tribute_Opmaak 1 22/03/11 09:20 Pagina 2 F, V & V inObGyn, 2011, 3 (1): 2-4 A tribute to A tribute to Robert Edwards and Howard Jones Jr “2010 was a fascinating year. Robert Edwards finally received the Nobel prize for Medicine and his friend in the United States, Howard W. Jones Jr. was honored in Denver by the American Society of Reproductive Medicine (ASRM) upon his Centennial Birthday. He turned 100 on December 30th” As the editor of “Facts, Views & Vision in ObGyn”, i am very proud to announce that Howard W. Jones Jr. accepted to be an honored member of our Editorial Board. Dr Jones is still opinionated, humble and charming, and he has still a lot to say about the past and future of ObGyn. He is still very active scientifically and two of his papers were published in our journal last year. He recently wrote a book together with Susan L. Crockin, a legal expert in the field of legal issues of assisted reproductive technologies. The book is called: Legal Conceptions: The Evolving Law and Policy of assisted reproduc- tive technologies (Fig. 1). Howard Jones Jr., is world renowned in the field of Obstetrics, Gynaecology and infertility. He pioneered iVF technologies in the US. He was born in baltimore on 30-12-1910. He received his MD in 1935 from the Johns Hopkins University School of Medicine. in 1960, Howard and his wife Georgeanna Jones became full-time faculty members at Johns Hopkins, in order to devote themselves more fully to research in gynecology and obstetrics. Howard Jones, a surgeon by the way, was doing sex change operations at Johns Hopkins and established the crytogenetics laboratory when the field was in its infancy. in the 1960s, he conducted laboratory studies of sperm and oocytes – immature eggs – with Fig. 1.— The book “Legal Conceptions: The Evolving Law and the british scientist Robert Edwards, who helped Policy of assisted reproductive technologies” by Howard Jones create the world’s first test tube baby, born in and Susan Crockin, published in 2010. England in 1978. The Joneses retired from Johns Hopkins in 1978 and were appointed professors of obstetrics and gynecology at Eastern Virginia Medical School, where they established the first in release of several eggs, would increase the odds of vitro fertilization program in the United States. He success. They had 12 failed in vitro fertilization opened the iVF clinic in norfolk in 1979. The attempts with hMG before the first patient got Joneses had 41 failures before their first success. in pregnant. The first iVF baby in the US was a fact, the days before hormones were used to prompt the due to a lot of “Views & Vision”. ovary to spew several eggs, doctors had only one egg Robert Edwards became the nobel Laureate in per month to try to fertilize. Despite general medical 2010. The british scientist who pioneered in-vitro consensus against hormone drugs at that time, fertilisation has been awarded for applying visionary, Georgeanna Jones had a hunch that hMG – human extraordinary research to change the lives of people menopausal gonadotropin – which prompts the all over the world. Human iVF has radically changed 2 tribute_Opmaak 1 22/03/11 09:20 Pagina 3 Fig. 2.— bob Edwards and Howard Jones on stage in Genk, 1995 the field of reproductive medicine. Today, 2% to 3% began his work in the 1950s, it took almost two of all newborns in many countries are conceived decades of basic scientific study of the life cycle of with the help of iVF. human eggs before Edwards and coworkers, in 1969, bob Edwards was born in 1925 in Manchester were able to successfully fertilise human eggs out- and, serving in the army in the second world war, side the human body. nine years later, in 1978, studied biology at the University of Wales in bangor Louise brown was born by caesarean section after a and at Edinburgh University. At the latter, he worked full-term pregnancy. Since more than 30 years iVF on a PhD in 1955 studying the development of became an established technique to help infertile embryos in mice. Robert Edwards developed the couples, opening new avenues of hope for millions iVF technique in a research career that started in of couples throughout the world. 1958 at the national institute for Medical Research in 2000, bob Edwards founded a new Scientific in London and continued at the world's first iVF cen- Journal called “Reproductive bioMedicine Online”. tre, the bourn Hall Clinic in Cambridge, founded Once again he showed his visionary capacities. by with the English surgeon, Patrick Steptoe. The work recognizing the increasing power of the internet, he of Robert Edwards has always been controversial but created a new style of Journal, one where abstracts he has never shrunk from confronting that contro- of submitted papers would appear online immedi- versy. He was a real visionary, and always ahead of ately, helping the scientists and researchers to his time on so many issues – not just iVF – but also publish their work more quickly than ever before. on PGD in the 60s, stem cells in the 70s, and the Once again, a true pioneer. whole process of ethical thinking. by a brilliant it’s not known why it took so long before the combination of basic and applied medical research, nobel Prize was awarded to the pioneer of iVF and Edwards overcame one technical hurdle after an- it’s regrettable that Patrick Steptoe was not recog- other in his persistence to discover a method that nized since he died in 1988. Patrick and bob formed would help to alleviate infertility. before Edwards a unique and fruitful combination of an extraordi- A TRibUTE TO – OMbELET 3 tribute_Opmaak 1 22/03/11 09:20 Pagina 4 Fig. 3.— Howard and Georgeanna Jones at their private home in norfolk (1997) nary scientist and an open-minded clinician. They enthusiasm and the richness of their visionary ideas should have shared the award! and beliefs. They inspired me and so many others … On the occasion of the 2ndmeeting of ‘Andrology in the nineties’ in 1995, i had the privilege to invite Willem Ombelet both pioneers, bob Edwards and Howard Jones, to Editor-in-Chief Genk, belgium (Fig. 2, 3). i’ll never forget their Facts, Views & Vision in ObGyn 4 F, V & V inObGyn