La Jolla, CA April 17- 21 2016 hosted by the INTERNATIONAL SOCIETY FOR ANTIVIRAL RESEARCH (ISAR) Program and Abstracts TABLE of International Conference on Antiviral Research CONTENTS (ICAR) 3 Daily Schedule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Organization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Networking . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Schedule at a Glance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Women in Science Career Development Award Winners . . . . . 13 Program Schedule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95 Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR) DAILY International Conference on Antiviral Research SCHEDULE (ICAR) Sunday, April 17, 2016 › Women in Science Roundtable Luncheon › Drug Discovery & Development 101 › Welcome and Keynote Address › Opening Reception Monday, April 18, 2016 › Structural Biology Symposia › Gertrude Elion Award Lecture › Oral Sessions › Poster Session 1 › New Member and First Time Attendee Networking Reception Tuesday, April 19, 2016 › Antonin Holy Award Lecture › Oral Sessions › Shotgun Session 1 › Diagnostic Technologies Workshop › Career and Networking Happy Hour Wednesday, April 20, 2016 › William Prusoff Young Investigator Award Lecture › DNA Virus Symposia › Oral Sessions › Shotgun Session 2 › Poster Session 2 › Closing Reception and Banquet Thursday, April 21, 2016 › Clinical Session › Oral Sessions 3 Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR) International Conference on ORGANIZATION Antiviral Research (ICAR) International Society for Antiviral Research and Twenty-Ninth International Conference on Antiviral Research Officers President Robert Buckheit, Jr. Frederick, MD, USA – 2018 President-Elect Past President José Este Phillip Furman Barcelona, Spain – 2020 St . Augustine, FL, USA – 2016 Treasurer Secretary Brian Gowen Graciela Andrei Logan, UT – 2017 Leuven, Belgium – 2015 Board of Directors Andrea Brancale Jennifer Moffat William Delaney Cardiff, UK – 2016 Syracuse, NY, USA – 2017 Foster City, CA, USA – 2016 Roger Ptak Rhonda Cardin Kathie Seley-Radtke Frederick, MD, USA – 2015 Cincinnati, OH, USA – 2015 Baltimore, MD, USA – 2016 Conference Committee Chair Phil Furman Graciela Andrei Rhonda Cardin Johan Neyts Masanori Baba Jose Este Amy Patick Andrea Brancale Brian Gowen Roger Ptak Robert Buckheit, Jr. Kathie Seley-Radtke The International Society For Antiviral Research (ISAR) The Society was organized in 1987 as a non profit scientific organization for the purpose of advancing and disseminating knowledge in all areas of antiviral research . To achieve this objective, the Society organizes an annual meeting . The Society is now in its twenty ninth year of existence, and has approximately 550 members representing 30 countries . Membership application forms will also be available at the Conference Registration desk, or from our website www.isar-icar.com . 4 Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR) CONTRIBUTORS International to the Conference on 29th International Conference Antiviral Research (ICAR) on Antivral Research Confirmed Sponsors as of April 1, 2016 Platinum Gilead Sciences, Inc. Foster City, CA, USA Gold Alios BioPharma Inc., GlaxoSmithKline, Inc. part of the Janssen Pharmaceutical Companies Research Triangle Park, NC, USA South San Francisco, CA, USA Silver AbbVie Inc. ImQuest BioSciences Inc. JCR Pharmaceutical Co., Ltd. North Chicago, IL, USA Frederick, MD, USA Ashiya, Japan Chimerix Inc. Southern Research Institute Durham, NC, USA Birmingham, AL, USA Bronze ACS Infectious Diseases Elsevier B.V. Riboscience LLC Washington, DC, USA Amsterdam, The Netherlands Sunnyvale, CA, USA Antiva Biosciences Inc. Institute for Antiviral Research Toyama Chemical Co., Ltd. South San Francisco, CA, USA Utah State University, Logan, UT, USA Tokyo, Japan Center for Drug Design, Kineta Inc. XpressBio University of Minnesota Seattle, WA, USA Frederick, MD, USA Minneapolis, MN, USA Medivir AB Huddinge, Sweden Personal Contribution: Phil Furman 5 Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR) International Conference on NETWORKING Antiviral Research (ICAR) Keynote Address SUNDAY, APRIL 17, 2016 Decoding Viral Genomics in the Next Generation Era Richard Scheuermann, Ph.D. J. Craig Venter Instititute La Jolla, CA Ebola Virus: Past, Present, Future Heinz Feldmann, M.D., Ph.D. National Institute of Allergy and Infectious Diseases Hamilton, Montana, USA Networking Events Women in Science Roundtable Luncheon New Member and First Time Attendee Sunday, April 17, 2016 Networking Reception 11:30 AM – 2:00 PM Monday, April 18, 2016 FAIRWAY 1 6:30 PM – 7:30 PM FAIRWAY 1 Opening Reception Sunday, April 17, 2016 Career and Networking Happy Hour 6:00 PM – 8:00 PM Tuesday, April 19, 2016 GRANDE BALLROOM PRE-FUNCTION 5:00 PM – 6:30 PM GRANDE BALLROOM PRE-FUNCTION Conference Reception and Banquet Wednesday, April 20, 2016 7:30 PM – 10:00 PM GRANDE BALLROOM ABC 6 Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR) SCHEDULE International Conference on Antiviral Research at a GLANCE (ICAR) Sunday, April 17, 2016 TIME EVENT LOCATION 11:00 AM – 5:00 PM Registration GRANDE BALLROOM PRE-FUNCTION 11:30 AM – 2:00 PM Women In Science Roundtable Luncheon FAIRWAY 1 2:00 PM – 4:00 PM Drug Discovery & Development 101 GRANDE BALLROOM ABC 4:00 PM – 4:30 PM Coffee Break GRANDE BALLROOM PRE-FUNCTION 4:30 PM – 6:00 PM Keynote Address GRANDE BALLROOM ABC 6:00 PM – 8:00 PM Opening Reception GRANDE BALLROOM Light hors d’oeuvres served PRE-FUNCTION Monday, April 18, 2016 TIME EVENT LOCATION 7:30 AM – 5:30 PM Registration GRANDE BALLROOM PRE-FUNCTION 7:30 AM – 8:30 AM Continental Breakfast GRANDE BALLROOM PRE-FUNCTION 8:30 AM – 12:00 PM Structural Biology Symposia GRANDE BALLROOM ABC 10:00 AM – 10:30 AM Coffee Break GRANDE BALLROOM PRE-FUNCTION 12:00 PM – 1:30 PM Lunch On Your Own 1:30 PM – 2:10 PM Gertrude Elion Award Lecture GRANDE BALLROOM ABC 2:10 PM – 4:30 PM Oral Sessions – In Vitro Evaluation GRANDE BALLROOM ABC and Drug Resistance 3:00 PM – 3:30 PM Coffee Break GRANDE BALLROOM PRE-FUNCTION 4:30 PM – 6:30 PM Poster Session I GRANDE BALLROOM DE & Light hors d’oeuvres served SCRIPPS 1/2 6:30 PM – 7:30 PM New Member and First Time FAIRWAY 1 Attendee Networking Reception Light hors d’oeuvres served 7 Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR) SCHEDULE at a GLANCE Tuesday, April 19, 2016 TIME EVENT LOCATION 7:30 AM – 4:00 PM Registration GRANDE BALLROOM PRE-FUNCTION 7:30 AM – 8:30 AM Continental Breakfast GRANDE BALLROOM PRE-FUNCTION 8:30 AM – 9:00 AM Antonin Holý Award Lecture GRANDE BALLROOM ABC 9:00 AM – 10:15 AM Oral Sessions – Medicinal Chemistry GRANDE BALLROOM ABC 10:15 AM – 10:45 AM Coffee Break GRANDE BALLROOM PRE-FUNCTION 10:45 AM – 11:35 AM Oral Sessions – In Vitro Antiviral Activity GRANDE BALLROOM ABC 11:35 AM – 12:00 PM Shotgun Session 1 GRANDE BALLROOM ABC 12:00 PM – 1:30 PM Lunch On Your Own 1:30 PM – 1:45 PM International Society for GRANDE BALLROOM ABC Antiviral Research Business Meeting 1:45 PM – 2:45 PM Zika Virus GRANDE BALLROOM ABC 2:45 PM – 4:45 PM Diagnostic Technologies Symposium GRANDE BALLROOM ABC 3:15 PM – 3:45 PM Coffee Break GRANDE BALLROOM PRE-FUNCTION 6:30 PM – 8:00 PM Career and Networking Happy Hour GRANDE BALLROOM Light hors d’oeuvres served PRE-FUNCTION 8 Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR) SCHEDULE at a GLANCE Wednesday, April 20, 2016 TIME EVENT LOCATION 7:30 AM – 5:00 PM Registration GRANDE BALLROOM PRE-FUNCTION 7:30 AM – 8:30 AM Continental Breakfast GRANDE BALLROOM PRE-FUNCTION 8:30 AM – 9:00 AM William Prusoff Young Investigator Award GRANDE BALLROOM ABC 9:00 AM – 12:00 PM DNA Virus Symposia GRANDE BALLROOM ABC 9:50 AM – 10:20 AM Coffee Break GRANDE BALLROOM PRE-FUNCTION 12:00 PM – 1:30 PM Lunch On Your Own 1:30 PM – 4:30 PM Oral Sessions – Mechanism of GRANDE BALLROOM ABC Action Studies 2:50 PM – 3:20 PM Coffee Break GRANDE BALLROOM PRE-FUNCTION 4:30 PM – 6:30 PM Poster Session 2 GRANDE BALLROOM DE & Light hors d’oeuvres served SCRIPPS 1/2 7:00 PM – 7:30 PM Closing Reception GRANDE BALLROOM Light hors d’oeuvres served PRE-FUNCTION 7:30 PM – 10:00 PM Closing Banquet GRANDE BALLROOM ABC Dinner served Thursday, April 21, 2016 TIME EVENT LOCATION 7:30 AM – 12:00 PM Registration GRANDE BALLROOM PRE-FUNCTION 7:30 AM – 8:30 AM Continental Breakfast GRANDE BALLROOM PRE-FUNCTION 8:30 AM – 10:00 AM Clinical Session GRANDE BALLROOM ABC 10:00 AM – 10:30 AM Coffee Break GRANDE BALLROOM PRE-FUNCTION 10:30 AM – 11:40 AM Oral Sessions – Animal Models of Infection GRANDE BALLROOM ABC 11:40 AM – 12:00 PM Shotgun Session 2 GRANDE BALLROOM ABC 12:00 PM Conference Concludes 9 Program and Abstracts of the 29th International Conference on Antiviral Research (ICAR) ICAR Career and Networking Happy Hour Please join us for an informal career discussion and networking at the 29th ICAR meeting. This year we will again host an excellent group of moderators who are recognized experts in various areas of antiviral research and have pursued successful career in academia, government, or industry. As a part of the informal group discussion, the moderators will be ready to share their experience, answer questions, and provide feedback about career development. In addition, you will have opportunity to network with your colleagues and make new contacts. The event is open to all ICAR attendees. Please sign up during the ICAR conference at the registration desk before 8:30 AM on Tuesday, April 19. Tuesday April 19, 2016 5:00 PM – 6:30 PM ROOM: GRANDE BALLROOM PRE-FUNCTION