Volume 41, supl. 1, 2005 ISSN 1516-9332 Revista Brasileira de Ciências Farmacêuticas Brazilian Journal of Pharmaceutical Sciences 5th I C P S NTERNATIONAL ONGRESS OF HARMACEUTICAL CIENCES CIFARP 2005 Ribeirão Preto - São Paulo - Brasil September 25 - 28, 2005 Faculdade de Ciências Farmacêuticas Universidade de São Paulo R evista Brasileira de Ciências Farmacêuticas/ Brazilian Journal of Pharmaceutical Sciences, editada pela Faculdade de Ciências Farmacêuticas da Universidade de São Paulo, com Revista Brasileira de periodicidade trimestral, vem dar continuidade à “Revista de Farmácia e Bioquímica da Universidade de São Paulo”, cuja origem remonta aos “Anais de Farmácia e Odontologia da USP”, Ciências Farmacêuticas iniciada em 1939. The Revista Brasileira de Ciências Farmacêuticas/ Brazilian Journal of Pharmaceutical Sciences is edited quarterly by the Assinatura/Subscription College of Pharmaceutical Sciences, University of São Paulo Brazil Outside Brazil and was formerly known as the “Revista da Faculdade de Instituição/Institution R$ 260,00 US$ 80,00 Farmácia e Bioquímica da Universidade de São Paulo”, which has its origin in the “Anais de Farmácia e Odontologia da USP”, Individual/Private R$ 130,00 US$ 40,00 wich began in 1939. Doação/Gift Serviços de Informação/Information Services Somente para instituições públicas de ensino e pesquisa. A Revista Brasileira de Ciências Farmacêuticas/Brazilian Journal of Pharmaceutical Sciences é indexada nas seguintes Only to public teaching and research organizations. bibliografias: Analytical Abstracts, Chemical Abstracts, Excerpta Médica, International Pharmaceutical Abstracts, LILACS e Permuta/Exchange Nutrition Abstracts and Reviews. Com títulos de periódicos que sejam de interesse para o A Revista Brasileira de Ciências Farmacêuticas/ Brazilian Journal of Pharmaceutical Sciences is covered by the following acervo da Divisão de Biblioteca e Documentação bibliographies: Analytical Abstracts, Chemical Abstracts, Excerpta do Conjunto das Químicas. Médica, International Pharmaceutical Abstracts, LILACS and With those journals of interest to the Library Nutrition Abstracts and Reviews. of Conjunto das Químicas/USP. Comissão de Publicação/Editorial Board Secretaria de Edição/Editorial Office A Comissão de Publicação, responsável pelo estabelecimento Revista Brasileira de Ciências Farmacêuticas/ da política editorial da Revista, é constituída por quatro Brazilian Journal of Pharmaceutical Sciences membros, três deles eleitos pela Congregação da Faculdade Divisão de Biblioteca e Documentação de Ciências Farmacêuticas da Universidade de São Paulo. do Conjunto das Químicas da USP Serviço de Publicações e Circulação The Editorial Committee, which determines the Tel. (0XX11) 3091.3804 - Fax. (0XX11) 3097.8627 editorial policy of the Revista Brasileira de Ciências Caixa Postal 66083- CEP. 05315-970 - São Paulo - Brasil Farmacêuticas, consists of four members, three E-mail: [email protected] of whom are elected by the College of Pharmaceutical Sciences of the University of São Paulo. Ficha Catalográfica Versão on line/on line version Revista Brasileira de Ciências Farmacêuticas/Brazilian http//www.bcq.usp.br Journal of Pharmaceutical Sciences, São Paulo, v.35, n.1, (1999) – São Paulo: Faculdade de Ciências Farmacêuticas, USP, 1999- v., il.; 28cm. Trimestral Continuação de: Revista de Farmácia e Bioquímica da Universidade de São Paulo, v.8-34, 1970-1999. ISSN 1516-9332 1. Farmácia. I.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas 615 CDD September 25-28, 2005 Ribeirão Preto, SP, Brazil Promotion Co-Promotion Organization Revista Brasileira de Ciências Farmacêuticas Brazilian Journal of Pharmaceutical Sciences Revista Brasileira de Ciências Farmacêuticas v Organizer Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Brasil Rector: Prof. Dr. Adolpho José Melfi Vice-Rector: Prof. Dr. Hélio Nogueira da Cruz Pro-Rector of Research: Prof. Dr. Luiz Nunes de Oliveira Pro-Rector of Post Graduation: Profa. Dra. Suely Vilela Pro-Rector of Teaching: Profa. Dra. Sonia Teresinha de Souza Penin Pro-Rector of Culture & Extension Services: Prof. Dr. Adilson Avansi de Abreu Dean: Profª. Dra. Maria de Lourdes Pires Bianchi Vice-Dean: Prof. Dr. Augusto César C. Spadaro Organizing Commitee Prof. Dr. José Clovis do Prado Jr. Profª. Dra. Julieta Mieko Ueta Profª. Dra. Lúcia Helena Faccioli Prof. Dr. Luiz Fernando Lopes Guimarães Profª. Dra. Simone de Pádua Teixeira Scientific Commitee Prof. Dr. Auro Nomizo Profª. Dra. Maria José Vieira Fonseca Profª. Dra. Carem Gledes Vargas Recchia Profª. Dra. Maria Vitória Lopes Badra Bentley Prof. Dr. Gilberto Úbida Leite Braga Prof. Dr. Norberto Peporine Lopes Profª. Dra. Glória E. Petto Souza Profª. Dra. Patrícia Berardo Maia Campos Prof. Dr. José Clóvis do Prado Júnior Prof. Dr. Sérgio Akira Uyemura Profª. Dra. Julieta Mieko Ueta Profª. Dra. Simone de Pádua Teixeira Prof. Dr. Leonardo Régis Pereira Kassandra Azevedo Tadini (Graduate) Profª. Dra. Lúcia Helena Faccioli Mário Sérgio Pereira Marchesi (Undergraduate) Prof. Dr. Luis Fernando Lopes Guimarães Revista Brasileira de Ciências Farmacêuticas Brazilian Journal of Pharmaceutical Sciences Revista Brasileira de Ciências Farmacêuticas vi Parallel Events II Workshop on Education in Pharmaceutical Sciences Meeting of Graduate Program Coordinators in Pharmaceutical Sciences Coordinator Eliezer J. Barreiro - CAPES Representative Revista Brasileira de Ciências Farmacêuticas Brazilian Journal of Pharmaceutical Sciences Revista Brasileira de Ciências Farmacêuticas vii Support Vice Rectorate of Post Gaduation Vice Rectorate of Research Vice Rectorate of Culture and Extension Revista Brasileira de Ciências Farmacêuticas Brazilian Journal of Pharmaceutical Sciences Revista Brasileira de Ciências Farmacêuticas viii Scientific Program Lectures L01 Science and Technology Policies in health care Reinaldo F. N. Guimarães - Brazil L02 Quality assurance Claudia Coral - Brazil L03 Animal health in Brazil. How can pharmacists act?: Mitika K. Hagiwara - Brazil L04 Drug surveillance: diagnosis and perspectives Nair Ramos de Souza - Brazil L05 Structural changes and consequences in emulsions for topical Stig E. Friberg - USA applications L06 Planning of new candidates for chemical industries of Eliezer J. Barreiro - Brazil pharmaceutical interest with symbiotic profile L07 Home pharmacy Sotero Serrate Mengue - Brazil L08 Impact of stereoselectivity on the kinetic disposition and Vera Lanchote - Brazil metabolism of drugs L09 Molecular characteristics of Hepatitis C virus (HCV) core protein David Peabody - USA L10 Drug Development: Strategies for developing countries Gino Del Ponte - Brazil L11 Pharmaceutical assistance and the role of the official Tuyoshi Ninomya - Brazil pharmaceutical laboratories L12 The pharmacist in the context of pharmaceutical care in hospital Marcelo Gastaldi - Brazil L13 Adriamycin-induced mitochondrial cardiomyopathy Kendall Wallace - USA L14 Natural products as a resource for anticancer drugs Manoel Odorico Moraes - Brazil L15 Mitochondrial oxidative stress and atherogenesis: a possible connection Aníbal Eugênio Vercesi - Brazil L16 Disclosing the meanings embedded in pharmaceutical care practice Djenane Ramalho de Oliveira - Brazil L17 Cutaneous permeation of cosmetic ingredients in safety and efficacy studies Jean Paul Marty - France Revista Brasileira de Ciências Farmacêuticas Brazilian Journal of Pharmaceutical Sciences Revista Brasileira de Ciências Farmacêuticas ix L18 Safe medication practices Michael R. Cohen - USA L19 BIOTA/FAPESP - a model for research programs on the characterization, Ricardo Ribeiro Rodrigues - Brazil conservation and sustainable use of biodiversity L20 Extracts for phytomedicine and phytocosmetic market Lauro E. S. Barata - Brazil L21 Tailor made ruthenium nitrosyls as nitric oxide donors. Elia Tfouni - Brazil Symposia S1 Natural products S1.1 Biodiversity in the State of São Paulo as a powerful tool for a Vanderlan da Silva Bolzani - Brazil drug discovery integrated program S1.2 Institute of the Millennium: innovation and development in drugs João Luiz Callegari Lopes - Brazil and medicines S1.3 Biodiversity and pharmaceutical innovation: a new model for EXTRACTA Antonio Paes de Carvalho - Brazil S2 Advances in diagnosis and cancer therapy S2.1 Tumor angiogenesis and vascular development – Two Cláudia Oliveira Rodrigues - USA related processes? S2.2 Dendritic Cells: an effective tool in cancer immunotherapy José Alexandre M. Barbuto - Brazil S2.3 Microarray as a tool for cancer diagnosis and prognosis Helena Brentani - Brazil S3 Enzymes of pharmaceutical interest S3.1 Enzymes for food technology Gláucia Maria Pastore - Brazil S3.2 Enzyme therapies in the early years of the 21st century Michael Simon Nothenberg - Brazil S3.3 Enzymes in dermo-cosmetic and personal care products Suraia Said - Brazil S4 Atherosclerosis S4.1 Interfering with CD36 scavenger receptor function protects Sylvie Marleau - Canada apolipoprotein E- deficient mice from developing atherosclerotic lesions S4.2 Infectious agents and atherosclerosis Mário Hiroyuki Hirata - Brazil S4.3 Oxidative and nitrosative stress in atherosclerosis Dulcinéia Saes Parra Abdalla - Brazil S5 Pharmacogenetics and the use of medicines S5.1 Impacts on pharmacogenetics – searching for personalized prescriptions Eduardo Barbosa Coelho - Brazil S5.2 Pharmacogenetics in dyslipidemias Rosario Dominguez Crespo Hirata - Brazil S5.3 Pharmacogenetics, a functional approach: Nitric oxide example José Eduardo Tanus dos Santos - Brazil Revista Brasileira de Ciências Farmacêuticas Brazilian Journal of Pharmaceutical Sciences Revista Brasileira de Ciências Farmacêuticas x S6 Technological and biological aspects of drug delivery systems S6.1 Design of micro and nanoparticles delivery systems Osvaldo de Freitas - Brazil S6.2 Micro- and nanoparticulate drug delivery systems: a view on Maria Inês Ré - Brazil a process and product engineering S6.3 Micro- and nanostructured delivery systems and biological applications José Maciel Rodrigues Júnior - Brazil S7 Strategies for medication safety S7.1 A system-based approach to medication error reduction Michael R. Cohen - USA S7.2 Education of medical students to reduce prescribing errors Ajith Kumar Sankarankutty - Brazil S7.3 Studies on medication errors in Brazilian hospitals Silvia Helena de Bortoli Cassiani - Brazil S7.4 Data analyses of CPOE system for detection of potential adverse Daniel Fábio Kawano - Brazil drug event S8 Apoptosis S8.1 Mechanisms of cell death: cancer and the apoptotic machinery João G. P. Amarante-Mendes - Brazil S8.2 Pharmacological interference with the apoptosis machinery Fabíola Attié de Castro - Brazil S8.3 Cancer immunotherapy: On the TRAIL of a cure? Thomas S. Griffith - USA S9 Probiotics S9.1 Probiotics: current state and prospects Susana Marta Isay Saad - Brazil S9.2 Probiotics: studies from animal models and clinical trials Jacques Robert Nicoli - Brazil S9.3 Probiotics: application in clinical practice Carlos Daniel Magnoni - Brazil S10 Pathogeny and therapy of autoimmune illnesses mediated by immunocomplexes S10.1 Pathogenesis of diseases caused by immunocomplexes: Yara Maria Lucisano Valim – Brazil role of neutrophils S10.2 Experimental model for illnesses triggered by immunocomplexes Cleni Mara Marzocchi Machado - Brazil S10.3 Therapy of auto immune illnesses Eduardo Antônio Donadi - Brazil S11 Challenges of pharmaceutical care and clinical pharmacy S11.1 Pharmaceutical care: advances and national policy Norberto Rech - Brazil S11.2 Challenges and perspectives of clinical pharmacy Julieta Ueta - Brazil S11.3 Challenges to pharmaceutical care and clinical pharmacy Divaldo P. de Lyra Júnior - Brazil S11.4 Pratices in clinical pharmacy: an academic model Dílson Braz da Silva Jr - Brazil S12 Immune response modulation S12.1 The role of gangliosides in modulating the function of IgE receptors Constance Oliver - Brazil S12.2 New insights into signaling via IgE receptors David Holowka - USA S12.3 Functional glycomics - role of glycoconjugates in immunity and Richard Dale Cummings - USA development