Volume Contents Volume 199, Number | January 2003 Commentaries Stages on the way to breast cancer JJ Going The yeast two-hybrid system for identifying protein-protein interactions PJ Coates and PA Hall Review Article Protective role of endothelial nitric oxide synthase EWJA Albrecht, CA Stegeman, P Heeringa, RH Henning and H van Goor Original Papers The profliferation marker pKi-67 organizes the nucleolus during the cell cycle depending on Ran and cyclin B MHH Schmidt, R Broll, HP Bruch, O Bogler and M Duchrow Chemokine expression in IBD Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn’s disease C Banks, A Bateman, R Payne, P Johnson and N Sheron Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric Carcinomas R Almeida, E Silva, F Santos-Silva, DG Silberg, J Wang, C De Bolds and L David Uroplakin gene expression in normal human tissues and locally advanced bladder cancer J Olsburgh, P Harnden, R Weeks, B Smith, A Joyce, G Hall, R Poulsom, P Selby and J Southgate .................... kc ccceceeeceeceecceecsersseceeeceseeceeeeeensseseseeseeesseesseed 41 Frequent genetic alterations in flat urothelial hyperplasias and concomitant papillary bladder cancer as detected by CGH, LOH and FISH analyses EC Obermann, K Junker, R Stoehr, W Dietmaier, D Zaak, J Schubert, F Hofstaedter, R Knuechel and A Hartmann Cribriform-morular variant of papillary thyroid carcinoma: a pathological and molecular genetic study with evidence of frequent somatic mutations in exon 3 of the §-catenin gene B Xu, K Yoshimoto, A Miyauchi, S Kuma, N Mizusawa, M Hirokawa and T Sano Nuclear accumulation of {'-catenin protein in Wilms’ tumours R Koesters, F Niggli, M von Knebel Doeberitz and I oe sau e ndelnsacihceeaiaivnak tains ta sabeibicbaacielichiote desnicdetoedins daca ddeicamesndd Gieatalspan diane tnsit ci acnbkishatiaataisanteiidhaoimicabaien 68 Killer cell immunoglobulin-like receptor expression delineates in situ Sézary syndrome lymphocytes J Wechsler, M Bagot, M Nikolova, S Parolini, N Martin-Garcia, L Boumsell, A Moretta and A Bensussan Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours R Lai, GZ Rassidakis, LJ Medeiros, V Leventaki, M Keating and TJ McDonnell Expression of Mcl-1 in mantle cel lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression JD Khoury, LJ Medeiros, GZ Rassidakis, TJ McDonnell, LV Abruzzo and R Lai ..............cccccccccceeseerseeeeeeeeees 90 Differential expression of CCL19 by DC-Lamp* mature dendritic cells in human lymph node versus chronically inflamed skin F Katou, H Ohtani, T Nakayama, H Nagura, O Yoshie and K Motegi ...............0..ccccccceccceeeseceesecessceessrenseceeesseeseeeeereeee’ 98 Psoriatic lesional skin exhibits an aberrant expression pattern of interferon regulatory factor-2 (IRF-2) L van der Fits, LI van der Wel, JD Laman, EP Prens and MCM Verschuren Expression of lymphotoxin-beta (LT-() in chronic inflammatory conditions S Agyekum, A Church, M Sohail, T Krausz, S Van Noorden, J Polak and J Cohen Type 2 nitric oxide synthase and protein nitration in chronic lung infection N Hopkins, E Cadogen, S Giles, J Bannigan I I oss i Socata sca tlligsetaceimemioumneaanioing gaint steer inuiladnsidaiasiachoma iuaeianins Wea semeaatadicstioenawaceiban inteasedaiwlbieniacaanisiacdaisadacaaed 122 Letters to the Editor Announcements Volume Contents Volume 199, Number | January 2003 Commentaries Stages on the way to breast cancer JJ Going The yeast two-hybrid system for identifying protein-protein interactions PJ Coates and PA Hall Review Article Protective role of endothelial nitric oxide synthase EWJA Albrecht, CA Stegeman, P Heeringa, RH Henning and H van Goor Original Papers The profliferation marker pKi-67 organizes the nucleolus during the cell cycle depending on Ran and cyclin B MHH Schmidt, R Broll, HP Bruch, O Bogler and M Duchrow Chemokine expression in IBD Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn’s disease C Banks, A Bateman, R Payne, P Johnson and N Sheron Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric Carcinomas R Almeida, E Silva, F Santos-Silva, DG Silberg, J Wang, C De Bolds and L David Uroplakin gene expression in normal human tissues and locally advanced bladder cancer J Olsburgh, P Harnden, R Weeks, B Smith, A Joyce, G Hall, R Poulsom, P Selby and J Southgate .................... kc ccceceeeceeceecceecsersseceeeceseeceeeeeensseseseeseeesseesseed 41 Frequent genetic alterations in flat urothelial hyperplasias and concomitant papillary bladder cancer as detected by CGH, LOH and FISH analyses EC Obermann, K Junker, R Stoehr, W Dietmaier, D Zaak, J Schubert, F Hofstaedter, R Knuechel and A Hartmann Cribriform-morular variant of papillary thyroid carcinoma: a pathological and molecular genetic study with evidence of frequent somatic mutations in exon 3 of the §-catenin gene B Xu, K Yoshimoto, A Miyauchi, S Kuma, N Mizusawa, M Hirokawa and T Sano Nuclear accumulation of {'-catenin protein in Wilms’ tumours R Koesters, F Niggli, M von Knebel Doeberitz and I oe sau e ndelnsacihceeaiaivnak tains ta sabeibicbaacielichiote desnicdetoedins daca ddeicamesndd Gieatalspan diane tnsit ci acnbkishatiaataisanteiidhaoimicabaien 68 Killer cell immunoglobulin-like receptor expression delineates in situ Sézary syndrome lymphocytes J Wechsler, M Bagot, M Nikolova, S Parolini, N Martin-Garcia, L Boumsell, A Moretta and A Bensussan Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours R Lai, GZ Rassidakis, LJ Medeiros, V Leventaki, M Keating and TJ McDonnell Expression of Mcl-1 in mantle cel lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression JD Khoury, LJ Medeiros, GZ Rassidakis, TJ McDonnell, LV Abruzzo and R Lai ..............cccccccccceeseerseeeeeeeeees 90 Differential expression of CCL19 by DC-Lamp* mature dendritic cells in human lymph node versus chronically inflamed skin F Katou, H Ohtani, T Nakayama, H Nagura, O Yoshie and K Motegi ...............0..ccccccceccceeeseceesecessceessrenseceeesseeseeeeereeee’ 98 Psoriatic lesional skin exhibits an aberrant expression pattern of interferon regulatory factor-2 (IRF-2) L van der Fits, LI van der Wel, JD Laman, EP Prens and MCM Verschuren Expression of lymphotoxin-beta (LT-() in chronic inflammatory conditions S Agyekum, A Church, M Sohail, T Krausz, S Van Noorden, J Polak and J Cohen Type 2 nitric oxide synthase and protein nitration in chronic lung infection N Hopkins, E Cadogen, S Giles, J Bannigan I I oss i Socata sca tlligsetaceimemioumneaanioing gaint steer inuiladnsidaiasiachoma iuaeianins Wea semeaatadicstioenawaceiban inteasedaiwlbieniacaanisiacdaisadacaaed 122 Letters to the Editor Announcements Volume Contents Volume 199, Number 2 February 2003 Commentary Colorectal tumorigenesis in carriers of the APC 11307K variant: lone gunman or conspiracy? O Sieber, L Lipton, K Heinimann and I Tomlinson Review Article Epstein-Barr virus-associated carcinomas: facts and fiction K Herrmann and G Niedobitek Original Papers The characterization of somatic APC mutations in colonic adenomas and carcinomas in Ashkenazi Jews with the APC 11307K variant using linkage disequilibrium NP Zauber, M Sabbath-Solitare, SP Marotta and DT Bishop Comparative genomic hybridization analysis of bilateral hyperplasia of usual type of the breast C Jones, S Merrett, VA Thomas, TH Barker and SR Lukhani Barrett’s adenocarcinomas resemble adenocarcinomas of the gastric cardia in terms of chromosomal copy number changes, but relate to squamous cell carcinomas of the distal oesophagus with respect to the presence of high-level amplifications MM Weiss, EJ Kuipers, MAJA Hermsen, NCT van Grieken, J Offerhaus, JPA Baak, SGM Meuwissen and GA Meijer Diverse p53 alterations in ulcerative colitis-associated low-grade dysplasia: full-length gene sequencing in microdissected single crypts T Yoshida, T Mikami, H Mitomi and I Okayasu Association of trypsin expression with tumour progression and matrilysin expression in human colorectal cancer H Yamamoto, S Iku, Y Adachi, A Imsumran, H Taniguchi, K Nosho, Y Min, S Horiuchi, M Yoshida, F Itoh and K Imai Significance of aberrant (cytoplasmic/nuclear) expression of beta-catenin in pancreatoblastoma Y Tanaka, K Kato, K Notohara, Y Nakatani, T Miyake, R Ijiri, S Nishimata, Y Ishida, H Kigasawa, Y Ohama, C Tsukayama, Y Kobayashi and H Horie Liver pathology and hepatocarcinogenesis in a long-term mouse model of erythropoietic protoporphyria L Libbrecht, L Meerman, F Kuipers, TR oskams, V Desmet and P Jansen High-throughput tissue microarray analysis of Gl-cyclin alterations in classical Hodgkin’s lymphoma indicated overexpression of cyclin El A Tzankov, A Zimpfer, A Lugli, J Krugmann, P Went, P Schraml, R Maurer, S Ascani, S Pileri, S Geley and S Dirnhofer Diversity in expression and prognostic significance of G1/S cyclins in human primary lung carcinomas Y Dobashi, S-X Jiang, M Shoji, S Morinaga and T Kameya Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with the TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts WR Duan, DS Garner, SD Williams, CL Funckes-Shippy, IS Spath and EAG Blomme Myocytes positive for in situ markers for DNA breaks in human hearts which are hypertrophic, but neither failed nor dilated: a manifestation of cardiac hypertrophy rather than failure M Koda, G Takemura, M Kanoh, K Hayakawa, Y Kawase, R Maruyama,Y Li, S Minatoguchi, T Fujiwara and H Fujiwara Mutations of mtDNA in renal cell tumours arising in end-stage renal disease A Nagy, M Wilhelm and G Kovacs Papillary carcinoma of the thyroid: evidence for a role for hepatocyte growth factor (HGF) in promoting tumour angiogenesis S Scarpino, FC d’Alena, A Di Napoli, F Ballarini, M Prat and LP Ruco Nuclear expression of Y-box-binding protein-1 correlates with P-glycoprotein and topoisomerase Il alpha expression, and with poor prognosis in synovial sarcoma Y Oda, Y Ohishi, T Saito, E Hinoshita, T Uchiumi, N Kinukawa, Y Iwamoto, K Kohno, M Kuwano and M Tsuneyoshi NEDD8 protein is involved in ubiquitinated inclusion bodies AD Kuazi, K Kito, Y Abe, R-W Shin, T Kamitani and N Ueda Letters to the Editor Book Reviews Announcements Volume Contents Volume 199, Number 3 March 2003 Review Article Apoptosis and melanoma: molecular mechanisms MR Hussein, AK Haemel and GS Wood Original Papers Concomitant expression of p16/NK4a and p14ARF in primary breast cancer and analysis of inactivation mechanisms J Silva, JM Silva, G Dominguez, JM Garcia, B Cantos, R Rodriguez, FJ Larrondo, M Provencio, P Espana and F Bonilla Loss of types XV and XIX collagen precedes basement membrane invasion in ductal carcinoma of the female breast PS Amenta, S Hadad, MT Lee, N Barnard, D Li and JC Myers Fluorescence lifetime imaging of unstained tissues: early results in human breast cancer PJ Tadrous, J Siegel, PMW French, S Shousha, E-N Lalani and GWH Stamp Increased expression of IgE-dependent histamine-releasing factor in endometriotic implants K Oikawa, Y Kosugi, T Ohbayashi, A Kameta, K Isaka, M Takayama, M Kuroda and K Mukai Expression of haem oxygenase in cirrhotic rat liver C-L Wei, K-H Lee, H-E Khoo and W-M Hon Early up-regulation of chemokine expression in fulminant hepatic failure L Leifeld, F-L Dumoulin, I Purr, K Janberg, C Trautwein, M Wolff, MP Manns, T Sauerbruch and U Spengler Determination of the molecular relationship between multiple tumour nodules in hepatocellular carcinoma differentiates multicentric origin from intrahepatic metastasis I Oi-lin Ng, X-Y Guan, RT-P Poon, S-T Fan and JM-F Lee ....345 Comparative molecular and histological grading of epithelial dysplasia of the oral cavity and the oropharynx MP Tabor, BUM Braakhuis, JE van der Wal, PJ van Diest, CR Leemans, RH Brakenhoff and JA Kummer Cross-reactivity of yeast antigens in human colon and peripheral leukocytes N Oshitani, F Hato, K Suzuki, Y Sawa, T Matsumoto, K Maeda, K Higuchi, S Kitagawa and T Arakawa Markers for the development of early prostate cancer MD Slater, C Lauer, A Gidley-Baird and JA Barden Leydig cell micronodules are a common finding in testicular biopsies from men with impaired spermatogenesis and are associated with decreased testosterone/LH ratio M Holm, E Rajpert-De Meyts, A-M Andersson and NE Skakkebzek = Sella hse saci csc ael roseletel oag Santino Seniors esae sc cde sid cleo aaa sac nceealeosasitaseniae acted 378 a-Actin isoform distribution in normal and failing human heart: a morphological, morphometric, and biochemical study AJH Suurmeijer, S Clement, A Francesconi, L Bocchi, A Angelini, DJ Van Veldhuisen, LG Spagnoli, G Gabbiani and A Orlandi .... sacitntinseabacieatniaianees The pancreatitis-associated protein induces lung inflammation in the rat through activation of TNFa expression in hepatocytes E Folch-Puy, A Garcia-Movtero, JL Iovanna, JC Dagorn, N Prats, MI Vaccaro and D Closa Book Reviews . Volume Contents April 2003 Volume 199, Number 4 Review Article The clinical evaluation of HER-2 status: which test to use? J Bartlett, E Mallon and T Cooke Original Papers Correlation between immunohistochemistry (HercepTest) and fluorescence in situ hybridization (FISH) for HER-2 in 426 breast carcinomas from 37 centres M Dowsett, J Bartlett, IO Ellis, J Salter, M Hills, E Mallon, AD Watters, T Cooke, C Paish, PM Wencyk and SE Pinder Expression of cyclins E, A, and B, and prognosis in lymph node-negative breast cancer H Kihling, P Alm, H Olsson, Ob FTE, Te I, Oe PINS CITI PIII ssc cetnscesesteciesiienssnurcsnsssoascansnausbovnvesnenaseivednsasiicaibausanhonieisinineatestsaddensenseKal 424 Maspin expression in invasive breast cancer: association with other prognostic factors SK Mohsin, M Zhang, GM Clark and DC Allred Absence of either gastric or intestinal phenotype in microscopic differentiated gastric carcinomas H Kawachi, T Takizawa, Y Eishi, S Shimizu, J Kumagai, N Funata and M Koike Epstein-Barr virus and microsatellite instability in gastric carcinogenesis MS Chang, HS Lee, HS Kim, SH Kim, SI Choi, Bs ee care nc Orne en PO I, 527 ccc cricinuionapeninmoneo cece beneiainncionsiin anaaania rss iassahaieeaiaaaeddaeamadidamvasaey .... 447 Progressive genomic alterations in intraductal papillary mucinous tumours of the pancreas and morphologically similar lesions of the pancreatic ducts D Soldini, M Gugger, E Burckhardt, A Kappeler, JA Laissue and L Mazzucchelli.............: 453 Low- and high-risk CIN 1 and 2 lesions: prospective predictive value of grade, HPV, and Ki-67 immuno-quantitative variables A-J Kruse, JPA Baak, EA Janssen, MGW Bol, K-H Kjellevold, B Fianne, K Lovslett and J Bergh ............cccccccceceeeeseseeeseeeeed 462 Abnormalities of E- and P-cadherin and catenin (f-, y-catenin, and p120°") expression in endometrial cancer and endometrial atypical hyperplasia G Moreno-Bueno, D Hardisson, D Sarrid, C Sanchez, R Cassia, J Prat, JG Herman, M Esteller, X Matias-Guiu and J Palacios Proteoglycans and WT1 as markers for distinguishing adenocarcinoma, epithelioid mesothelioma, and benign NO i cecisscscsimyinnidisusicnsiiunise berms sunieioatonnsedecbonaad.i csadliiotwiictvttaboaeatietede elxtae atanaatawekideddsbarudltesisteea el 479 Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes GA Stewart, GF Hoyne, SA Ahmad, E Jarman, VARE4 Witness, Ol Carvin, C Hamlett, die Lareils eieed SEIU PHRUEG nnicscceicccecssncessccscccsssecccccssscsssnesncccnsensensevivesivssonsnscesinsssnsinseesanl 488 Role for macrophage migration inhibitory factor in acute respiratory distress syndrome KN Lai, JCK Leung, CN Metz, FM Lai, R Bucala and HY Lan Different expression patterns of calpain isozymes 1 and 2 (CAPN1 and 2) in squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) of human skin J Reichrath, C Welter, T Mitschele, U Classen, V Meineke, W Tilgen and M Seifert 509 Elevated telomerase activity, c-MYC-, and hTERT mRNA expression: association with tumour progression in malignant lipomatous tumours R Schneider-Stock, C Boltze, V Jager, J Epplen, O Landt, B Peters, J Rys and A Roessner The haematopoietic specific signal transducer Vavl is expressed in a subset of human neuroblastomas I Hornstein, E Pikarsky, M Groysman, G Amir, N Peylan-Ramu and S Katzav Guanidine hydrochloride extraction and detection of prion proteins in mouse and hamster prion diseases by ELISA S-C Kang, R Li, C Wang, T Pan,T Liu, R Rubenstein, G Barnard, B-S Wong and M-S Sy Letter to the Editor Book Review Announcements