IFMBE Proceedings Volume 27 Series Editor: R. Magjarevic The International Federation for Medical and Biological Engineering, IFMBE, is a federation of national and transnational organizations representing internationally the interests of medical and biological engineering and sciences. The IFMBE is a non-profit organization fostering the creation, dis- semination and application of medical and biological engineering knowledge and the management of technology for improved health and quality of life. Its activities include participation in the formulation of public policy and the dissemination of information through publications and forums. Within the field of medical, clinical, and biological engineering, IFMBE’s aims are to encourage research and the application of knowledge, and to disseminate information and promote collaboration. The objectives of the IFMBE are scientific, technological, literary, and educational. The IFMBE is a WHO accredited NGO covering the full range of biomedical and clinical engineering, healthcare, healthcare technology and man- agement. It is representing through its 58 member societies some 120.000 professionals involved in the various issues of improved health and health care delivery. IFMBE Officers President: Makoto Kikuchi, Vice-President: Herbert Voigt, Former-President: Joachim H. Nagel Treasurer: Shankar M. Krishnan, Secretary-General: Ratko Magjarevic http://www.ifmbe.org Previous Editions: IFMBE Proceedings ICDBME 2010, “The Third International Conference on the Development of Biomedical Engineering in Vietnam”, Vol. 27, 2010, Ho Chi Minh City, Vietnam, CD IFMBE Proceedings MEDITECH 2009, “International Conference on Advancements of Medicine and Health Care through Technology”, Vol. 26, 2009, Cluj-Napoca, Romania, CD IFMBE Proceedings WC 2009, “World Congress on Medical Physics and Biomedical Engineering”, Vol. 25, 2009, Munich, Germany, CD IFMBE Proceedings SBEC 2009, “25th Southern Biomedical Engineering Conference 2009”, Vol. 24, 2009, Miami, FL, USA, CD IFMBE Proceedings ICBME 2008, “13th International Conference on Biomedical Engineering” Vol. 23, 2008, Singapore, CD IFMBE Proceedings ECIFMBE 2008 “4th European Conference of the International Federation for Medical and Biological Engineering”, Vol. 22, 2008, Antwerp, Belgium, CD IFMBE Proceedings BIOMED 2008 “4th Kuala Lumpur International Conference on Biomedical Engineering”, Vol. 21, 2008, Kuala Lumpur, Malaysia, CD IFMBE Proceedings NBC 2008 “14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics”, Vol. 20, 2008, Riga, Latvia, CD IFMBE Proceedings APCMBE 2008 “7th Asian-Pacific Conference on Medical and Biological Engineering”, Vol. 19, 2008, Beijing, China, CD IFMBE Proceedings CLAIB 2007 “IV Latin American Congress on Biomedical Engineering 2007, Bioengineering Solution for Latin America Health”, Vol. 18, 2007, Margarita Island, Venezuela, CD IFMBE Proceedings ICEBI 2007 “13th International Conference on Electrical Bioimpedance and the 8th Conference on Electri- cal Impedance Tomography”, Vol. 17, 2007, Graz, Austria, CD IFMBE Proceedings MEDICON 2007 “11th Mediterranean Conference on Medical and Biological Engineering and Computing 2007”, Vol. 16, 2007, Ljubljana, Slovenia, CD IFMBE Proceedings BIOMED 2006 “Kuala Lumpur International Conference on Biomedical Engineering”, Vol. 15, 2004, Kuala Lumpur, Malaysia, CD IFMBE Proceedings WC 2006 “World Congress on Medical Physics and Biomedical Engineering”, Vol. 14, 2006, Seoul, Korea, DVD IFMBE Proceedings BSN 2007 “4th International Workshop on Wearable and Implantable Body Sensor Networks”, Vol. 13, 2006, Aachen, Germany IFMBE Proceedings ICBMEC 2005 “The 12th International Conference on Biomedical Engineering”, Vol. 12, 2005, Singapore, CD IFMBE Proceedings Vol. 27 Vo Van Toi • Truong Quang Dang Khoa (Eds.) The Third International Conference on the Development of Biomedical Engineering in Vietnam BME2010 11–14 January, 2010 Ho Chi Minh City, Vietnam 123 Editors Vo Van Toi Chair of Biomedical Engineering Department International University - Vietnam National Universities at HCM Quarter 6, Linh Trung, Thu Duc Dist. Ho Chi Minh City, Vietnam E-mail: About IFMBE The International Federation for Medical and Biological Engineering (IFMBE) was established in 1959 to provide medical and biological engineering with a vehicle for international collaboration in research and practice of the profession. The Fed- eration has a long history of encouraging and promoting international cooperation and collaboration in the use of science and engineering for improving health and quality of life. The IFMBE is an organization with membership of national and transnational societies and an International Academy. At present there are 52 national members and 5 transnational members representing a total membership in excess of 120000 worldwide. An observer category is provided to groups or organizations considering formal affiliation. Personal membership is possible for individuals living in countries without a member society The International Academy includes individuals who have been recognized by the IFMBE for their outstanding contributions to biomedical engineering. Objectives The objectives of the International Federation for Medical and Biological Engineering are scientific, technological, literary, and educational. Within the field of medical, clinical and biological engineering it’s aims are to encourage research and the application of knowledge, and to disseminate information and promote collaboration. In pursuit of these aims the Federation engages in the following activities: sponsorship of national and international meet- ings, publication of official journals, cooperation with other societies and organizations, appointment of commissions on special problems, awarding of prizes and distinctions, establishment of professional standards and ethics within the field, as well as other activities which in the opinion of the General Assembly or the Administrative Council would further the cause of medical, clinical or biological engineering. It promotes the formation of regional, national, international or specialized societies, groups or boards, the coordination of bibliographic or informational services and the improvement of standards in terminology, equipment, methods and safety practices, and the delivery of health care. The Federation works to promote improved communication and understanding in the world community of engineering, medicine and biology. Activities Publications of IFMBE include: the journal Medical and Biological Engineering and Computing, the electronic magazine IFMBE News, and the Book Series on Biomedical Engineering. In cooperation with its international and regional confer- ences, IFMBE also publishes the IFMBE Proceedings Series. All publications of the IFMBE are published by Springer Ver- lag. The Federation has two divisions: Clinical Engineering and Health Care Technology Assessment. Every three years the IFMBE holds a World Congress on Medical Physics and Biomedical Engineering, organized in co- operation with the IOMP and the IUPESM. In addition, annual, milestone and regional conferences are organized in different regions of the world, such as Asia Pacific, Europe, the Nordic-Baltic and Mediterranean regions, Africa and Latin America. The administrative council of the IFMBE meets once a year and is the steering body for the IFMBE: The council is sub- ject to the rulings of the General Assembly, which meets every three years. Information on the activities of the IFMBE can be found on the web site at: http://www.ifmbe.org. Preface Vietnam is a rapidly developing, socially dynamic country, where interest in biomedical engineering activities has grown considerably in recent years. The leadership of the Vietnamese government, and of research and educational institutions, are well aware of the importance of this field for the development of the country and have instituted policies to promote its development. The political, economic and social environment within the country offers unique opportunities for the international community and this conference was intended to provide a vehicle for the sharing of experiences; development of support and collaboration networks for research; and exchange of ideas on how to improve the educational and entrepreneurial environment to better address the urgent needs of Vietnam. In January 2004, under the sponsorship of the U.S. National Science Foundation, a U.S. delegation that consisted of Biomedical Engineering professors from different universities in the United States, visited several universities and research institutions in Vietnam to assess the state of development of this field. This delegation proposed a five year plan that was enthusiastically embraced by the international scientific communities to actively develop collaborations with Vietnam. Within this framework, in July 2005, the First International Conference on the Development of Biomedical Engineering in Vietnam was held in Ho Chi Minh City. From that conference a Consortium of Vietnam-International Universities was created to advise and assist the development of Biomedical Engineering in Vietnamese universities. In July 2007, the Second International Conference on the Development of Biomedical Engineering in Vietnam was held in Hanoi. During this event the Vietnamese Association of Biomedical Science and Engineering was endorsed by the Asia- Pacific International Molecular Biology Network (AIMBN), Biomedical Engineering Society Singapore (BESS), International Federation for Medical and Biological Engineering (IFMBE), Société Française de Génie Biologique et Médical (SFGBM) and IFMBE Asia-Pacific Working Group. In March 2009, International University (IU), a member of Vietnam National Universities – Ho Chi Minh City (VNU-HCM), one of the two most famous university networks in Vietnam established its Biomedical Engineering Department and the first accredited Biomedical Engineering degree in Vietnam (code: 52.42.02.04). IU is the first public university in Vietnam that teaches all courses in English and was created as a new model to modernize the higher education in Vietnam. The Third International Conference on the Development of Biomedical Engineering in Vietnam was organized on January 11–14, 2010, by IU in Ho Chi Minh City, Vietnam and had the theme of: “New frontiers in Biomedical Engineering”. It reflected the steady growth of the activities in this field in Vietnam, and featured the contributions of researchers of 21 countries, including: Australia, Belgium, Canada, Denmark, France, India, Japan, Korea, Malaysia, New Zealand, Philippines, Poland, Russia, Singapore, Spain, Switzerland, Taiwan, Thailand, United Kingdom, the United States and Vietnam. The main keynote speaker was Dr. John C. Gore, University Professor of Radiology and Radiological Sciences, Biomedical Engineering, and Physics, and Director of Vanderbilt University Institute of Imaging Science (U.S.). The special topic keynote speakers were Dr. Robert E. Burrell, Professor and Canada Research Chair in Nano-structured Biomaterials (Canada); Dr. K. Kirk Shung, Professor and Director of National Institutes of Health Resource on Medical Ultrasonic Transducer Technology of University of Southern California, (U.S.); and Dr. Regis B. Kelly, Professor and Director of California Institute for Quantitative Biosciences (QB3) (U.S.). Besides the invited, oral and poster presentations there were tutorial lectures to educate junior researchers in different subfields of Biomedical Engineering. This volume summarizes those presentations and was provided as an education foundation and scientific reference. The Conference constituted a kick- off event to celebrate the 15 Anniversary of the establishment of VNU-HCM and also hosted the Clinical Engineering Workshop of the IFMBE Asia Pacific Working Group. VIII Preface The editors would like to thank the leadership of VNU-HCM and IU, and the staff of Biomedical Engineering Department and of difference offices of IU for their valuable support for the conference and their assistance in the editing and publication of this volume. Vo Van Toi and Truong Quang Dang Khoa Biomedical Engineering Department International University of the Vietnam National Universities – Ho Chi Minh www.hcmiu.edu.vn/bme Table of Contents Keynote Speakers Challenges and Opportunities of Ultra-High Field MRI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 A.N. Dula, E.B. Welch, J.L. Creasy, J.C. Gatenby, E.A. Stringer, L.M. Chen, A.W. Anderson, M.J. Avison, J.C. Gore Nanocrystalline Silver: Novel Structure and Activity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Robert E. Burrell, Patricia Nadworny Ultrasound: Past, Present and Future . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 K. Kirk Shung Bioengineering in Vietnam . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 Regis B. Kelly Invited Speakers Detection and Treatment of Diseases Using Light . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 W. Pham Magnetic Resonance Imaging of Schizophrenia and Alzheimer’s Disease . . . . . . . . . . . . . . . . . . . . . 23 A.W. Anderson, X. Hong, L.R. Arlinghaus, M. Tumuklu, Thornton-Wells, R.E. Hoffman, S. Park, H.Y. Meltzer Current Development of Neuroimaging Using PET Techniques . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 A.L. Brownell Peanut Agglutinin-Immobilized Fluorescent Nanospheres with Surface Poly(N-vinylacetamide) Chains as a Novel Colonoscopic Imaging Agent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 S. Sakuma, K. Hiwatari, T. Yano, K. Iwata, Y. Masaoka, M. Kataoka, H. Tachikawa, Y. Shoji, R. Kimura, K. Nakamura, H. Ma, Z. Yang, L. Tang, R.M. Hoffman, S. Yamashita Techniques for the Incorporation of Fluorine-18 and Carbon-11 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 Nickels, W. Pham Modeling Dynamic Model Identification of PAM-Based Rehabilitation Robot Using Neural MIMO NARX Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 Ho Pham Huy Anh, Le Tan Loi Simulation of the Gait of a Patient Specific Model of Post Polio Residual Paralysis (PPRP): Effect of the Orthosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44 T.T. Dao, P. Pouletaut, F. Marin, P. Aufaure, F. Charleux, M.C. Ho Ba Tho Mechanical Behavior of Muscles during Flexion and Extension of Lower Limb on Variable Age Group by Using BRG.LifeMod . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48 Nitin Sahai, Ravi P. Tewari, Lokesh Singh X Table of Contents Biomechanics of Index Finger during Mouse Click . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 P. Chivapornthip, E.L.J. Bohez, S. Nanthavanij, K. Sitthiseripratip, E. Lorprayoon Numerical Study of Deformation-Induced Fluid Flows in Osteonal Matrix . . . . . . . . . . . . . . . . . . . 55 V.-H. Nguyen, T. Lemaire, S. Naili Evaluation Spatial-temporal and Pressure Parameters of Normal Cats at Walk, Using a Pressure Walkway . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 T. LeQuang, P. Maitre, A. Colin, E. Viguier Gait Analysis for Sound Dogs at a Walk by Using a Pressure Walkway . . . . . . . . . . . . . . . . . . . . . . 62 T. LeQuang, P. Maitre, A. Colin, T. Roger, E. Viguier Robust Design with Time-Oriented Responses for Regenerative Medicine Industry . . . . . . . . . . 67 N.K.V. Truong, S.M. Shin, Y.S. Choi, S.H. Jeong, B.R. Cho Cerebral Palsy Classification Using Heuristics and Belief Decision Tree: A Preliminary Study. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71 T.T. Dao, F. Marin, F. Mégrot, M.C. Ho Ba Tho Test for Determinism and Nonlinearity in Near Infrared Spectroscopy Data . . . . . . . . . . . . . . . . . 75 N.T. Dzung Multifractality in NIRS Data of Brain Activity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 80 N.T. Dzung Instrumentation Design, Fabrication and Analysis of Silicon Microneedles for Transdermal Drug Delivery Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84 D.W. Bodhale, A. Nisar, N. Afzulpurkar Heat-Stress Relationships of Rat Cardiac Trabeculae Determined Using a Micromechanocalorimeter . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 90 J.-C. Han, A.J. Taberner, P.M.F. Nielsen, R.S. Kirton, D.S. Loiselle About the Operating Principles of System DDFAO “(Dépistage et Diagnostique Fonctionnel Assisté Par Ordinateur)” . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 94 Huynh Luong Nghia, Nguyen Van Tiep A Design of Renal Dataflow Control and Patient Record Management System for Renal Department Environment in Vietnam . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 98 Hai D. Vu, Thuan D. Nguyen, Ngoc P. Pham, Huy Q. Hoang, Thanh V. Pham Anisotropy of Longitudinal Wave Velocity in Spherically Shaped Bovine Cortical Bone . . . . . . 102 K. Yamamoto, T. Nakatsuji, M. Indo, T. Yanagitani, M. Matsukawa, K. Yamazaki Calculating the Dosimetry Distribution of Leksell Gamma Knife in Phantom Zubal Head by Using MCNP5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 106 Dang Truong Ka My, Dang Nguyen Phuong, Truong Thi Hong Loan, Mai Van Nhon A Program for Locating Possible Breast Masses on Mammograms . . . . . . . . . . . . . . . . . . . . . . . . . . . 110 Viet Dzung Nguyen, Duc Thuan Nguyen, Tien Dzung Nguyen, Thom Thao Nguyen Thi, Duc Hoa Tran Table of Contents XI Retrospective Study of Biomechanical Factors Influencing Early Clinical Results of the Munting Stemless Hip Prosthesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 114 F. Boucher, P. Pouletaut, E. Munting, M.C. Ho Ba Tho Integrated Approaches for Personalised Cranio-Maxillofacial Implant Design and Manufacturing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119 L.C. Hieu, E. Bohez, J.V. Sloten, L.T. Hung, L. Khanh, N. Zlatov, P.D. Trung Current Medical Product Development for Diagnosis, Surgical Planning and Treatment in the Areas of Neurosurgery, Orthopeadic and Dental-Cranio-Maxillofacial Surgery in Vietnam . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123 L.C. Hieu, L.H. Quoc, V.V. Thanh, T.D. Nguyen, P.V. An, L.T. Hung, L. Khanh Glass Nanopipette: Fabrication and Application for Studying Living Cells . . . . . . . . . . . . . . . . . . . 127 Duong Chi Dung, Huynh Luong Nghia, V.P. Veiko, A.O. Golubok, E.B. Yakovlev Resolution Study of Ultrasound Reflections in Bovine Vertebral Bones In-Vitro . . . . . . . . . . . . . 130 L.H. Le, C. Zhang, E. Lou Light-Emitting Diodes (LEDs): An Artificial Lighting Source for Biological Studies . . . . . . . . . . 134 Duong Tan Nhut, Nguyen Ba Nam A Novel Electronic Cervical Range of Motion Measurement System . . . . . . . . . . . . . . . . . . . . . . . . . 140 E. Lian, J. Hachadorian, Ngo Thanh Hoan, Vo Van Toi Measurement of the Range of Neck Motion: A Comparative Study . . . . . . . . . . . . . . . . . . . . . . . . . . 144 J. Hachadorian, A. Lugo, E. Lian, Truong Quang Dang Khoa, Vo Van Toi Molecular/Cell Extract an Irregular Structure of an Echinocytes Using Morphological Operations . . . . . . . . . . . 148 Hoang Manh Ha, Thai Thanh Nga Study on Artificial Scaffold from Cancellous Bone . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 152 To Minh Quan, Thai Tu Thanh, Phan Kim Ngoc, Tran Le Bao Ha Report Case: Cultured Keratinocyte Autograft on Collagen from Amniotic Membrane for Treatment the Injured Human Skin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155 Tran Le Bao Ha, Huynh Minh Tuan, Tran Thi Thanh Thuy, Tran Cong Toai, Hoang Nghia Son Doxorubicin Delivery by Copolymeric Nanoparticle for Treatment of Breast Cancer . . . . . . . . . 159 N.V. Cuong, J.L. Jiang, M.F. Hsiesh Regeneration of Pancreatic β Cells of Type 1 Diabetic Mouse by Stem Cell Transplatation . . 163 Pham Van Phuc, Pham Le Buu Truc, Duong Thanh Thuy, Truong Hai Nhung, Doan Chinh Chung, Nguyen Khac Toan, Ma Kien Phuc, Phan Kim Ngoc Results of Curing Some Diseases by Stem Cell Transplantation at Stem Cell R&D Laboratory . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167 Phan Kim Ngoc, Pham Van Phuc Regulations of Cell Division from Streptomyces That May Play an Important Role in Drug Resistance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171 Nguyen H.K. Tu