A Clinical Guide to Gluten-Related Disorders LWBK1260-FM_i-xviii.indd 1 21/06/13 3:29 PM LWBK1260-FM_i-xviii.indd 2 21/06/13 3:29 PM A Clinical Guide to Gluten-Related Disorders Alessio Fasano, MD Medical Director Mucosal Immunology and Biology Research Center and Center for Celiac Research Massachusetts General Hospital Division of Pediatric Gastroenterology and Nutrition Massachusetts General Hospital for Children Boston, Massachusetts LWBK1260-FM_i-xviii.indd 3 21/06/13 3:29 PM Senior Executive Editor: Rebecca S. Gaertner Product Manager: Ashley Fischer Production Product Manager: David Orzechowski Manufacturing Manager: Beth Welsh Senior Marketing Manager: Kimberly Schonberger Senior Book Designer: Joan Wendt Production Service: Aptara, Inc. © 2014 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business Two Commerce Square 2001 Market Street Philadelphia, PA 19103 USA LWW.com All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. Printed in China Library of Congress Cataloging-in-Publication Data A clinical guide to gluten-related disorders / [edited by] Alessio Fasano. — First edition. p. ; cm. Includes bibliographical references. ISBN 978-1-4511-8263-7 I. Fasano, Alessio, editor of compilation. [DNLM: 1. Celiac Disease—therapy. 2. Celiac Disease—diagnosis. 3. Celiac Disease—psychology. 4. Glutens—adverse effects. 5. Wheat Hypersensitivity—physiopathology. WD 175] RC862.C44 616.3¿99—dc23 2013017488 Care has been taken to confirm the accuracy of the information presented and to describe generally accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the publication. Application of the information in a particular situation remains the professional responsibility of the practitioner. The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new or infrequently employed drug. Some drugs and medical devices presented in the publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings. It is the responsibility of the health care provider to ascertain the FDA status of each drug or device planned for use in their clinical practice. To purchase additional copies of this book, call our customer service department at (800) 638-3030 or fax orders to (301) 223-2320. International customers should call (301) 223-2300. Visit Lippincott Williams & Wilkins on the Internet: at LWW.com. Lippincott Williams & Wilkins customer service representatives are available from 8:30 am to 6 pm, EST. 10 9 8 7 6 5 4 3 2 1 LWBK1260-FM_i-xviii.indd 4 21/06/13 3:29 PM Dedications I like to dedicate this book to all those patients affected by gluten-related disorders who look at us as the best hope to improve their quality of life. This book is also dedicated to those who are not with us anymore but who have been and continue to be a strong presence in my life. LWBK1260-FM_i-xviii.indd 5 21/06/13 3:29 PM LWBK1260-FM_i-xviii.indd 6 21/06/13 3:29 PM Contributors Carlo Catassi, MD, MPH Thomas Flass, MD, MS Professor Fortin Pediatric Specialty Clinic Department of Pediatrics St. Vincent Physician Network Università Politecnica delle Marche Billings, Montana Ancona, Italy Co-Director, Center for Celiac Research Joel Friedlander, DO, MA Massachusetts General Hospital for Children Bioethics, Assistant Professor Boston, Massachusetts Children’s Hospital Colorado Center for Celiac Disease Pam Cureton, RD, LDN Digestive Health Institute Center for Celiac Research Children’s Hospital Colorado Massachusetts General Hospital for Children University of Colorado School of Medicine Boston, Massachusetts Aurora, Colorado Valentina Discepolo, MD Stefano Guandalini, MD Pediatric Resident Professor, Department of Pediatrics Department of Pediatrics Chief, Section of Pediatric Gastroenterology, Section of Pediatric Gastroenterology, Hepatology and Nutrition Hepatology, and Nutrition University of Chicago University of Chicago Chicago, Illinois Chicago, Illinois Department of Pediatrics Ivor Hill, MB, ChB, MD Università di Napoli “Federico II” Professor of Clinical Pediatrics Naples, Italy The Ohio State University College of Medicine Division of Gastroenterology Alessio Fasano, MD Nationwide Children’s Hospital Medical Director Columbus, Ohio Mucosal Immunology and Biology Research Center and Center for Celiac Research Massachusetts General Hospital Division of Pediatric Gastroenterology and Nutrition Massachusetts General Hospital for Children Boston, Massachusetts vii LWBK1260-FM_i-xviii.indd 7 21/06/13 3:29 PM viii Contributors Edward J. Hoffenberg, MD Nomi Levy-Carrick, MD, MPhil Professor Clinical Instructor Children’s Hospital Colorado Center for Department of Psychiatry Celiac Disease New York University School of Medicine Digestive Health Institute Mental Health Director Children’s Hospital Colorado WTC Environmental Health Center University of Colorado School of Medicine Bellevue Hospital Center Aurora, Colorado New York, New York Karoly Horvath, MD, PhD Edwin Liu, MD Clinical Professor Associate Professor The Florida State University Children’s Hospital Colorado Center for Director, Celiac Center Celiac Disease Center for Digestive Health and Nutrition Digestive Health Institute Arnold Palmer Hospital for Children Children’s Hospital Colorado Orlando, Florida University of Colorado School of Medicine Aurora, Colorado Robert Kramer, MD Associate Professor Devendra I. Mehta, MD Children’s Hospital Colorado Center for Clinical Associate Professor Celiac Disease The Florida State University Digestive Health Institute Center for Digestive Health and Nutrition Children’s Hospital Colorado Arnold Palmer Hospital for Children University of Colorado School of Medicine Orlando, Florida Aurora, Colorado Sonia Kupfer, MD Naina Mehta, MD Assistant Professor Neurodevelopmental Pediatrician Department of Medicine Children’s Medical Services Division of Gastroenterology Florida Department of Health University of Chicago Orlando, Florida Chicago, Illinois Catherine Newland, MD Cynthia Kupper, RD Assistant Professor Executive Director Section of Pediatric Gastroenterology Gluten Intolerance Group Department of Pediatrics University Auburn, Washington of Iowa Iowa City, Iowa Anne Lee, MSEd, RD, LD Director of Nutritional Services Tina Rakitt, MD Dr. Schar USA, Inc. Assistant Professor Lyndhurst, New Jersey Drexel University College of Medicine Joseph Levy, MD The Children’s Hospital at Monmouth Medical Professor Center Department of Pediatrics Department of Pediatric Gastroenterology Director Long Branch, New Jersey Division of Pediatric Gastroenterology New York University School of Medicine New York, New York LWBK1260-FM_i-xviii.indd 8 22/06/13 2:54 PM Co ntributo rs ix Anna Sapone, MD, PhD Mary K. Sharrett, MS, RD, CNSC, LD Department of Gastroenterology Nationwide Children’s Hospital Experimental Medicine Department Columbus, Ohio Magrassi-Lanzara Service Second University of Naples Suzanne Simpson, RD Naples, Italy Celiac Disease Center Columbia University Yamen Smadi, MD New York, New York Gastroenterology Fellow Center for Digestive Health Tricia Thompson, MS, RD and Nutrition Founder Arnold Palmer Hospital for Children Gluten Free Watchdog, LLC Orlando, Florida Manchester, Massachusetts LWBK1260-FM_i-xviii.indd 9 21/06/13 3:29 PM LWBK1260-FM_i-xviii.indd 10 21/06/13 3:29 PM