European Academy of Andrology – Centre Report 2014 EAA ANDROLOGY CENTRE GIESSEN Directors: Prof. Dr. med. Wolfgang Weidner Department of Urology, Pediatric Urology and Andrology Rudolf-Buchheim-Straße 7 D-35385 Giessen, Germany Phone: +49 641 99 44501 Fax: +49 641 99 44509 E-Mail: [email protected] URL: http://www.uniklinikum-giessen.de/urol Prof. Dr. rer. physiol.Andreas Meinhardt Department of Anatomy and Cell Biology Division of Reproductive Biology Justus-Liebig-University of Giessen Aulweg 123 D-35385 Giessen, Germany Phone: +49 641 99 47024 Fax: +49 641 99 47029 E-Mail: [email protected] URL:http://www.uni-giessen.de/cms/fbz/fb11/institute/anatomie/forschung/ag-reproduktion 1 European Academy of Andrology – Centre Report 2014 Structure of the centre The EAA training centre Giessen consists of the following units: - Department of Urology, Paediatric Urology and Andrology (Head: Prof. W. Weidner) - Department of Anatomy and Cell Biology, Unit for Reproductive Biology (Head: Prof. A. Meinhardt) - Testicular Biopsy Repository, Department of Veterinary Anatomy, Histology and Embryology (Head: Prof. Bergmann) (together with Prof. HC. Schuppe, Urological Clinic) - Medical Department and Policlinic III –Endocrinology- (Head: Prof. Schäffler, cooperating partner: Prof. T. Linn) History of the centre The history of andrology at the University of Giessen goes back to 1951, when a working group for the study of male hypogonadism was founded by members of the Department of Internal Medicine, the Outpatient Clinic of Internal Medicine, the Clinic of Dermatology, and the Institute of Anatomy. A Department of Andrology at the Clinic of Dermatology at Giessen University was founded in 1968 and was changed into a Chair of Andrology and Venereology in 1980. In 1989 a new Chair of Dermatology and Andrology at the Clinic of Dermatology was taken over by W.-B. Schill. At the same time, a Study Group for Reproductive Medicine was established, consisting of additional members of the Department of Obstetrics and Gynaecology, a Working Group of Endocrinology, and the Veterinary Clinic. With the appointment of W. Weidner as Chairman of the Clinic of Urology in 1993, the Department of Urology joined the Study Group for Reproductive Medicine. In 1999, this network of collaborations was formally established as Hessian Centre of Reproductive Medicine. Moreover, both research and training activities were intensified in 1998, when the universities of Giessen and Marburg became hosts of a graduate research training group of the Deutsche Forschungsgemeinschaft (DFG) entitled “Cell-Cell-Interaction in Reproduction“. This programme was extended until 2005. In view of growing interest in clinical andrology and related basic research, the Andrology Centre has been extended to include the Medical Department and Policlinic III (Endocrinology), a certified European Training Centre for Endocrinology (U.E.M.S.), headed by Prof. Schaeffler, and the Unit of Reproductive Biology in the Department of Anatomy and Cell Biology, headed by Prof. A. Meinhardt. These structural changes of the centre were part of the re-evaluation process in 2003. Beginning in 2009, the faculty of the Justus-Liebig-University Giessen and the UKGM GmbH decided to transfer the whole scientific and clinical andrological activities of the Department of Dermatology and Andrology to the Department of Urology, Pediatric Urology and Andrology. With this consented decision, the new Department of Dermatology stopped the historical tradition to diagnose and to treat andrological patients. In detail, the clinical andrological outpatient department (Prof. Dr. H.-C. Schuppe), including the andrological laboratory, and the cryobanking facilities have been transferred, histopatholgical work-up and the resp. collections of testicular biopsies are now integrated in the Giessen testicular biopsy repository (Prof. M. Bergmann). 2 European Academy of Andrology – Centre Report 2014 Name and address of Centre Department of Urology, Paediatric Urology and Andrology Rudolf-Buchheim-Str. 7, 35592 Giessen, Germany Department of Anatomy and Cell Biology, Reproductive Biology Aulweg 123, 35392 Giessen, Germany Type of Centre University University Hospital X Private Centre Other (please specify) 1. Director Prof. Dr. Wolfgang Weidner (Co-chairs) 2. Director (if more Institutions in the Centre) Prof. Dr. Andreas Meinhardt (Co-chairs) 3. Present Staff (Senior Scientists) 1) Name Prof. Dr. W. Weidner Degree MD Speciality Urologist – Andrologist Academician X Affiliated Member Clinical Andrologist X 2) Name Prof. Dr. H.C. Schuppe Degree MD Speciality Dermatologist - Andrologist Academician X Affiliated Member Clinical Andrologist X 3) Name PD Dr. Th. Diemer Degree MD Speciality Urologist Academician applied Affiliated Member Clinical Andrologist X for Insert any additional staff below (if required) Prof. Dr. FM Wagenlehner (Specialist for urological infections) Dr. A. Hauptmann (Specialist for Peyronie’s disease and sexual dysfunction) Dr. A. Pilatz (Specialist for Prostatitis and urogenital infections, urosonography) All mentioned colleagues are specialists for Urology and have the German qualification - Andrological Urologist - . MD/Biologists/Chemists 1) Name Prof. Dr. Klaus Steger Degree Dr. rer. nat. Speciality Biology Full time/part time full time Academician Affiliated Member Clinical Andrologist 3 European Academy of Andrology – Centre Report 2014 2) Name Dr. Agnieszka Paradowska-Dogan Degree Dr. rer. physiol. Speciality Reproductive Biology Full time/part time full time Academician Affiliated Member X Clinical Andrologist 3) Name PD Dr. Undraga Schagdarsurengin Degree Dr. rer. nat. habil., Dipl. Biol. Speciality Biology, Genetics Full time/part time full time Academician Affiliated Member Clinical Andrologist 4) Name Dr. Temuujin Dansranjavin Degree Dr. rer. nat., Dipl. Biol. Speciality Biology Full time/part time full time Academician Affiliated Member Clinical Andrologist 5) Name Prof. Andreas Meinhardt (Co-chair of the EAA Center) Degree Dr. rer. nat. Speciality Biology Full time/part time full time Head of the Department of Anatomy and Cell Biology PhD Students and andrological trainees 2009-2014 1 Marconi, Marcelo Santiago de Chile MIDLEPLAN, Chile Clinical Andrologist 2007- 2009 2 Steilmann, Cornelia Giessen DFG KFO 181/1 PhD 2007- 2010 3 Cavalcanti, Marcia Brasilien DFG KFO 181/1 Researcher 2009- 2010 4 Bärmann, Birte Giessen UKGM PhD 2009- 2013 5 Vieweg, Markus Giessen DFG KFO181/2 PhD 2010- 2012 6 Yang, Yang Shanghai Stipendium University PhD 2010- Shanghai 2013 7 Steinfeld, Kai Tina Giessen DFG KFO 181/2 PhD 2010- 2014 8 Rusz, András EAA Center LOEWE- MIBIE, B1, B2 Urogenital infections for 2011- Budapest PhD thesis 2012 9 Gaurav, Sarode India DFG KFO 181/2 PhD 2011- 2014 10 Günther, Katharina Giessen KFO 181/2 Researcher 2012 11 Lengemann, Björn Department of Klinikum German Subspeciality 2012- Urology, Bad Bad Hersfeld Andrology in Urology 2013 Hersfeld 4 European Academy of Andrology – Centre Report 2014 12 Alidjanov, Jakhongir Tashkent Center of Urology, Research assistant 2013 Tashkent 13 Hartley, Ricardo Temuco PhD program ORCHID PhD 2013- Chile 2014 14 Menzel, Vivianna Giessen DFG KFO 181/2 Researcher 2013- 2014 15 Nessheim, Nils Giessen DFG KFO/2 PhD 2013- 2014 16 Velagala, Siva Reddy India IRTG (German PhD 2013- Research Foundation) 2015 17 Benelli, Andrea Department of University of Genua Clinical Andrologist (EAA) 2014- Urology, Genua 2015 18 Savadi-Shiraz, Elham Teheran IRTG (German PhD 2013- Research Foundation) 2015 19 Ni, Kai Shanghai Grant University PhD 2013- Shanghai 2016 20 Teubert, Lisa Giessen IRTG PhD 2014 21 Asmarinah, Draga Jakarta DAAD Project Researcher 2014 Nurses 7 nurses from the Dep. of Urology 1) Name are also integrated in the 2) Name andrological work-up, not separated for Andrology Laboratory Technicians (only for Andrology) 1) Name G. Hecker 2) Name S. Pinkl 3) Name B. Schuster 4) Name F. Schmidt 5) Name T. Bloch Administrative Personnel 1) Name Wolf, Julia (study nurse) 2) Name Conrad, Monika (chief secretary) 3) Name Oesterlein, Angelika 4) Name Endres, Katharina (DFG-research) 5) Name Buch-Heberling,Mareike(DFG- research) 6) Name M. Blazevic (Testicular repository, cryopreservation Insert any additional staff below (if required) Ottway, P. (lector, native english speaker) Hess, M. (graphical assistant) For each staff category please specify changes (increased or decreased since last EAA site visit Physicians Unchanged Increased X Decreased Please specify: more financial support 5 European Academy of Andrology – Centre Report 2014 Nurses Unchanged X Increased Decreased Please specify: more financial support Please specify Laboratory Technicians Unchanged Increased X Decreased Please specify: more financial support (grants) Please specify Administrative Personnel Unchanged Increased X Decreased Please specify: more financial support by the Please specify clinical organization (UKGM) Overall comment – is personnel staff enough for centres activities? Yes X No Further comment 4. Clinical Activity A. Outpatients: Consultations per year in the last 3 years 2012 2013 2014 New patients 1075 1218 1072 X Controls 943 1054 931 X X documented until 11/2014 Type of patients in the last years (%) 2012 2013 2014 Infertility not analysed not analysed 40% Erectile dysfunction “ “ 20% Hypogonadotropic Hypogonadism “ “ 5% Klinefelter “ “ 1% Gynaecomastia “ “ below 1% Varicocele “ “ 8% Cryptorchidism “ “ 5% Male sex accessory gland infections “ “ 12% Testicular tumours “ “ 2% Disorders of gender identity “ “ below 1% Other (e.g. ejaculatoy disorders, “ 5% “ peyronies disease) 6 European Academy of Andrology – Centre Report 2014 B. Ultrasound (testis, penile, prostate) 2012 2013 2014 total about 10.000 about 10.000 about 10.000 All patients coming to the Urological Department are undergoing threemonthly ultrasonography of the kindeys, bladder, scrotal content, penis shaft and prostate Controls (TRUS, if older than 50 years of age). Furthermore about 1.000 duplex investigations are done per year (erection test, varicocele reflux) Certification by the German Society of Ultrasonography, instructor Dr. B. Altiniklic) C. Andrological surgery procedures 2012 2013 2014 X 116 (as TESE, per 138 120 Testicular biopsies testicle) Varicocele ligation 25 19 38 Prostate biopsies More than 300 More than 300 More than 300 BPH (TURP, laser TURP) More than 120 More than 130 More than 100 Prostate cancer (RRP) 42 35 39 Vasectomy 17 18 18 Vaso-vasostomy 12 38 40 Other (MESA) 16 22 10 Other microsurgery (e.g. nerv- 2 4 2 dissection) Corporoplasty 44 40 39 Penile reconstruction and penile implants 6 9 6 Testicular cancer operations 29 30 25 X documented until 11/2014 5. A. Andrology laboratory activity 2012 2013 2014 Semen analyses 1222 1314 1242 X Sperm antibodies 390 632 590 X Seminal markers 2693 3591 3088 X X not finally documented 7 European Academy of Andrology – Centre Report 2014 5. B. Andrology laboratory activity Sperm banking donors Yes X No Sperm banking cancer patients (90%) Yes X No If yes: 2012 2013 2014 Number of samples 93 124 93 X X not finally documented 5. C. Histopathologial evaluation of biopsies Yes X No Biopsies: 2012: 986, 2013: 1164, 2014: 1010 (the testicular repository is run together with Prof. M. Bergmann, University of Giessen) 5. D. Reproductive Hormones Assays Yes X No If yes please specify type of assays and number of samples in the last year All infertility patients : Testosterone, FSH, LH, Prolactin All patients with sexual dysfunction: Testosterone, f-T, Estradiol, LH, Prolactin Special indications: T3, T4, TSH, inhibin, cortisol Are done in the Department of Endocrinology in cooperation (approx. 15.000 tests per year) 5. E. Y chromosome microdeletions according to Yes X No EAA/EMQN guidelines If yes number of tests in the past year 2012 not defined; 2013: 112; 2014: 108 Participation to the EAA quality control scheme? Yes No X If no, specify if available in another lab of the same hospital Yes X No - University Genetic Institute Blood karyotyping - University Genetic Institute Yes X No If no, specify if available in another lab of the same hospital Yes No Other genetic tests (CBAVD screening) in all patients with CBAVD undergoing MESA (University Genetic Institute) 6. Collaborations with other Clinical Units of the University/Hospital IVF Unit Yes X No University of Marburg, (Hospital Giessen-Marburg GmbH) If yes please specify: Children, Endocrinology, IVF, Urology, Genetics, Pathology 8 European Academy of Andrology – Centre Report 2014 Urology Clinic we are the Urology Clinic Yes No Endocrine Clinic Yes X No Genetics Lab/Unit Yes X No Paediatric Unit we run the paediatric urology Yes X No Central Hospital Laboratory Yes X No Private Centres for IVF Wetzlar, Wiesbaden, Offenbach, Yes X No Darmstadt, Frankfurt If yes please specify: 7. Clinical teaching activity Duration of training (years): 2 Number A: Trainees in the last five years 8 B: Trainees who passed EAA-ESAU\exam for Clinical Andrologist in the last 5yrs 1 C: Trainees working in the centre preparing to pass the EAA-ESAU examination 2 D: Ph D Students 14 E: Medical Students 4 F: Other students 5 P.S.: Generally attendance from other centers in Germany are not interested in the EAA qualification but mostly in the german subspeciality andrological urology. 8. Formal Andrology teaching program Yes X No If yes: specify duration (years/months): Years Months 18 Professional training Hours of formal teaching per year (weeks/months) Special program in english, Urological Clinic: integrated into the section - 2 hours daily (not on Friday) impaired fertility in men and - special consultation hours, operative animals - of the Giessen Graduate Medical Students theatre, ejaculate lab, cryobanking, School of the University of testicular histology, sonocourses, IVF Giessen (theoretical and scientific center, endocrinology background of Infertility) about 4- 6- hours per week Ph D Students same procedure same procedure Post Graduate students same procedure same procedure Trainees same procedure same procedure Other degrees (please specify) 9 European Academy of Andrology – Centre Report 2014 Further Training and Congress activities Reproductive medical Colloquium of the Hessian Centre of Reproductive Medicine (HZRM), the Clinical Research Unit 181 (Mechanisms of male factor infertility) and the International Research Training Group 1871 ‚Molecular Pathogenesis of Male Reproductive Disorders’ (IRTG), monthly 2007 Laboratory practice of the Giessen Graduate Centre of the Life Sciences (GGL) „Reproduction at Human and Animal“, since 2007 (Dr. A. Paradowska) Lecture Reproductive Medicine Giessen Graduate Centre of the Life Sciences (GGL), section „Reproduction at Human and Animal“: Operative Andrology, Sperm morphology – about old tales and new tools, Obesity and male reproductive function, since 2007 Spermiogramm-Erstellung und Auswertung. Intensivkurs der Deutschen Gesellschaft für Andrologie, (Prof. H.-C. Schuppe), Hamburg, 2009 Aufarbeitung von TESE-Material und Kryokonservierung. 52. Symposium der Deutschen Gesellschaft für Endokrinologie, (Prof. H.-C. Schuppe), Giessen, 2009 Ejakulatanalyse nach WHO: Neue Richtlinien und praktische Übungen in der Beurteilung der Morphologie. (Prof. H.-C. Schuppe), Fortbildungskurs Ejakulatanalyse, Bonn, 2009 Ejakulatdiagnostik nach WHO – Update 2009. DGRM School of Reproductive Medicine and Endocrinology, "Störungen der Spermatogenese: aktuelle interdisziplinäre Strategien", (Prof. H.-C. Schuppe), Regensburg, 2009 5th International Workshop "Molecular Andrology" – 1st Symposium of the Clinical Research Unit 181, "Stem Cells - Somatic Cells - Germ Cells", Organisation: A. Meinhardt, H.-C. Schuppe, J. Klug, Giessen, 2009 Urogenitale Infektion und Infertilität. Urologisches Winterforum Großhadern der LMU München, Großhadern am Tegernseee, (Prof. W. Weidner), 2010 EAA-Zentrum Giessen: Ejakulatdiagnostik nach WHO-Empfehlungen – Update 2010. Andrologische Labordiagnostik – Spermiogramm-Kurs in Kooperation mit der Deutschen Gesellschaft für Andrologie (Leitung: Prof. H.-C. Schuppe), Giessen, 2010 Andrologische Labordiagnostik – Spermiogramm-Kurs (in Kooperation mit der Deutschen Gesellschaft für Andrologie); Giessen, Leitung: Prof. Dr. H.-C Schuppe, 2010 1st German DFG Reproductive Science Network Meeting (KFO 181 Giessen/FOR 1041 Münster), Giessen. Organization: Prof. K. Steger (Giessen), 2010 DGRM School of Reproductive Medicine and Endocrinology / 16. Giessener Andrologisches Symposium und Intensivkurs der Deutschen Gesellschaft für Andrologie: „Kritische Andrologie in der interdisziplinären Reproduktionsmedizin“: Grenzen und Perspektiven, Leitung Prof. H.-C. Schuppe, Giessen, 2011 10