University of Groningen Anemia and erythropoietin in cardiovascular disease Kleijn, Lennaert IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2014 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Kleijn, L. (2014). Anemia and erythropoietin in cardiovascular disease. s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license. More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne- amendment. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 17-03-2023 Anemia and Erythropoietin in Cardiovascular Disease Lennaert Kleijn Financial support by Amgen bv, Boehringer Ingelheim bv, Bayer Healthcare Pharmaceuticals bv, Graduate School of Medical Sciences, Servier Nederland Farma bv, Rijksuniversiteit Groningen, St. Jude Medical Nederland bv, Chipsoft bv, Roche Nederland bv, Vifor Pharma bv for the publication of this thesis is gratefully acknowledged. Copyright 2013 Lennaert Kleijn All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means without written permission of the author and, when appropri- ate, the publisher holding the copyrights of the published articles. ISBN: 978-90-367-6713-2 ISBN: 978-90-367-6714-9 (e-pub) Cover design and layout by Claudia Gonzalez Arevalo [email protected] http://cmgonzalezarevalo.wix.com/layout Printed by Grafimedia Facilitair bedrijf RUG Anemia and erythropoietin in cardiovascular disease Proefschrift ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen op gezag van de rector magnificus, prof. dr. E. Sterken en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op maandag 3 februari 2014 om 14:30 uur door Lennaert Kleijn geboren op 9 oktober 1985 te Nagele Promotor: Prof. dr. D.J. van Veldhuisen Copromotores: Dr. P. Van der Meer Dr. B.D. Westenbrink Beoordelingscommissie: Prof. dr. C.A.J.M. Gaillard Prof. dr. D. Swinkels Prof. dr. H.L. Hillege Paranimfen: W.T. Ruifrok F. Imhann Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged. Table of contents Chapter 1 Introduction and aim of the thesis Part 1 I Anemia in cardiovascular disease Chapter 2 Anemia and its association with hemodynamics in a broad spectrum of cardiovascular patients Under revision Chapter 3 Inflammation and anemia in a broad spectrum of patients with heart failure Heart. 2012 Aug;98(16):1237-41 Chapter 4 Impact of postoperative anemia on cardiovascular outcome after Coronary artery bypass graft surgery; insights from the IMAGINE trial Heart. 2011 Oct;97(19):1590-6 Chapter 5 Impaired erythropoiesis after coronary artery bypass grafting is associated with an increased inflammatory response Submitted Part 2 I Erythropoietin in cardiovascular disease Chapter 6 Should erythropoietin treatment in chronic heart failure be hemoglobin targeted? Eur J Heart Fail. 2010 Mar;12(3):215-6 Chapter 7 Long term effects of epoetin alfa in patients with ST- elevation myocardial infarction Cardiovasc Drugs Ther. 2013 Oct;27(5):433-9 Chapter 8 Erythropoietin and heart failure: the end of a promise? Eur J Heart Fail. 2013 May;15(5):479-81 Chaper 9 Summary, conclusions and future directions Appendices Nederlandse samenvatting Dankwoord Bibliography Curriculum Vitae Introduction and aim 1 of the thesis Chapter