it is also used to treat a wide range of conditions.[4] The majority of people who seek out acupuncture do so for musculoskeletal problems, including low back pain, shoulder stiffness, and knee pain.[33] Acupuncture is generally only used in combination with other forms of treatment.[12] For example, American Society of Anesthesiologists states it may be considered in the treatment for nonspecific, noninflammatory low back pain only in conjunction with conventional therapy.[34] Acupuncture is the insertion in the skin of thin needles.[3] According to the Mayo Foundation for Medical Education and Research (Mayo Clinic), a typical session entails lying still while approximately five to twenty needles are inserted; for the majority of cases, the needles will be left in place for ten to twenty minutes.[35] It can be associated with the application of heat, pressure, or laser light.[3] Classically, acupuncture is individualized and based on philosophy and intuition, and not on scientific research.[36] There is also a non-invasive therapy developed in early 20th century Japan using an elaborate set of "needles" for the treatment of children (shōnishin or shōnihari).[37][38] Page 3 of 44 Acupuncture - Wikipedia 12/28/2016 https://en.wikipedia.org/wiki/Acupuncture Acupuncture needles Clinical practice varies depending on the country.[9][39] A comparison of the average number of patients treated per hour found significant differences between China (10) and the United States (1.2).[40] Chinese herbs are often used.[41] There is a diverse range of acupuncture approaches, involving different philosophies.[8] Although various different techniques of acupuncture practice have emerged, the method used in traditional Chinese medicine (TCM) seems to be the most widely adopted in the US.[2] Traditional acupuncture involves needle insertion, moxibustion, and cupping therapy,[17] and may be accompanied by other procedures such as feeling the pulse and other parts of the body and examining the tongue.[2] Traditional acupuncture involves the belief that a "life force" (qi) circulates within the body in lines called meridians.[42] The main methods practiced in the UK are TCM and Western medical acupuncture.[43] The term Western medical acupuncture is used to indicate an adaptation of TCM-based acupuncture which focuses less on TCM.[42][44] The Western medical acupuncture approach involves using acupuncture after a medical diagnosis.[42] Limited research has compared the contrasting acupuncture systems used in various countries for determining different acupuncture points and thus there is no defined standard for acupuncture points.[45] In traditional acupuncture, the acupuncturist decides which points to treat by observing and questioning the patient to make a diagnosis according to the tradition used. In TCM, the four diagnostic methods are: inspection, auscultation and olfaction, inquiring, and palpation. Inspection focuses on the face and particularly on the tongue, including analysis of the tongue size, shape, tension, color and coating, and the absence or presence of teeth marks around the edge.[46] Auscultation and olfaction involves listening for particular sounds such as wheezing, and observing body odor.[46] Inquiring involves focusing on the "seven inquiries": chills and fever; perspiration; appetite, thirst and taste; defecation and urination; pain; sleep; and menses and leukorrhea.[46] Palpation is focusing on feeling the body for tender "A-shi" points and feeling the pulse.[46] Needles The most common mechanism of stimulation of acupuncture points employs penetration of the skin by thin metal needles, which are manipulated manually or the needle may be further stimulated by electrical stimulation (electroacupuncture).[2] Acupuncture needles are typically made of stainless steel, making them flexible and preventing them from rusting or breaking.[47] Needles are usually disposed of after each use to prevent contamination.[47] Reusable needles when used should be sterilized between applications.[47][48] Needles vary in length between 13 to 130 millimetres (0.51 to 5.12 in), with shorter needles used near the face and eyes, and longer needles in areas with thicker tissues; needle diameters vary from 0.16 mm (0.006 in) to 0.46 mm (0.018 in),[49] with thicker needles used on Page 4 of 44 Acupuncture - Wikipedia 12/28/2016 https://en.wikipedia.org/wiki/Acupuncture Traditional and modern Japanese guiding tube needles more robust patients. Thinner needles may be flexible and require tubes for insertion. The tip of the needle should not be made too sharp to prevent breakage, although blunt needles cause more pain.[50] Apart from the usual filiform needle, other needle types include three-edged needles and the Nine Ancient Needles.[49] Japanese acupuncturists use extremely thin needles that are used superficially, sometimes without penetrating the skin, and surrounded by a guide tube (a 17th-century invention adopted in China and the West). Korean acupuncture uses copper needles and has a greater focus on the hand.[39] Needling technique Insertion The skin is sterilized and needles are inserted, frequently with a plastic guide tube. Needles may be manipulated in various ways, including spinning, flicking, or moving up and down relative to the skin. Since most pain is felt in the superficial layers of the skin, a quick insertion of the needle is recommended.[51] Often the needles are stimulated by hand in order to cause a dull, localized, aching sensation that is called de qi, as well as "needle grasp," a tugging feeling felt by the acupuncturist and generated by a mechanical interaction between the needle and skin.[2] Acupuncture can be painful.[52] The skill level of the acupuncturist may influence how painful the needle insertion is, and a sufficiently skilled practitioner may be able to insert the needles without causing any pain.[51] De-qi sensation De-qi (Chinese: 得气; pinyin: dé qì; "arrival of qi") refers to a sensation of numbness, distension, or electrical tingling at the needling site which might radiate along the corresponding meridian. If de-qi can not be generated, then inaccurate location of the acupoint, improper depth of needle insertion, inadequate manual manipulation, or a very weak constitution of the patient can be considered, all of which are thought to decrease the likelihood of successful treatment. If the de-qi sensation does not immediately occur upon needle insertion, various manual manipulation techniques can be applied to promote it (such as "plucking", "shaking" or "trembling").[53] Once de-qi is achieved, further techniques might be utilized which aim to "influence" the de-qi; for example, by certain manipulation the de-qi sensation allegedly can be conducted from the needling site towards more distant sites of the body. Other techniques aim at "tonifying" (Chinese: 补; pinyin: bǔ) or "sedating" (Chinese: 泄; pinyin: xiè) qi.[53] The former techniques are used in deficiency patterns, the latter in excess patterns.[53] De qi is more important in Chinese acupuncture, while Western and Japanese patients may not consider it a necessary part of the treatment.[39] Page 5 of 44 Acupuncture - Wikipedia 12/28/2016 https://en.wikipedia.org/wiki/Acupuncture Acupressure being applied to a hand. Japanese moxibustion Related practices ◾ Acupressure, a non-invasive form of bodywork, uses physical pressure applied to acupressure points by the hand or elbow, or with various devices.[54] ◾ Acupuncture is often accompanied by moxibustion, the burning of cone-shaped preparations of moxa (made from dried mugwort) on or near the skin, often but not always near or on an acupuncture point. Traditionally, acupuncture was used to treat acute conditions while moxibustion was used for chronic diseases. Moxibustion could be direct (the cone was placed directly on the skin and allowed to burn the skin, producing a blister and eventually a scar), or indirect (either a cone of moxa was placed on a slice of garlic, ginger or other vegetable, or a cylinder of moxa was held above the skin, close enough to either warm or burn it).[55] ◾ Cupping therapy is an ancient Chinese form of alternative medicine in which a local suction is created on the skin; practitioners believe this mobilizes blood flow in order to promote healing.[56] ◾ Tui na is a TCM method of attempting to stimulate the flow of qi by various bare-handed techniques that do not involve needles.[57] ◾ Electroacupuncture is a form of acupuncture in which acupuncture needles are attached to a device that generates continuous electric pulses (this has been described as "essentially transdermal electrical nerve stimulation [TENS] masquerading as acupuncture").[58] ◾ Fire needle acupuncture also known as fire needling is a technique which involves quickly inserting a flame-heated needle into areas on the body.[59] ◾ Sonopuncture is a stimulation of the body similar to acupuncture using sound instead of needles.[60] This may be done using purpose-built transducers to direct a narrow ultrasound beam to a depth of 6–8 centimetres at acupuncture meridian points on the body.[61] Alternatively, tuning forks or other sound emitting devices are used.[62] ◾ Acupuncture point injection is the injection of various substances (such as drugs, vitamins or herbal extracts) into acupoints.[63] ◾ Auriculotherapy, commonly known as ear acupuncture, auricular acupuncture, or auriculoacupuncture, is considered to date back to ancient China. It involves inserting needles to stimulate points on the outer ear.[64] The modern approach was developed in France during the early 1950s.[64] There is no scientific evidence that it can cure disease; the evidence of effectiveness is negligible.[64] Page 6 of 44 Acupuncture - Wikipedia 12/28/2016 https://en.wikipedia.org/wiki/Acupuncture A woman receiving fire cupping in China. ◾ Scalp acupuncture, developed in Japan, is based on reflexological considerations regarding the scalp. Hand acupuncture, developed in Korea, centers around assumed reflex zones of the hand. Medical acupuncture attempts to integrate reflexological concepts, the trigger point model, and anatomical insights (such as dermatome distribution) into acupuncture practice, and emphasizes a more formulaic approach to acupuncture point location.[65] ◾ Cosmetic acupuncture is the use of acupuncture in an attempt to reduce wrinkles on the face.[66] ◾ Bee venom acupuncture is a treatment approach of injecting purified, diluted bee venom into acupoints.[67] ◾ A 2006 review of veterinary acupuncture found that there is insufficient evidence to "recommend or reject acupuncture for any condition in domestic animals".[68] Rigorous evidence for complementary and alternative techniques is lacking in veterinary medicine but evidence has been growing.[69] Effectiveness Sham acupuncture and research It is difficult but not impossible to design rigorous research trials for acupuncture.[70][71] Due to acupuncture's invasive nature, one of the major challenges in efficacy research is in the design of an appropriate placebo control group.[72][73] For efficacy studies to determine whether acupuncture has specific effects, "sham" forms of acupuncture where the patient, practitioner, and analyst are blinded seem the most acceptable approach.[70] Sham acupuncture uses non-penetrating needles or needling at non-acupuncture points,[74] e.g. inserting needles on meridians not related to the specific condition being studied, or in places not associated with meridians.[75] The under-performance of acupuncture in such trials may indicate that therapeutic effects are due entirely to non-specific effects, or that the sham treatments are not inert, or that systematic protocols yield less than optimal treatment.[76][77] A 2014 Nature Reviews Cancer review article found that "contrary to the claimed mechanism of redirecting the flow of qi through meridians, researchers usually find that it generally does not matter where the needles are inserted, how often (that is, no dose-response effect is observed), or even if needles are actually inserted. In other words, 'sham' or 'placebo' acupuncture generally produces the same effects as 'real' acupuncture and, in some cases, does better."[78] A 2013 meta-analysis found little evidence that the effectiveness of acupuncture on pain (compared to sham) was modified by the location of the needles, the number of needles used, the experience or technique of the practitioner, or by the circumstances of the sessions.[79] The same analysis also suggested that the number of needles and sessions is important, as greater numbers improved the outcomes of acupuncture compared to non- acupuncture controls.[79] There has been little systematic investigation of which components of an acupuncture session may be important for any therapeutic effect, including needle placement and depth, Page 7 of 44 Acupuncture - Wikipedia 12/28/2016 https://en.wikipedia.org/wiki/Acupuncture type and intensity of stimulation, and number of needles used.[76] The research seems to suggest that needles do not need to stimulate the traditionally specified acupuncture points or penetrate the skin to attain an anticipated effect (e.g. psychosocial factors).[2] A response to "sham" acupuncture in osteoarthritis may be used in the elderly, but placebos have usually been regarded as deception and thus unethical.[80] However, some physicians and ethicists have suggested circumstances for applicable uses for placebos such as it might present a theoretical advantage of an inexpensive treatment without adverse reactions or interactions with drugs or other medications.[80] As the evidence for most types of alternative medicine such as acupuncture is far from strong, the use of alternative medicine in regular healthcare can present an ethical question.[81] Using the principles of evidence-based medicine to research acupuncture is controversial, and has produced different results.[72] Some research suggests acupuncture can alleviate pain but the majority of research suggests that acupuncture's effects are mainly due to placebo.[9] Evidence suggests that any benefits of acupuncture are short-lasting.[15] There is insufficient evidence to support use of acupuncture compared to mainstream medical treatments.[82] Acupuncture is not better than mainstream treatment in the long term.[75] Publication bias Publication bias is cited as a concern in the reviews of randomized controlled trials (RCTs) of acupuncture.[58][83][84] A 1998 review of studies on acupuncture found that trials originating in China, Japan, Hong Kong, and Taiwan were uniformly favourable to acupuncture, as were ten out of eleven studies conducted in Russia.[85] A 2011 assessment of the quality of RCTs on TCM, including acupuncture, concluded that the methodological quality of most such trials (including randomization, experimental control, and blinding) was generally poor, particularly for trials published in Chinese journals (though the quality of acupuncture trials was better than the trials testing TCM remedies).[86] The study also found that trials published in non-Chinese journals tended to be of higher quality.[86] Chinese authors use more Chinese studies, which have been demonstrated to be uniformly positive.[87] A 2012 review of 88 systematic reviews of acupuncture published in Chinese journals found that less than half of these reviews reported testing for publication bias, and that the majority of these reviews were published in journals with impact factors of zero.[88] Specific conditions Pain The conclusions of many trials and numerous systematic reviews of acupuncture are largely inconsistent with each other.[13] A 2011 overview of high-quality Cochrane reviews suggests that acupuncture is effective for certain types of pain.[14] A 2011 systematic review of systematic reviews found that for reducing pain, real acupuncture was no better than sham acupuncture, and concluded that numerous reviews have shown little convincing evidence that acupuncture is an effective treatment for reducing Page 8 of 44 Acupuncture - Wikipedia 12/28/2016 https://en.wikipedia.org/wiki/Acupuncture pain.[10] The same review found that neck pain was one of only four types of pain for which a positive effect was suggested, but cautioned that the primary studies used carried a considerable risk of bias.[10] A 2009 overview of Cochrane reviews found acupuncture is not effective for a wide range of conditions, and suggested that it may be effective for only chemotherapy-induced nausea/vomiting, postoperative nausea/vomiting, and idiopathic headache.[13] A 2014 systematic review suggests that the nocebo effect of acupuncture is clinically relevant and that the rate of adverse events may be a gauge of the nocebo effect.[89] According to the 2014 Miller's Anesthesia book, "when compared with placebo, acupuncture treatment has proven efficacy for relieving pain".[45] A 2012 meta-analysis conducted by the Acupuncture Trialists' Collaboration found "relatively modest" efficiency of acupuncture (in comparison to sham) for the treatment of four different types of chronic pain (back and neck pain, knee osteoarthritis, chronic headache, and shoulder pain) and on that basis concluded that it "is more than a placebo" and a reasonable referral option.[90] Commenting on this meta-analysis, both Edzard Ernst and David Colquhoun said the results were of negligible clinical significance.[91][92] Edzard Ernst later stated that "I fear that, once we manage to eliminate this bias [that operators are not blind] … we might find that the effects of acupuncture exclusively are a placebo response."[93] Andrew Vickers, lead author of the original 2012 paper and chair of the Acupuncture Trialists' Collaboration, rejects that analysis, stating that the differences between acupuncture and sham acupuncture are statistically significant.[93] A 2010 systematic review suggested that acupuncture is more than a placebo for commonly occurring chronic pain conditions, but the authors acknowledged that it is still unknown if the overall benefit is clinically meaningful or cost-effective.[94] A 2010 review found real acupuncture and sham acupuncture produce similar improvements, which can only be accepted as evidence against the efficacy of acupuncture.[95] The same review found limited evidence that real acupuncture and sham acupuncture appear to produce biological differences despite similar effects.[95] A 2009 systematic review and meta- analysis found that acupuncture had a small analgesic effect, which appeared to lack any clinical importance and could not be discerned from bias.[16] The same review found that it remains unclear whether acupuncture reduces pain independent of a psychological impact of the needling ritual.[16] A 2016 Cochrane review found moderate quality evidence that real acupuncture was more effective than sham acupuncture or inactive for short-term relief of neck pain measured either upon completion of treatment or at short-term follow-up.[96] Low back A 2013 meta-analysis found that acupuncture was better than no treatment for reducing lower back pain, but not better than sham acupuncture, and concluded that the effect of acupuncture "is likely to be produced by the nonspecific effects of manipulation".[97] A 2013 systematic review found supportive evidence that real acupuncture may be more effective than sham acupuncture with respect to relieving lower back pain, but there were methodological limitations with the studies.[98] A 2013 systematic review found that acupuncture may be effective for nonspecific lower back pain, but the authors noted there were limitations in the studies examined, such as heterogeneity in study characteristics and low Page 9 of 44 Acupuncture - Wikipedia 12/28/2016 https://en.wikipedia.org/wiki/Acupuncture methodological quality in many studies.[99] A 2012 systematic review found some supporting evidence that acupuncture was more effective than no treatment for chronic non-specific low back pain; the evidence was conflicting comparing the effectiveness over other treatment approaches.[12] A 2011 overview of Cochrane reviews found inconclusive evidence regarding acupuncture efficacy in treating low back pain.[14] A 2011 systematic review of systematic reviews found that "for chronic low back pain, individualized acupuncture is not better in reducing symptoms than formula acupuncture or sham acupuncture with a toothpick that does not penetrate the skin."[10] A 2010 review found that sham acupuncture was as effective as real acupuncture for chronic low back pain.[2] The specific therapeutic effects of acupuncture were small, whereas its clinically relevant benefits were mostly due to contextual and psychosocial circumstances.[2] Brain imaging studies have shown that traditional acupuncture and sham acupuncture differ in their effect on limbic structures, while at the same time showed equivalent analgesic effects.[2] A 2005 Cochrane review found insufficient evidence to recommend for or against either acupuncture or dry needling for acute low back pain.[100] The same review found low quality evidence for pain relief and improvement compared to no treatment or sham therapy for chronic low back pain only in the short term immediately after treatment.[100] The same review also found that acupuncture is not more effective than conventional therapy and other alternative medicine treatments. [100] Headaches and migraines Two separate 2016 Cochrane reviews found that acupuncture could be useful in the prophylaxis of tension-type headaches and episodic migraines.[101][102] The 2016 Cochrane review evaluating acupuncture for episodic migraine prevention concluded that true acupuncture had a small effect beyond sham acupuncture and found moderate-quality evidence to suggest that acupuncture is at least similarly effective to prophylactic medications for this purpose.[102] A 2012 review found that acupuncture has demonstrated benefit for the treatment of headaches, but that safety needed to be more fully documented in order to make any strong recommendations in support of its use.[103] A 2009 Cochrane review of the use of acupuncture for migraine prophylaxis treatment concluded that "true" acupuncture was no more efficient than sham acupuncture, but "true" acupuncture appeared to be as effective as, or possibly more effective than routine care in the treatment of migraines, with fewer adverse effects than prophylactic drug treatment.[104] The same review stated that the specific points chosen to needle may be of limited importance.[104] A 2009 Cochrane review found insufficient evidence to support acupuncture for tension- type headaches.[104] The same review found evidence that suggested that acupuncture might be considered a helpful non-pharmacological approach for frequent episodic or chronic tension-type headache.[104] Osteoarthritis A 2014 review concluded that "current evidence supports the use of acupuncture as an alternative to traditional analgesics in osteoarthritis patients."[105] As of 2014, a meta-analysis showed that acupuncture may help osteoarthritis pain but it was noted that the effects were insignificant in comparison to sham Page 10 of 44 Acupuncture - Wikipedia 12/28/2016 https://en.wikipedia.org/wiki/Acupuncture needles.[106] A 2013 systematic review and network meta-analysis found that the evidence suggests that acupuncture may be considered one of the more effective physical treatments for alleviating pain due to knee osteoarthritis in the short-term compared to other relevant physical treatments, though much of the evidence in the topic is of poor quality and there is uncertainty about the efficacy of many of the treatments.[107] A 2012 review found "the potential beneficial action of acupuncture on osteoarthritis pain does not appear to be clinically relevant."[75] A 2010 Cochrane review found that acupuncture shows statistically significant benefit over sham acupuncture in the treatment of peripheral joint osteoarthritis; however, these benefits were found to be so small that their clinical significance was doubtful, and "probably due at least partially to placebo effects from incomplete blinding".[108] Extremity conditions A 2014 systematic review found moderate quality evidence that acupuncture was more effective than sham acupuncture in the treatment of lateral elbow pain.[109] A 2014 systematic review found that although manual acupuncture was effective at relieving short-term pain when used to treat tennis elbow, its long-term effect in relieving pain was "unremarkable".[110] A 2007 review found that acupuncture was significantly better than sham acupuncture at treating chronic knee pain; the evidence was not conclusive due to the lack of large, high-quality trials.[111] A 2011 overview of Cochrane reviews found inconclusive evidence regarding acupuncture efficacy in treating shoulder pain and lateral elbow pain.[14] Nausea and vomiting and post-operative pain A 2014 overview of systematic reviews found insufficient evidence to suggest that acupuncture is an effective treatment for postoperative nausea and vomiting (PONV) in a clinical setting.[112] A 2013 systematic review concluded that acupuncture might be beneficial in prevention and treatment of PONV. [113] A 2009 Cochrane review found that stimulation of the P6 acupoint on the wrist was as effective (or ineffective) as antiemetic drugs and was associated with minimal side effects.[112][114] The same review found "no reliable evidence for differences in risks of postoperative nausea or vomiting after P6 acupoint stimulation compared to antiemetic drugs."[114] A 2014 overview of systematic reviews found insufficient evidence to suggest that acupuncture is effective for surgical or post-operative pain.[112] For the use of acupuncture for post-operative pain, there was contradictory evidence.[112] A 2014 systematic review found supportive but limited evidence for use of acupuncture for acute post-operative pain after back surgery.[115] A 2014 systematic review found that while the evidence suggested acupuncture could be an effective treatment for postoperative gastroparesis, a firm conclusion could not be reached because the trials examined were of low quality. [116] Allergies Page 11 of 44 Acupuncture - Wikipedia 12/28/2016 https://en.wikipedia.org/wiki/Acupuncture Acupuncture is an unproven treatment for allergic-immunologic conditions.[117] A 2015 meta-analysis suggests that acupuncture might be a good option for people with allergic rhinitis (AR),[118] and a number of randomized clinical trials (RCTs) support the use of acupuncture for AR and itch.[119] There is some evidence that acupuncture might have specific effects on perennial allergic rhinitis (PAR), though all of the efficacy studies were small and conclusions should be made with caution.[120] There is mixed evidence for the symptomatic treatment or prevention of AR.[121] For seasonal allergic rhinitis (SAR), the evidence failed to demonstrate specific effects for acupuncture.[121] Using acupuncture to treat other allergic conditions such as contact eczema, drug rashes, or anaphylaxis is not recommended. [119] Cancer-related conditions A 2015 Cochrane review found that there is insufficient evidence to determine whether acupuncture is an effective treatment for cancer pain in adults.[122] A 2014 systematic review found that acupuncture may be effective as an adjunctive treatment to palliative care for cancer patients.[123] A 2013 overview of reviews found evidence that acupuncture could be beneficial for people with cancer-related symptoms, but also identified few rigorous trials and high heterogeneity between trials.[124] A 2012 systematic review of randomised clinical trials (RCTs) using acupuncture in the treatment of cancer pain found that the number and quality of RCTs was too low to draw definite conclusions.[125] A 2014 systematic review reached inconclusive results with regard to the effectiveness of acupuncture for treating cancer-related fatigue.[126] A 2013 systematic review found that acupuncture is an acceptable adjunctive treatment for chemotherapy-induced nausea and vomiting, but that further research with a low risk of bias is needed.[127] A 2013 systematic review found that the quantity and quality of available RCTs for analysis were too low to draw valid conclusions for the effectiveness of acupuncture for cancer-related fatigue.[128] A 2012 systematic review and meta-analysis found very limited evidence regarding acupuncture compared with conventional intramuscular injections for the treatment of hiccups in cancer patients.[129] The methodological quality and amount of RCTs in the review was low.[129] Dyspepsia A 2015 systematic review and meta-analysis found some evidence that acupuncture was effective for FD, but also called for further well-designed, long-term studies to be conducted to evaluate its efficacy for this condition.[130] A 2014 Cochrane review found that "it remains unknown whether manual acupuncture or electroacupuncture is more effective or safer than other treatments" for functional dyspepsia (FD).[131] Fertility and childbirth A 2014 systematic review and meta-analysis found poor quality evidence for use of acupuncture in infertile men to improve sperm motility, sperm concentration, and the pregnancy rate; the evidence was rated as insufficient to draw any conclusion regarding efficacy.[132] A 2013 Cochrane review found no Page 12 of 44 Acupuncture - Wikipedia 12/28/2016 https://en.wikipedia.org/wiki/Acupuncture evidence of acupuncture for improving the success of in vitro fertilization (IVF).[133] A 2013 systematic review found no benefit of adjuvant acupuncture for IVF on pregnancy success rates.[134] A 2012 systematic review found that acupuncture may be a useful adjunct to IVF,[135] but its conclusions were rebutted after reevaluation using more rigorous, high quality meta-analysis standards.[136] A 2012 systematic review and meta-analysis found that acupuncture did not significantly improve the outcomes of in vitro fertilization.[137] A 2011 overview of systematic reviews found that the evidence that acupuncture was effective was not compelling for most gynecologic conditions. The exceptions to this conclusion included the use of acupuncture during embryo transfer as an adjunct to in vitro fertilization. [138] Rheumatological conditions A 2013 Cochrane review found low to moderate evidence that acupuncture improves pain and stiffness in treating people with fibromyalgia compared with no treatment and standard care.[139] A 2012 review found "there is insufficient evidence to recommend acupuncture for the treatment of fibromyalgia."[75] A 2010 systematic review found a small pain relief effect that was not apparently discernible from bias; acupuncture is not a recommendable treatment for the management of fibromyalgia on the basis of this review.[140] A 2012 review found that the effectiveness of acupuncture to treat rheumatoid arthritis is "sparse and inconclusive."[75] A 2005 Cochrane review concluded that acupuncture use to treat rheumatoid arthritis "has no effect on ESR, CRP, pain, patient's global assessment, number of swollen joints, number of tender joints, general health, disease activity and reduction of analgesics."[141] A 2010 overview of systematic reviews found insufficient evidence to recommend acupuncture in the treatment of most rheumatic conditions, with the exceptions of osteoarthritis, low back pain, and lateral elbow pain.[142] Stroke A 2014 overview of systematic reviews and meta-analyses found that the evidence does not demonstrate acupuncture helps reduce the rates of death or disability after a stroke or improve other aspects of stroke recovery, such as poststroke motor dysfunction, but the evidence suggests it may help with poststroke neurological impairment and dysfunction such as dysphagia, which would need to be confirmed with future rigorous studies.[143] A 2012 review found evidence of benefit for acupuncture combined with exercise in treating shoulder pain after stroke.[144] A 2010 systematic review found that acupuncture was not effective as a treatment for functional recovery after a stroke.[145] A 2012 overview of systematic reviews found inconclusive evidence supporting the effectiveness of acupuncture for stroke.[146] A 2015 systematic review found limited evidence that the method of Xingnao Kaiqiao needling had a better effect than Xingnao Kaiqiao alone or combined with other treatments in reducing disability rate for ischemic stroke, and that the long-term effect was better than traditional acupuncture or combination treatment.[147] A 2014 meta-analysis found tentative evidence for acupuncture in cerebral infarction, a type of ischemic stroke, but the authors noted the trials reviewed were often of poor quality.[148] A 2008 Page 13 of 44 Acupuncture - Wikipedia 12/28/2016 https://en.wikipedia.org/wiki/Acupuncture Cochrane review found that evidence was insufficient to draw any conclusion about the effect of acupuncture on dysphagia after acute stroke.[149] A 2006 Cochrane review found no clear evidence for acupuncture on subacute or chronic stroke.[150] A 2005 Cochrane review found no clear evidence of benefit for acupuncture on acute stroke.[151] Sleep A 2016 systematic review and meta-analysis found that acupuncture was "associated with a significant reduction in sleep disturbances in women experiencing menopause-related sleep disturbances."[152] Other conditions For the following conditions, the Cochrane Collaboration or other reviews have concluded there is no strong evidence of benefit: alcohol dependence,[153] angina pectoris,[154] ankle sprain,[155][156] Alzheimer's disease,[157] attention deficit hyperactivity disorder,[158][159] autism,[160][161] asthma,[162][163] bell's palsy, [164][165] traumatic brain injury,[166] carpal tunnel syndrome,[167] chronic obstructive pulmonary disease, [168] cardiac arrhythmias,[169] cerebral hemorrhage,[170] cocaine dependence,[171] constipation,[172] depression,[173][174] diabetic peripheral neuropathy,[175] drug detoxification,[176][177] dry eye,[178] primary dysmenorrhoea,[179] enuresis,[180] endometriosis,[181] epilepsy,[182] erectile dysfunction,[183] essential hypertension,[184] glaucoma,[185] gynaecological conditions (except possibly fertility and nausea/vomiting),[186] hot flashes,[187][188][189] hypoxic ischemic encephalopathy in neonates,[190] insomnia,[191][192][193] induction of childbirth,[194] irritable bowel syndrome,[195] labor pain,[196][197] lumbar spinal stenosis,[198] major depressive disorders in pregnant women,[199] musculoskeletal disorders of the extremities,[200] myopia,[201] obesity,[202][203] obstetrical conditions,[204] Parkinson's disease,[205][206] polycystic ovary syndrome,[207] premenstrual syndrome,[208] preoperative anxiety,[209] psychological symptoms associated with opioid addiction,[210] restless legs syndrome,[211] schizophrenia,[212] sensorineural hearing loss,[213] smoking cessation,[214] stress urinary incontinence,[215] acute stroke,[216] stroke rehabilitation,[217] temporomandibular joint dysfunction,[218][219] tennis elbow,[220] labor induction, [221] tinnitus,[222][223] uremic itching,[224] uterine fibroids,[225] vascular dementia,[226] and whiplash.[227] Moxibustion and cupping A 2010 overview of systematic reviews found that moxibustion was effective for several conditions but the primary studies were of poor quality, so there persists ample uncertainty, which limits the conclusiveness of their findings.[228] A 2012 systematic review suggested that cupping therapy seems to be effective for herpes zoster and various other conditions but due to the high risk of publication bias, larger studies are needed to draw definitive conclusions.[229] Safety Page 14 of 44 Acupuncture - Wikipedia 12/28/2016 https://en.wikipedia.org/wiki/Acupuncture Adverse events Acupuncture is generally safe when administered by an experienced, appropriately trained practitioner using clean-needle technique and sterile single-use needles.[17][18] When improperly delivered it can cause adverse effects.[17] Accidents and infections are associated with infractions of sterile technique or neglect on the part of the practitioner.[18] To reduce the risk of serious adverse events after acupuncture, acupuncturists should be trained sufficiently.[10] People with serious spinal disease, such as cancer or infection, are not good candidates for acupuncture.[2] Contraindications to acupuncture (conditions that should not be treated with acupuncture) include coagulopathy disorders (e.g. hemophilia and advanced liver disease), warfarin use, severe psychiatric disorders (e.g. psychosis), and skin infections or skin trauma (e.g. burns).[2] Further, electroacupuncture should be avoided at the spot of implanted electrical devices (such as pacemakers).[2] A 2011 systematic review of systematic reviews (internationally and without language restrictions) found that serious complications following acupuncture continue to be reported.[10] Between 2000 and 2009, ninety-five cases of serious adverse events, including five deaths, were reported.[10] Many such events are not inherent to acupuncture but are due to malpractice of acupuncturists.[10] This might be why such complications have not been reported in surveys of adequately-trained acupuncturists.[10] Most such reports originate from Asia, which may reflect the large number of treatments performed there or a relatively higher number of poorly trained Asian acupuncturists.[10] Many serious adverse events were reported from developed countries.[10] These included Australia, Austria, Canada, Croatia, France, Germany, Ireland, the Netherlands, New Zealand, Spain, Sweden, Switzerland, the UK, and the US.[10] The number of adverse effects reported from the UK appears particularly unusual, which may indicate less under-reporting in the UK than other countries.[10] Reports included 38 cases of infections and 42 cases of organ trauma.[10] The most frequent adverse events included pneumothorax, and bacterial and viral infections.[10] A 2013 review found (without restrictions regarding publication date, study type or language) 295 cases of infections; mycobacterium was the pathogen in at least 96%.[19] Likely sources of infection include towels, hot packs or boiling tank water, and reusing reprocessed needles.[19] Possible sources of infection include contaminated needles, reusing personal needles, a person's skin containing mycobacterium, and reusing needles at various sites in the same person.[19] Although acupuncture is generally considered a safe procedure, a 2013 review stated that the reports of infection transmission increased significantly in the prior decade, including those of mycobacterium.[19] Although it is recommended that practitioners of acupuncture use disposable needles, the reuse of sterilized needles is still permitted.[19] It is also recommended that thorough control practices for preventing infection be implemented and adapted.[19] The Xingnao Kaiqiao approach appears to be a safe form of treatment.[147] Fainting was the most frequent adverse event.[147] Fainting while being treated, hematoma, and pain while being treated are associated with individual physical differences and with needle manipulation.[147] Page 15 of 44 Acupuncture - Wikipedia 12/28/2016 https://en.wikipedia.org/wiki/Acupuncture