Professor José-Alain SAHEL Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts Date of birth: 1955/07/12 Tlemcen (Algeria) 28, rue de Charenton, 75557 Paris Cedex 12. FRANCE [email protected]. [email protected] Phone: +33 (0)1 53 46 25 04 Fax: +33 (0)1 53 46 25 05 Medical license: 75/67740 EDUCATION 1979-1980 Ophthalmology residency at A. Rothschild Foundation, Paris 1980-1984 Residency Louis Pasteur University Hospital (Neurology, Neurosurgery, Ophthalmology), Strasbourg 1980 Medical Degree-Paris University Medical School (Jury congratulations, Thesis medal) 1981 Oto-Neuro-Ophthalmologic Radiology University Degree 1984 Ophthalmology Degree – National Board Post-doctoral studies 1984-1988 Clinical fellow (Assistant), Department of Ophthalmology, Louis Pasteur University Hospital, Strasbourg 1984-1988 Chef de Clinique des Universités- - Louis Pasteur University Medical School, Strasbourg 1986-1987 Research Fellow in Ophthalmology (Pr D.M Albert)- Massachusetts Eye and Ear Infirmary - Harvard Medical School, Boston, USA Visiting Scholar in Biology (Pr J.E. Dowling) - The Harvard Biological Laboratories - Department of Cellular and Developmental Biology – Harvard University, Cambridge, Massachusetts, USA UNIVERSITY POSITIONS 1987-1992 Visiting Lecturer in Ophthalmology - Department of Ophthalmology - Harvard Medical School, Boston, Massachusetts, USA 1988-2002 University Professor of Ophthalmology – Strasbourg University (1st class since 1999) 1993-1995 Visiting Professor - Department of Ophthalmology and Visual Sciences, University of Wisconsin - Madison – USA 2001- Honorary Professor - Institute of Ophthalmology - University College London 2001- Cumberlege Chair: Professor of Biomedical Sciences - Institute of Ophthalmology-University College London 2002- University Professor of Ophthalmology – Paris (VI) Pierre and Marie Curie University Medical School (Exceptional Class) 2012-2015 Visiting Professor: Hebrew University of Jerusalem, Israel HOSPITALPOSITIONS 1988-2001 Hospital full time staff, Ophthalmology - Ophthalmological Clinic – Strasbourg University Hospital 09/2001- Hospital staff, Ophthalmology – Quinze-Vingts National Ophthalmology Hospital, Paris Chairman Department of Ophthalmology – Quinze-Vingts National Ophthalmology Hospital, Paris Chairman Department of Ophthalmology and Vitreo-retinal Diseases – Ophthalmology Foundation A. de Rothschild HOSPITAL AND UNIVERSITY ACTIVITIES 1988-2002 Director of the Eye Pathology Laboratory -Louis Pasteur University-Strasbourg 1994-2001 In charge of the Functional Unit "Segment postérieur et Oncologie" Ophtalmological Clinic – Strasbourg University Hospital 01/2005- Head of the Clinical Investigation Centre – CIC 503 INSERM Quinze-Vingts National Ophthalmology Hospital 11/2005- Director National Reference Centre for Inherited Retinal Dystrophies/CIC/ Quinze-Vingts National Ophthalmology Hospital RESEARCH ACTIVITIES 1999-2002 Head of INSERM EMI 99-18 – UPRES EA 24-10:Cellular and Molecular Physiopathology of the retina –Louis Pasteur University, Strasbourg 2002- Head of UMR INSERM-UPMC 592: Cellular and Molecular Physiopathology of the retina, St-Antoine Hospital, Paris 2003- Co-foundator of European Vision Institute, EEIG 2004-2007 Scientific Director of the Scientific Interest Group-VISION, Paris 2005-2007 Coordinator of the Vision Research National Program (Inserm).(Sensory organs since 2007). 2005-2008 Scientific director of the Vision Institute project – CHNO des Quinze-Vingts 2006- Director of the “Seeing and Hearing” Institut Carnot (Vision Institute in conjunction with the Department of Neurosciences Chaired by Christine Petit at Institut Pasteur) 2006- Director of the “Seeing and Hearing” Scientific Cooperation Foundation 2007-2017 Coordinator of the Foundation Fighting Blindness Paris Research Centre 2009- Director of the Research Centre Vision Institute, UMR S 968 Inserm/Université Pierre et Marie Curie and UMR 7210 CNRS 2011- Director of the Laboratory of Excellence "LIFESENSES: senses for a lifetime" 1 EUROPEAN RESEARCH PROGRAMS 2000-2003 Coordinator of the concerted action NeuroPROtection in the RETina/PRORET/FP5 (QLK6-CT-2000-00569) 2001-2004 Coordinator of the R&D program PROtection against AGEing in the RETina/PRO-AGE-RET/FP5 (QLK6-CT- 2001- 00385) 2005-2009 Coordinator of the Integrated project Functional GENOmic of the RETina-EVI-GENORET, the largest Vision Project ever funded by EU (FP6- 512036) 2010-2013 Coordinator of the RdCVF program (orphan drug/rare diseases), (FP7 HEALTH-F2-2010-241683) 2010-2014 Deputy Coordinator of the European research network Treatrush (FP7 HEALTH-F2-2010-242013) 2014-2020 Coordinator of the European Research Council Synergy Grant “HELMHOLTZ” PRIZES and AWARDS Thesis medal (1980), IPSEN Foundation International Prize (1985), Fondation pour la recherche thérapeutique (1986), Research To Prevent Blindness International Scholar Award (1990),Research Prize of the French Society of Ophthalmology (1990),Prix de parrainage de la Fondation Alsace (1994),Ophthalmologist of the Year 1998 (Abstract Ophthalmo, Paris) (1998),Mérite Typhlophile Gold Medal (fight against blindness) (2001), Foundation Bettencourt Schueller 'Coups d'élan pour la Recherche Française' Prize (2002), Knight of the National Order of Merit (2003), Foundation Fighting Blindness (FFB) Trustee Award (2005), Emilia Valori Grand Prix of the French Academy of Sciences (2005), The Institut de France’s Foundation NRJ Grand Prix scientifique (2006), Alcon Research Institute Alumni Award for Excellence in Vision Research (2006), The Altran Foundation Innovation Award(2007),Quebec Vision Research Network's Prize(Canada) (2007), Gold Medal of the University Pierre et Marie Curie (2008), Knight of the Legion of Honor(2008), Honoris Causa Doctorate from the University of Geneva (2010), Coscas Medal, Retina 2012, Rome (2012),Jules Gonin lecture, Prize of the of the Retina Research Foundation, Reykjavik (2012), CNRS Medal of Innovation (2012), Officer of the National Order of Merit (France) (2012), ARVO Silver Fellow (2013), Prix La Recherche (2013), Prix Inter-Optiques de la Filière de la Vision (2014), Prix Chaptal of the French Industry (2014), Special Recognition Award Retina International (2014), Foundation Fighting Blindness (FFB) Llura Liggett Gund Award (2015), Prix Opecst-Inserm (2015), Prix Alfred Monnier (2015) Elected to the European Academy of Ophthalmology (2006), the Academia Ophthalmologia Internationalis (2007), the Academy of Sciences-Institut de France (2007), the German National Academy of Sciences Leopoldina (2014) More than 300 invited lectures, including the Wilmer lecture (Johns Hopkins, 2003), The Leopold lecture (Irvine, Ca, 2007), The Euretina lecture (Vienna, 2008), ARVO (and pre-ARVO) symposia, the Leopoldina Academy (2009), College de France, Pasteur Institute, Hadassah University, the German, French, Israeli societies for Neuroscience, NIHR (UK), ISOPT, ISOCB, ISER, ESF, Jules Gonin Lecture of the Retina Research Foundation, Reykjavik (2012), Brain Prize meetings lectures (2012, 2014), FENS (2014), Stanford University (2015), From Neural Circuitry to Neurotechnology (AAAS, Riken Institute, Tokyo, 2015), Keynote XVIIth International Meeting on Retinal Degeneration , Kyoto, Japan,… SCIENTIFIC ADVISORY BOARD 1999-2003 Vice-Chairman of the Neuroscience Commission – CSS4 Inserm 2000- Member of the Scientific Advisory Board Foundation Fighting Blindness – (FFB), ESAB member since 2012 2002-2006 Member of the Scientific Advisory Board Neurotech 2002- Member of the Scientific Advisory Board - Fédération des Aveugles et handicapés Visuels de France (FAF) 2003- Member of the Steering Committee - European Vision Institute (EVI EEIG) 2004- Member of the Steering Committee - European Vision Institute- Clinical Trials – Sites of excellence (EVI-CT-SE), Chairman since 2011 2003-2007 Member of the Scientific Advisory Board AP-HP 2003-2007 Member of the Scientific Advisory Board - Génopoles 2004-2007 Member of the Scientific Advisory Board - AGF Athena 2004- Ad hocConsultant by Alcon, Sanofi, Novartis, Pfizer 2005- Chairman of the Scientific Advisory Board - Fovea pharmaceuticals 2006- Chairman of the Scientific Advisory Board - Genesignal 2007-2008 Member of the Scientific Advisory Board - Bourse Lavoisier 2007-2009 Responsable Thématique Neurosciences- Pôle de compétitivité Medicen 2007-2009 Member of the Scientific Advisory Board ERAB Allergan 2007- Chairman of the Scientific Advisory Board - Fédération des Aveugles et Handicapés Visuels de France (FAF) 2007- Member of the recrutment committee (Commission des effectifs de la) faculté de Médecine Pierre et Marie Curie 2007-2013 Member of Scientific Advisory Board - Faculté de Médecine Pierre et Marie Curie University 2007- Coordinator Expert Committee « Retina » and Scientific Section « Retina » - EVI-CT-SE 2008-2011 Member of the Scientific Advisory Board, Alcon Research Institute 2008- Member of the Scientific Advisory Board Euretina 2008- Honorary Member of the Deutsche Opththalmologische Gesellschaft (DOG) 2008- Member of the Scientific Advisory Board - Ville de Paris 2009- Memberthe Scientific Advisory Board - Optic 2000 Foundation 2 2009 Member of the Scientific Advisory Board - E-Sidor 2009- 2010 Member of the Scientific Advisory Board - Cellectis 2009-2010 Member of the Scientific and Medical Advisory Board - Mutualité Française 2010-2011 Member of the Scientific Committee – Fondation pour la Recherche Médicale 2010-2013 Member of the Scientific Committee – ARIIS (Alliance pour la Recherche et l'Innovation des Industries de Santé) 2010 Chairman of the Scientific Advisory Board – Ophtimalia 2010- Member of the Scientific Committee – L’Association Française de l’Eclairage (AFE) 2012- Member of the Scientific Committee “ArguSanté” Institut de France 2012- Member of the Group of Experts "Regional and national system of transfer and innovation at the Minister of education and research 2013- Member of the Innovation 2030 national committee 2013- Member of the Steering Committee of the Translational Research Program in Health (The French National Research Agency) 2014- Member of the Scientific Advisory Board of the Choroideremia Research Foundation 2014- Member of the Scientific Advisory Board of the Fondation NRJ de l’Institut de France2014- Member of the Scientific Advisory Board, Vision Medicines 2014- Member of the Steering Committee for development of a series of Coursera (digital) courses around the brain in cooperation among Israeli, French, Swiss and Portuguese institutions 2015- Chairman of the Scientific Advisory Board - Group Point Vision ORGANIZATION OF INTERNATIONAL CONFERENCES April 2002 Consensus Conference (Foundation Fighting Blindness, Inserm, AFM) “Clinical Trials Orphan Retinal Degenerations”, Paris, France April 2005 “Ophthalmic Pan-European Clinical Trials and the Impact of EU Directive” Royal Society of Medicine, London, UK July 2007 “Hearing and seeing: Fighting sensory disabilities” Collège de France, Paris, France January 2008 2nd European eAccessibility Forum “Accessible e-books: an opportunity for the disabled”, Paris, France December 2008 Fondation Singer-Polignac/“Seeing and Hearing” Foundation/Institute of Ophthalmology UCL/Institut de la Vision Symposium “Fighting blinding diseases: towards a joint endeavour” Paris, France November 2009 ESF-UB Conference in Biomedicine in association with Eurovisionnet and Fondation Voir et Entendre “Rare Diseases II: Hearing and sight loss”, Sant Feliu de Guixols, Spain April 2014 Symposium “Stem Cell and Gene Therapy”, World Ophthalmology Congress, Tokyo, Japan July 2014 Symposium "Cell and Gene Therapy Approaches in Retinal Degenerations", FENS Forum, Milan Italy July 2015 Symposium “Gene Therapy”, ISOPT Clinical meeting, Berlin, Germany JOURNAL EDITORIAL BOARDS The Journal of Clinical Investigation Science Translational Medicine Progress in Retinal and Eye Research Journal Français d'Ophtalmologie Orphanet Journal of Rare Diseases Survey of Ophthalmology JAMA Ophthalmology Chinese Journal of Clinicians Intractable & Rare Diseases Research (Co-Editor-in Chief) Translational Vision Science and Technology Ophthalmology and Therapy PUBLICATIONS, REVIEWS, EDITORIALS, BOOKS PUBLICATIONS 2015 Schmitz-Valckenberg S, Sahel JA, Danis R, Fleckenstein M, Jaffe GJ, Wolf S, Pruente C, Holz FG. Natural History of Geographic Atrophy Progression Secondary to Age-Related Macular Degeneration (Geographic Atrophy Progression Study). Ophthalmology. 2015 Nov 3. [Epub ahead of print] 3 Bizet AA, Becker-Heck A, Ryan R, Weber K, Filhol E, Krug P, Halbritter J, Delous M, Lasbennes MC, Linghu B, Oakeley EJ, Zarhrate M, Nitschké P, Garfa-Traore M, Serluca F, Yang F, Bouwmeester T, Pinson L, Cassuto E, Dubot P, Elshakhs NA, Sahel JA, Salomon R, Drummond IA, Gubler MC, Antignac C, Chibout S, Szustakowski JD, Hildebrandt F, Lorentzen E, Sailer AW, Benmerah A, Saint-Mezard P, Saunier S. Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization. Nat Commun. 2015 Oct 21;6:8666. Léveillard T, Van Dorsselaer A, Sahel JA. [Altruism in the retina: sticks feed cones]. Med Sci (Paris). 2015 Oct;31(10):828-30. Tick S, Wolff B, Tilleul-Hatwell V, Sahel JA, Cohen SY. Inner Retinal Refractile Lesions in Type 1 Neurofibromatosis. Retina. 2015 Oct 16. [Epub ahead of print] Levy O, Lavalette S, Hu SJ, Housset M, Raoul W, Eandi C, Sahel JA, Sullivan PM, Guillonneau X, Sennlaub F. APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. J Neurosci. 2015 Oct 7;35(40):13568-76. Roubeix C, Godefroy D, Mias C, Sapienza A, Riancho L, Degardin J, Fradot V, Ivkovic I, Picaud S, Sennlaub F, Denoyer A, Rostene W, Sahel JA, Parsadaniantz SM, Brignole-Baudouin F, Baudouin C. Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma. Stem Cell Res Ther. 2015 Sep 16;6:177. Audo I, Gocho K, Rossant F, Mohand-Saïd S, Loquin K, Bloch I, Sahel JA, Paques M. Functional and high-resolution retinal imaging monitoring photoreceptor damage in acute macular neuroretinopathy. Graefes Arch Clin Exp Ophthalmol. 2015 Sep 7. [Epub ahead of print] Arteni AA, Fradot M, Galzerano D, Mendes-Pinto MM, Sahel JA, Picaud S, Robert B, Pascal AA. Structure and Conformation of the Carotenoids in Human Retinal Macular Pigment. PLoS One. 2015 Aug 27;10(8):e0135779. Azoulay L, Chaumet-Riffaud P, Jaron S, Roux C, Sancho S, Berdugo N, Audo I, Sahel JA, Mohand-Saïd S. Threshold Levels of Visual Field and Acuity Loss Related to Significant Decreases in the Quality of Life and Emotional States of Patients with Retinitis Pigmentosa. Ophthalmic Res. 2015 Jul 29;54(2):78-84. [Epub ahead of print] Bendali A, Rousseau L, Lissorgues G, Scorsone E, Djilas M, Dégardin J, Dubus E, Fouquet S, Benosman R, Bergonzo P, Sahel JA, Picaud S. Synthetic 3D diamond-based electrodes for flexible retinal neuroprostheses: Model, production and in vivo biocompatibility. Biomaterials. 2015 Jul 14;67:73-83. Dominguez E, Raoul W, Calippe B, Sahel JA, Guillonneau X, Paques M, Sennlaub F. Experimental Branch Retinal Vein Occlusion Induces Upstream Pericyte Loss and Vascular Destabilization. PLoS One. 2015 Jul 24;10(7):e0132644. Cahuzac A, Scemama C, Mauget-Faÿsse M, Sahel JA, Wolff B. Retinal arterial macroaneurysms: clinical, angiographic, and tomographic description and therapeutic management of a series of 14 cases. Eur J Ophthalmol. 2015 Jul 2:0. doi: 10.5301/ejo.5000641. [Epub ahead of print] Ho AC, Humayun MS, Dorn JD, da Cruz L, Dagnelie G, Handa J, Barale PO, Sahel JA, Stanga PE, Hafezi F, Safran AB, Salzmann J, Santos A, Birch D, Spencer R, Cideciyan AV, de Juan E, Duncan JL, Eliott D, Fawzi A, Olmos de Koo LC, Brown GC, Haller JA, Regillo CD, Del Priore LV, Arditi A, Geruschat DR, Greenberg RJ; Argus II Study Group. Long-Term Results from an Epiretinal Prosthesis to Restore Sight to the Blind. Ophthalmology. 2015 Aug;122(8):1547-54. doi: 10.1016/j.ophtha.2015.04.032. Epub 2015 Jul 8. Cases O, Joseph A, Obry A, Santin MD, Ben-Yacoub S, Pâques M, Amsellem-Levera S, Bribian A, Simonutti M, Augustin S, Debeir T, Sahel JA, Christ A, de Castro F, Lehéricy S, Cosette P, Kozyraki R. Foxg1-Cre Mediated Lrp2 Inactivation in the Developing Mouse Neural Retina, Ciliary and Retinal Pigment Epithelia Models Congenital High Myopia. PLoS One. 2015 Jun 24;10(6):e0129518. Boulanger-Scemama E, El Shamieh S, Démontant V, Condroyer C, Antonio A, Michiels C, Boyard F, Saraiva JP, Letexier M, Souied E, Mohand-Saïd S, Sahel JA, Zeitz C, Audo I. Next-generation sequencing applied to a large French cone and cone-rod dystrophy cohort: mutation spectrum and new genotype-phenotype correlation. Orphanet J Rare Dis. 2015 Jun 24;10(1):85. 4 Launay PS, Godefroy D, Khabou H, Rostene W, Sahel JA, Baudouin C, Melik Parsadaniantz S, Reaux-Le Goazigo A. Combined 3DISCO clearing method, retrograde tracer and ultramicroscopy to map corneal neurons in a whole adult mouse trigeminal ganglion. Exp Eye Res. 2015 Jun 11. pii: S0014-4835(15)00196-7. Cwerman-Thibault H, Augustin S, Lechauve C, Ayache J, Ellouze S, Sahel JA, Corral-Debrinski M. Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss. Mol Ther Methods Clin Dev. 2015 Feb 25;2:15003. Orhan E, Dalkara D, Neuillé M, Lechauve C, Michiels C, Picaud S, Léveillard T, Sahel JA, Naash MI, Lavail MM, Zeitz C, Audo I. Genotypic and phenotypic characterization of P23H line 1 rat model. PLoS One. 2015 May 26;10(5):e0127319. Orieux G, Slembrouck A, Bensaïd M, Sahel JA, Goureau O. The protein tyrosine phosphatase interacting protein 51 (PTPIP51) is required for the differentiation of photoreceptors. Neuroscience. 2015 Aug 6;300:276-85. Neuillé M, Morgans CW, Cao Y, Orhan E, Michiels C, Sahel JA, Audo I, Duvoisin RM, Martemyanov KA, Zeitz C. LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation. Eur J Neurosci. 2015 May 22. doi: 10.1111/ejn.12959. [Epub ahead of print] Aït-Ali N, Fridlich R, Millet-Puel G, Clérin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier- Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, Dalkara D, van Dorsselaer A, Sahel JA, Léveillard T. Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis. Cell. 2015 May 7;161(4):817-32. Hu SJ, Calippe B, Lavalette S, Roubeix C, Montassar F, Housset M, Levy O, Delarasse C, Paques M, Sahel JA, Sennlaub F, Guillonneau X. Upregulation of P2RX7 in Cx3cr1-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1(cid:0) Secretion and Photoreceptor Neurodegeneration. J Neurosci. 2015 May 6;35(18):6987-96. Vacca O, El Mathari B, Darche M, Sahel JA, Rendon A, Dalkara D. Using Adeno-associated Virus as a Tool to Study Retinal Barriers in Disease. J Vis Exp. 2015 Apr 19;(98). doi: 10.3791/52451. El Mathari B, Sene A, Charles-Messance H, Vacca O, Guillonneau X, Grepin C, Sennlaub F, Sahel JA, Rendon A, Tadayoni R. Dystrophin Dp71 gene deletion induces retinal vascular inflammation and capillary degeneration. Hum Mol Genet. 2015 Apr 21. pii: ddv132. [Epub ahead of print] Martins J, Kolomiets B, Caplette R, Sahel JA, Castelo-Branco M, Ambrósio AF, Picaud SA. Sildenafil acutely decreases visual responses in ON and OFF retinal ganglion cells. Invest Ophthalmol Vis Sci. 2015 Mar 26. pii: IOVS-14-15964. doi: 10.1167/iovs.14-15964. [Epub ahead of print] Duebel J, Marazova K, Sahel JA. Optogenetics. Curr Opin Ophthalmol. 2015 May;26(3):226-32. (review) El Shamieh S, Boulanger-Scemama E, Lancelot ME, Antonio A, Démontant V, Condroyer C, Letexier M, Saraiva JP, Mohand- Saïd S, Sahel JA, Audo I, Zeitz C. Targeted next generation sequencing identifies novel mutations in RP1 as a relatively common cause of autosomal recessive rod-cone dystrophy. Biomed Res Int. 2015;2015:485624. Berger A, Lorain S, Joséphine C, Desrosiers M, Peccate C, Voit T, Garcia L, Sahel JA, Bemelmans AP. Repair of rhodopsin mRNA by spliceosome-mediated RNA trans-splicing: a new approach for autosomal dominant retinitis pigmentosa. Mol Ther. 2015 May;23(5):918-30. Magnain C, Castel A, Boucneau T, Simonutti M, Ferezou I, Rancillac A, Vitalis T, Sahel JA, Paques M, Atlan M. Holographic laser Doppler imaging of microvascular blood flow. J Opt Soc Am A Opt Image Sci Vis. 2014 Dec 1;31(12):2723-35. Errera MH, Levinson RD, Fardeau C, Thomas D, Cohen D, Navarro A, Héron E, Paques M, Pavesio C, Sahel JA, Westcott MC, Gaudric A, LeHoang P, Bodaghi B. Late posterior segment relapses in a series of Vogt-Koyanagi-Harada disease. Acta Ophthalmol. 2015 Sep;93(6):e509-10. Levy O, Calippe B, Lavalette S, Hu SJ, Raoul W, Dominguez E, Housset M, Paques M, Sahel JA, Bemelmans AP, Combadiere C, Guillonneau X, Sennlaub F. Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration. EMBO Mol Med. 2015 Jan 20;7(2):211-26. 5 Elachouri G, Lee-Rivera I, Clérin E, Argentini M, Fridlich R, Blond F, Ferracane V, Yang Y, Raffelsberger W, Wan J, Bennett J, Sahel JA, Zack DJ, Léveillard T. Thioredoxin rod-derived cone viability factor protects against photooxidative retinal damage. Free Radic Biol Med. 2015 Apr;81:22-9. Dalkara D, Duebel J, Sahel JA.Gene therapy for the eye focus on mutation-independent approaches. Curr Opin Neurol. 2015 Feb;28(1):51-60. (review) Manes G, Guillaumie T, Vos WL, Devos A, Audo I, Zeitz C, Marquette V, Zanlonghi X, Defoort-Dhellemmes S, Puech B, Said SM, Sahel JA, Odent S, Dollfus H, Kaplan J, Dufier JL, Le Meur G, Weber M, Faivre L, Cohen FB, Béroud C, Picot MC, Verdier C, Sénéchal A, Baudoin C, Bocquet B, Findlay JB, Meunier I, Dhaenens CM, Hamel CP.High Prevalence of PRPH2 in Autosomal Dominant Retinitis Pigmentosa in France and Characterization of Biochemical and Clinical Features.Am J Ophthalmol.2015 Feb;159(2):302-14. Bujakowska KM, Zhang Q, Siemiatkowska AM, Liu Q, Place E, Falk MJ, Consugar M, Lancelot ME, Antonio A, Lonjou C, Carpentier W, Mohand-Saïd S, den Hollander AI, Cremers FP, Leroy BP, Gai X, Sahel JA, van den Born LI, Collin RW, Zeitz C, Audo I, Pierce EA. Mutations in IFT172 cause isolated retinal degeneration and Bardet-Biedl syndrome. Hum Mol Genet.2015 Jan 1;24(1):230-42. Macé E, Caplette R, Marre O, Sengupta A, Chaffiol A, Barbe P, Desrosiers M, Bamberg E, Sahel JA, Picaud S, Duebel J, Dalkara D.Targeting Channelrhodopsin-2 to ON-bipolar Cells With Vitreally Administered AAV Restores ON and OFF Visual Responses in Blind Mice.Mol Ther. 2015 Jan;23(1):7-16. 2014 Clérin E, Yang Y, Forster V, Fontaine V, Sahel JA, Léveillard T. Vibratome sectioning mouse retina to prepare photoreceptor cultures. J Vis Exp. 2014 Dec 22;(94). Law AL, Parinot C, Chatagnon J, Gravez B, Sahel JA, Bhattacharya SS, Nandrot EF. Cleavage of Mer Tyrosine Kinase (MerTK) from the Cell Surface Contributes to the Regulation of Retinal Phagocytosis.J Biol Chem. 2014 Dec 23. [Epub ahead of print] Fort PE, Darche M, Sahel JA, Rendon A, Tadayoni R. Lack of dystrophin protein Dp71 results in progressive cataract formation due to loss of fiber cell organization.Mol Vis. 2014 Nov 4;20:1480-90. Mora P, Ghirardini S, Héron E, Sedira N, Olcelli F, Gandolfi S, Sahel JA, Errera MH. Ocular tuberculosis: experience of an Italian and French cohort.Acta Ophthalmol.2014 Dec 9. [Epub ahead of print] Byrne LC, Dalkara D, Luna G, Fisher SK, Clérin E, Sahel JA, Léveillard T, Flannery JG.Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration.J Clin Invest.2014 Nov 21.[Epub ahead of print] Sabbah N, Authié CN, Sanda N, Mohand-Said S, Sahel JA, Safran AB.Importance of Eye Position on Spatial Localization in Blind Subjects Wearing an Argus II Retinal Prosthesis.Invest Ophthalmol Vis Sci. 2014 Nov 20;55(12):8259-66. Boillot T, Rosolen SG, Dulaurent T, Goulle F, Thomas P, Isard PF, Azoulay T, Lafarge-Beurlet S, Woods M, Lavillegrand S, Ivkovic I, Neveux N, Sahel JA, Picaud S, Froger N.Determination of morphological, biometric and biochemical susceptibilities in healthy Eurasier dogs with suspected inherited glaucoma.PLoS One. 2014 Nov 7;9(11):e111873. Szikra T, Trenholm S, Drinnenberg A, Jüttner J, Raics Z, Farrow K, Biel M, Awatramani G, Clark DA, Sahel JA, da Silveira RA, Roska B.Rods in daylight act as relay cells for cone-driven horizontal cell-mediated surround inhibition.Nat Neurosci. 2014 Dec;17(12):1728-35. Sahel JA, Marazova K, Audo I. Clinical Characteristics and Current Therapies for Inherited Retinal Degenerations.Cold Spring Harb Perspect Med. 2014 Oct 16. pii: a017111. [Epub ahead of print] Ratnapriya R, Zhan X, Fariss RN, Branham KE, Zipprer D, Chakarova CF, Sergeev YV, Campos MM, Othman M, Friedman JS, Maminishkis A, Waseem NH, Brooks M, Rajasimha HK, Edwards AO, Lotery A, Klein BE, Truitt BJ, Li B, Schaumberg DA, Morgan DJ, Morrison MA, Souied E, Tsironi EE, Grassmann F, Fishman GA, Silvestri G, Scholl HP, Kim IK, Ramke J, Tuo J, Merriam JE, Merriam JC, Park KH, Olson LM, Farrer LA, Johnson MP, Peachey NS, Lathrop M, Baron RV, Igo RP Jr, Klein R, Hagstrom SA, Kamatani Y, Martin TM, Jiang Y, Conley Y, Sahel JA, Zack DJ, Chan CC, Pericak-Vance MA, Jacobson SG, Gorin 6 MB, Klein ML, Allikmets R, Iyengar SK, Weber BH, Haines JL, Léveillard T, Deangelis MM, Stambolian D, Weeks DE, Bhattacharya SS, Chew EY, Heckenlively JR, Abecasis GR, Swaroop A. Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration. Hum Mol Genet. 2014 Nov 1;23(21):5827-37. Reichman S, Terray A, Slembrouck A, Nanteau C, Orieux G, Habeler W, Nandrot EF, Sahel, JA, Monville C, Goureau O. From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium. PNAS, Proceedings of the National Academy of Sciences 2014, 2014 Jun 10;111(23):8518-23. De Bats F, Wolff B, Vasseur V, Affortit A, Kodjikian L, Sahel JA, Mauget-Faÿsse M. "En-face" spectral-domain optical coherence tomography findings in multiple evanescent white dot syndrome. J Ophthalmol. 2014;2014:928028. Berger A, Cavallero S, Dominguez E, Barbe P, Simonutti M, Sahel JA, SennlaubF, Raoul W, Paques M, Bemelmans AP. Spectral- domain optical coherence tomography of the rodent eye: highlighting layers of the outer retina using signal averagingand comparison with histology. PLoS One. 2014 May 2;9(5):e96494. Vaidya A, Borgonovi E, Taylor RS, Sahel JA, Rizzo S, Stanga PE, Kukreja A,Walter P. The cost-effectiveness of the Argus II retinal prosthesis in Retinitis Pigmentosa patients.BMC Ophthalmol. 2014 Apr 14;14:49. Froger N, Moutsimilli L, Cadetti L, Jammoul F, Gaucher D, Rosolen SG, NeveuxN, Cynober L, Sahel JA, Picaud S. Taurine: The comeback of a neutraceutical inthe prevention of retinal degenerations. Prog Retin Eye Res. 2014 Apr 8. Picaud S, Sahel JA. Retinal prostheses: clinical results and futurechallenges. C R Biol. 2014 Mar;337(3):214-22. Léveillard T, Fridlich R, Clérin E, Aït-Ali N, Millet-Puel G, Jaillard C, YangY, Zack D, van-Dorsselaer A, Sahel JA. Therapeutic strategy for handlinginherited retinal degenerations in a gene-independent manner using rod-derivedcone viability factors. C R Biol. 2014 Mar;337(3):207-13. Cwerman-Thibault H, Augustin S, Ellouze S, Sahel JA, Corral-Debrinski M. Gene therapy for mitochondrial diseases: Leber Hereditary Optic Neuropathy as thefirst candidate for a clinical trial. C R Biol. 2014 Mar;337(3):193-206. Dalkara D, Sahel JA.Gene therapy for inherited retinal degenerations.C R Biol. 2014 Mar;337(3):185-92. Sahel JA. Spotlight on vision.C R Biol. 2014 Mar;337(3):151. Wolff B, Azar G, Vasseur V, Sahel JA, Vignal C, Mauget-Faÿsse M. Microcystic changes in the retinal internal nuclear layer associated with optic atrophy: aprospective study. J Ophthalmol. 2014;2014:395189. Bendali A, Bouguelia S, Roupioz Y, Forster V, Mailley P, Benosman R, Livache T, Sahel JA, Picaud S. Cell specific electrodes for neuronal networkreconstruction and monitoring. Analyst. 2014 Apr 4. El Shamieh S, Neuillé M, Terray A, Orhan E, Condroyer C, Démontant V, Michiels C, Antonio A, Boyard F, Lancelot ME, Letexier M, Saraiva JP, Léveillard T, Mohand-Saïd S, Goureau O, Sahel JA, Zeitz C, Audo I. Whole-exome sequencingidentifies KIZ as a ciliary gene associated with autosomal-recessive rod-conedystrophy. Am J Hum Genet. 2014 Apr 3;94(4):625-33. Bendali A, Agnès C, Meffert S, Forster V, Bongrain A, Arnault JC, Sahel JA,Offenhäusser A, Bergonzo P, Picaud S. Distinctive glial and neuronal interfacing on nanocrystalline diamond. PLoS One. 2014 Mar 24;9(3):e92562. Sanda N, Heran F, Daly-Schveitzer N, Sahel JA, Safran AB. Increased opticnerve radiosensitivity following optic neuritis. Neurology. 2014 Apr22;82(16):1474-5. Lechauve C, Augustin S, Cwerman-Thibault H, Reboussin E, Roussel D, Lai-Kuen R, Saubamea B, Sahel JA, Debeir T, Corral- Debrinski M. Neuroglobin Gene TherapyPrevents Optic Atrophy and Preserves Durably Visual Function in Harlequin Mice.Mol Ther. 2014 Mar 13. Neuillé M, El Shamieh S, Orhan E, Michiels C, Antonio A, Lancelot ME,Condroyer C, Bujakowska K, Poch O, Sahel JA, Audo I, Zeitz C. Lrit3 deficientmouse (nob6): a novel model of complete congenital stationary night blindness(cCSNB). PLoS One. 2014 Mar 5;9(3):e90342. 7 Errera MH, Coisy S, Fardeau C, Sahel JA, Kallel S, Westcott M, Bodaghi B,Paques M. Retinal Vasculitis Imaging by Adaptive Optics.Ophthalmology. 2014 Feb 25.pii: S0161-6420(13)01257-8. Orieux G, Picault L, Slembrouck A, Roger JE, Guillonneau X, Sahel JA, Saule S, McPherson JP, Goureau O. Involvement of Bcl- 2-associated transcription factor 1 in the differentiation of early-born retinal cells. J Neurosci. 2014 Jan 22;34(4):1530-41. Koch E, Rosenbaum D, Brolly A, Sahel JA, Chaumet-Riffaud P, Girerd X, RossantF, Paques M. Morphometric analysis of small arteries in the human retina usingadaptive optics imaging: relationship with blood pressure and focal vascularchanges. J Hypertens. 2014 Apr;32(4):890-8. Vacca O, Darche M, Schaffer DV, Flannery JG, Sahel JA, Rendon A, Dalkara D.AAV-mediated gene delivery in Dp71-null mouse model with compromised barriers.Glia. 2014 Mar;62(3):468-76. Sahel JA, Marazova K. Toward postnatal reversal of ocular congenitalmalformations. J Clin Invest. 2014 Jan 2;124(1):81-4. Faure C, Gocho K, Le Mer Y, Sahel JA, Paques M, Audo I. Functional and highresolution retinal imaging assessment in a case of ocular siderosis. Doc Ophthalmol. 2014 Feb;128(1):69-75. 2013 Kermorvant-Duchemin E, Pinel AC, Lavalette S, Lenne D, Raoul W, Calippe B, Behar-Cohen F, Sahel JA, Guillonneau X, Sennlaub F. Neonatal hyperglycemiainhibits angiogenesis and induces inflammation and neuronal degeneration in theretina. PLoS One. 2013 Nov 21;8(11):e79545. Orhan E, Prézeau L, El Shamieh S, Bujakowska KM, Michiels C, Zagar Y, Vol C, Bhattacharya SS, Sahel JA, Sennlaub F, Audo I, Zeitz C. Further insights intoGPR179: expression, localization, and associated pathogenic mechanisms leading tocomplete congenital stationary night blindness. Invest Ophthalmol Vis Sci. 2013 Dec 9;54(13):8041-50. Errera MH, Girmens JF, Ayello-Scheer S, Nourry H, Warnet JM, Sahel JA, Barale PO.Correlation between aqueous flare and chorioretinal neovascularization in age-related macular degeneration following intravitreal bevacizumab injections.Fr Ophtalmol.2013 Oct 24. Sennlaub F, Auvynet C, Calippe B, Lavalette S, Poupel L, Hu SJ, Dominguez E, Camelo S, Levy O, Guyon E, Saederup N, Charo IF, Rooijen NV, Nandrot E, Bourges JL, Behar-Cohen F, Sahel JA, Guillonneau X, Raoul W, Combadiere C.CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice.EMBO Mol Med. 2013 Nov;5(11):1775-93. Bendali A, Lorach H, Djilas M, Marre O, Bensoman R, Rousseau L, Lissorgues G, Scorsone E, Bergonzo P, Garrido JA, Sahel JA, Picaud S.[Restoring vision in blind patients following photoreceptor degeneration: clinical results and future challenges].Biol Aujourdhui. 2013;207(2):123-32. Roska B, Busskamp V, Sahel JA, Picaud S. [Retinitis pigmentosa: eye sight restoration by optogenetic therapy].Biol Aujourdhui. 2013;207(2):109-21. Arnault E, Barrau C, Nanteau C, Gondouin P, Bigot K, Viénot F, Gutman E, Fontaine V, Villette T, Cohen-Tannoudji D, Sahel JA, Picaud S. Phototoxic action spectrum on a retinal pigment epithelium model of age-related macular degeneration exposed to sunlight normalized conditions. PLoS One. 2013 Aug 23;8(8):e71398. Audo I, Bujakowska K, Orhan E, El Shamieh S, Sennlaub F, Guillonneau X, Antonio A, Michiels C, Lancelot ME, Letexier M, Saraiva JP, Nguyen H, Luu TD, Léveillard T, Poch O, Dollfus H, Paques M, Goureau O, Mohand-Saïd S, Bhattacharya SS, Sahel JA, Zeitz C.The familial dementia gene revisited: a missense mutation revealed by whole exome sequencing identifies ITM2B as a candidate gene underlying a novel autosomal dominant retinal dystrophy in a large family.Hum Mol Genet.2013 Sep 10. [Epub ahead of print] Manes G, Meunier I, Avila-Fernández A, Banfi S, Le Meur G, Zanlonghi X, Corton M, Simonelli F, Brabet P, Labesse G, Audo I, Mohand-Said S, Zeitz C, Sahel JA, Weber M, Dollfus H, Dhaenens CM, Allorge D, De Baere E, Koenekoop RK, Kohl S, Cremers FP, Hollyfield JG, Sénéchal A, Hebrard M, Bocquet B, García CA, Hamel CP.Mutations in IMPG1 Cause Vitelliform Macular Dystrophies. Am J Hum Genet. 2013 Sep 5;93(3):571-8. 8 Delyfer MN, Aït-Ali N, Camara H, Clérin E, Korobelnik JF, Sahel JA, Léveillard T. Transcriptomic Analysis of Human Retinal Surgical Specimens Using jouRNAl. J Vis Exp. 2013 Aug 14;(78). Linderholm P, Guyomard JL, Djilas M, Salzmann J, Simonutti M, Sahel JA, Safran AB, Renaud P, Picaud S. Long-term in vivo impedance changes of subretinal microelectrodes implanted in dystrophic P23H rats. Int J Artif Organs.2013 Oct 3;36(9):612-9. Wolff B, Tick S, Sahel JA, Mauget-Faÿsse M, Shields CL, Shields JA.Diagnostic and Therapeutic Challenges.Retina. 2013 Jul 30. [Epub ahead of print] Sahel JA, Léveillard T, Picaud S, Dalkara D, Marazova K, Safran A, Paques M, Duebel J, Roska B, Mohand-Said S.Functional rescue of cone photoreceptors in retinitis pigmentosa.Graefes Arch Clin Exp Ophthalmol. 2013 Jul;251(7):1669-77. (REVIEW) Sahel JA, Roska B. Gene therapy for blindness. Ann Rev Neurosci 2013, Jul 8;36:467-88. (REVIEW) Doumanov JA, Zeitz C, Gimenez PD, Audo I, Krishna A, Alfano G, Diaz ML, Moskova-Doumanova V, Lancelot ME, Sahel JA, Nandrot EF, Bhattacharya SS.Disease-Causing Mutations in BEST1 Gene Are Associated with Altered Sorting of Bestrophin-1 Protein.Int J Mol Sci. 2013 Jul 22;14(7):15121-40. Lehmann M, Wolff B, Vasseur V, Martinet V, Manasseh N, Sahel JA, Mauget-Faÿsse M. Retinal and choroidal changes observed with 'En face' enhanced-depth imaging OCT in central serous chorioretinopathy.Br J Ophthalmol.2013 Sep;97(9):1181-6. Mateo-Montoya A, Wolff B, Sahel JA, Mauget-Faÿsse M.Outer retinal tubulations in serpinginous choroiditis.Br J Ophthalmol.2013 Jul 3. [Epub ahead of print] Steinberg JS, Auge J, Jaffe GJ, Fleckenstein M, Holz FG, Schmitz-Valckenberg S; GAP Study Group. Longitudinal analysis of reticular drusen associated with geographic atrophy in age-related macular degeneration.Invest Ophthalmol Vis Sci. 2013 Jun 10;54(6):4054-60. Tilleul J, Richard F, Puche N, Zerbib J, Leveziel N, Sahel JA, Cohen SY, Korobelnik JF, Feingold J, Munnich A, Kaplan J, Rozet JM, Souied EH. Genetic association study of mitochondrial polymorphisms in neovascular age-related macular degeneration.Mol Vis.2013 May 29;19:1132-40. The AMD Gene Consortium. Seven new loci associated with age-related macular degeneration. Nat Genetics2013 Apr;45(4):433- 9, 439e1-2. Wolff B, Basdekidou C, Vasseur V, Mauget-Faÿsse M, Sahel JA, Vignal C.Retinal inner nuclear layer microcystic changes in optic nerve atrophy: a novel spectral-domain OCT finding.Retina. 2013 Nov-Dec;33(10):2133-8. Lechauve C, Augustin S, Roussel D, Sahel JA, Corral-Debrinski M.Neuroglobin involvement in visual pathways through the optic nerve.Biochim Biophys Acta.2013 Sep;1834(9):1772-8. Gocho K, Sarda V, Falah S, Sahel JA, Sennlaub F, Benchaboune M, Ullern M, Paques M. Adaptive optics imaging of geographic atrophy.Invest Ophthalmol Vis Sci. 2013 May 1;54(5):3673-80. Bemelmans AP, Duqué S, Rivière C, Astord S, Desrosiers M, Marais T, Sahel JA, Voit T, Barkats M. A single intravenous AAV9 injection mediates bilateral gene transfer to the adult mouse retina.PLoS One. 2013 Apr 15;8(4):e61618. Errera MH, Liyanage SE, Elgohary M, Day AC, Wickham L, Patel PJ, Sahel JA, Paques M, Ezra E, Sullivan PM.Using spectral- domain optical coherence tomography imaging to identify the presence of retinal silicone oil emulsification after silicone oil tamponade.Retina. 2013 Sep;33(8):1567-73. Euvrard G, Genevois O, Rivals I, Massin P, Collet A, Sahel JA, Paques M.A semi-automated computer tool for the analysis of retinal vessel diameter dynamics.Comput Biol Med. 2013 Jun 1;43(5):513-23. Dorn JD, Ahuja AK, Caspi A, da Cruz L, Dagnelie G, Sahel JA, Greenberg RJ, McMahon MJ; gus II Study Group.The Detection of Motion by Blind Subjects With the Epiretinal 60-Electrode (Argus II) Retinal Prosthesis.JAMA Ophthalmol. 2013 Feb;131(2):183-9. 9 Niskopoulou M, Balaskas K, Leung I, Sallo FB, Clemons TE, Bird AC, Peto T; MacTel Study group.Is indocyanine green angiography useful for the diagnosis of macular telangiectasia type 2?Br J Ophthalmol. 2013 Jul;97(7):946-8. Fritsche LG, Chen W, Schu M, Yaspan BL, Yu Y, Thorleifsson G, Zack DJ, Arakawa S, Cipriani V, Ripke S, Igo RP Jr, Buitendijk GH, Sim X, Weeks DE, Guymer RH, Merriam JE, Francis PJ, Hannum G, Agarwal A, Armbrecht AM, Audo I, Aung T, Barile GR, Benchaboune M, Bird AC, Bishop PN, Branham KE, Brooks M, Brucker AJ, Cade WH, Cain MS, Campochiaro PA, Chan CC, Cheng CY, Chew EY, Chin KA, Chowers I, Clayton DG, Cojocaru R, Conley YP, Cornes BK, Daly MJ, Dhillon B, Edwards AO, Evangelou E, Fagerness J, Ferreyra HA, Friedman JS, Geirsdottir A, George RJ, Gieger C, Gupta N, Hagstrom SA, Harding SP, Haritoglou C, Heckenlively JR, Holz FG, Hughes G, Ioannidis JP, Ishibashi T, Joseph P, Jun G, Kamatani Y, Katsanis N, N Keilhauer C, Khan JC, Kim IK, Kiyohara Y, Klein BE, Klein R, Kovach JL, Kozak I, Lee CJ, Lee KE, Lichtner P, Lotery AJ, Meitinger T, Mitchell P, Mohand-Saïd S, Moore AT, Morgan DJ, Morrison MA, Myers CE, Naj AC, Nakamura Y, Okada Y, Orlin A, Ortube MC, Othman MI, Pappas C, Park KH, Pauer GJ, Peachey NS, Poch O, Priya RR, Reynolds R, Richardson AJ, Ripp R, Rudolph G, Ryu E, Sahel JA, Schaumberg DA, Scholl HP, Schwartz SG, Scott WK, Shahid H, Sigurdsson H, Silvestri G, Sivakumaran TA, Smith RT, Sobrin L, Souied EH, Stambolian DE, Stefansson H, Sturgill-Short GM, Takahashi A, Tosakulwong N, Truitt BJ, Tsironi EE, Uitterlinden AG, van Duijn CM, Vijaya L, Vingerling JR, Vithana EN, Webster AR, Wichmann HE, Winkler TW, Wong TY, Wright AF, Zelenika D, Zhang M, Zhao L, Zhang K, Klein ML, Hageman GS, Lathrop GM, Stefansson K, Allikmets R, Baird PN, Gorin MB, Wang JJ, Klaver CC, Seddon JM, Pericak-Vance MA, Iyengar SK, Yates JR, Swaroop A, Weber BH, Kubo M, Deangelis MM, Léveillard T, Thorsteinsdottir U, Haines JL, Farrer LA, Heid IM, Abecasis GR; AMD Gene Consortium.Seven new loci associated with age-related macular degeneration.Nat Genet. 2013 Apr;45(4):433-9, 439e1-2. da Cruz L, Coley BF, Dorn J, Merlini F, Filley E, Christopher P, Chen FK, Wuyyuru V, Sahel J, Stanga P, Humayun M, Greenberg RJ, Dagnelie G; for the Argus II Study Group. The Argus II epiretinal prosthesis system allows letter and word reading and long- term function in patients with profound vision loss. Br J Ophthalmol.2013 May;97(5):632-6. Rosolen SG, Neveux N, Sahel JA, Picaud S, Froger N. Evaluation of the taurine concentrations in dog plasma and aqueous humour: a pilot study. Adv Exp Med Biol. 2013;775:145-54. Froger N, Jammoul F, Gaucher D, Cadetti L, Lorach H, Degardin J, Pain D, Dubus E, Forster V, Ivkovic I, Simonutti M, Sahel JA, Picaud S. Taurine is a crucial factor to preserve retinal ganglion cell survival. Adv Exp Med Biol. 2013;775:69-83. Bocquet B, Lacroux A, Surget MO, Baudoin C, Marquette V, Manes G, Hebrard M, Sénéchal A, Delettre C, Roux AF, Claustres M, Dhaenens CM, Rozet JM, Perrault I, Bonnefont JP, Kaplan J, Dollfus H, Amati-Bonneau P, Bonneau D, Reynier P, Audo I, Zeitz C, Sahel JA, Paquis-Flucklinger V, Calvas P, Arveiler B, Kohl S, Wissinger B, Blanchet C, Meunier I, Hamel CP. Relative Frequencies of Inherited Retinal Dystrophies and Optic Neuropathies in Southern France: Assessment of 21-year Data Management. Ophthalmic Epidemiol. 2013;20(1):13-25. Errera MH, Goldschmidt P, Batellier L, Degorge S, Héron E, Laroche L, Sahel JA, Westcott M, Chaumeil C. Findings in detection of herpesviridae by polymerase chain reaction and intraocular antibody production in a case series of anterior uveitis. Ocul Immunol Inflamm. 2013 Feb;21(1):46-53. Wolff B, Sahel JA, Mateo-Montoya A, Mauget-Faÿsse M, Baillif S, Le Mer Y. [Intravitreal ranibizumab for management of choroidal neovascularization secondary to angioid streaks: A case report.] J Fr Ophtalmol.2013 Jan;36(1):e5-9. Zeitz C, Jacobson SG, Hamel CP, Bujakowska K, Neuillé M, Orhan E, Zanlonghi X, Lancelot ME, Michiels C, Schwartz SB, Bocquet B; Congenital Stationary Night Blindness Consortium, Antonio A, Audier C, Letexier M, Saraiva JP, Luu TD, Sennlaub F, Nguyen H, Poch O, Dollfus H, Lecompte O, Kohl S, Sahel JA, Bhattacharya SS, Audo I. Whole-Exome Sequencing Identifies LRIT3 Mutations as a Cause of Autosomal-Recessive Complete Congenital Stationary Night Blindness. Am J Hum Genet. 2013 Jan 10;92(1):67-75. Liang F, Audo I, Sahel JA, Paques M. Retinal degeneration in mucopolysaccharidose type II. Graefes Arch Clin Exp Ophthalmol.2013 Jul;251(7):1871-2 2012 Lauritzen TZ, Harris J, Mohand-Said S, Sahel JA, Dorn JD, McClure K and Greenberg RJ (2012) Reading visual braille with a retinal prosthesis. Front. Neurosci. 6:168. doi: 10.3389/fnins.2012.00168 Lorach H, Marre O, Sahel JA, Benosman R, Picaud S. Neural stimulation for visual rehabilitation: Advances and challenges. J Physiol Paris. 2012 Nov 10. 10