Artichoke Extract – Anti-cellulite Solution Artichoke better know as Cynara scolymus has been used in traditional medicine for centuries as a specific liver and gallbladder remedy. Artichoke is used to mobilize fatty stores in the liver and detoxify it, and as a natural aid to lower cholesterol. Cynarin demonstrated properties against oxidative stress induced by inflammatory mediators. In addition it exercises a certain control on lipolysis, favouring the synthesis energy-transporting enzymes NAD-NADH2 and NADP-NADPH2. It acts as diuretic and vasoconstrictor, stimulating the lymphatic drainage system. Artichoke mobilizes fat stores from the liver and other tissues such as white adipose tissue, and these fats pour into the blood from which they are subsequently excreted from the body. Indications - Oedematic Cellulite - Oedema - Localized fat - Scleroderma Side effects/ Contraindications None reported. Dermatitis following contact with the fresh plant and leaves has been reported. Artichoke has been documented in traditional uses to be hypoglycemic; however, no clinical studies have been published to confirm this action. Diabetics and people with hypoglycemia should use this plant product with caution and monitor their blood sugar levels closely in anticipation of these possible effects. Do not use during pregnancy and lactation. Presentation 2% - 5 ml ampoule – 0.176 fl. oz. References ∗ Betancor-Fernandez, A., et al. “Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity.” J. Pharm. Pharmacol. 2003; 55(7): 981-6. ∗ Wang, M., et al. “Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.).” J. Agric. Food Chem. 2003 Jan; 51(3): 601-8. ∗ Zapolska-Downar, D., et al. “Protective properties of artichoke (Cynara scolymus) against oxidative stress induced in cultured endothelial cells and monocytes.” Life Sci. 2002; 71(24): 2897. Asian Centella - Cellular Activation Solution Composition Centella asiatica, Fucus Vesiculosus extracts, Ivy extracts. Asian Centella helps in strengthening the capillaries and veins and assists with better blood circulation. It stops the formation of fibers that trap fat cells in cellulite and improve the flexibility of the connective tissue. Asian Centella, also known as Gotu Kola, stimulates collagen synthesis by energizing dermal fibroblasts, which leads to stronger blood vessel walls. Fucus contains iodines which regulate the metabolic or fat burning rate. It contains mucilage, a natural compound that removes excess body fluids and prevents fluid retention. The saponosides in the Ivy extract (Hedera helix) are natural surfactants. They releive congestion in the lymphatic system and make lipids soluble. Ivy helps the skin to better absorption of other present components. Waste products are removed from the tissue, fatty build-ups and deposits are released from the cells and present edemas are reabsorbed. This high antioxidant, anti-inflammatory and diuretic solution is strong cellulite fighter. Indications - Cellulite - Anti-ageing - Hypertrophic scars (keloids) - Skin ulcers - Post liposuction - Stretch marks - Venous insufficiency - Stria gravidarum - Wound healing (after burns, peelings, laser, surgery) - Venous disorders - Dermatitis - Hair loss Side effects/Contraindications Do not use during pregnancy and lactation. Presentation 2 ml ampoule – 0.07 fl. oz. References ∗ Cataldo, A., Gasbarro, V., et al, Effectiveness of the Combination of Alpha Tocopherol, Rutin, Melilotus, and Centella asiatica in The Treatment of Patients With Chronic Venous Insufficiency, Minerva Cardioangiol, 2001, Apr;49(2):159- 63. ∗ B. M. Hausen (1993) Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer Contact Dermatitis 29 (4), 175–179 doi:10.1111/j.1600-0536.1993.tb03532.x. ∗ Phytochemistry, 1978, 17:287 * Phytomedicine. 2000 Oct; 7(5):427-48. ∗ Aesthetic Plastic Surgery 24 (3): 227-234. ISSN: 0364-216X (Print) 1432-5241. ∗ Allegra C. Comparative Capillaroscopic Study of Certain Bioflavonoids and Total Triterpenic Fractions of Centella asiatica in Venous Insufficiency. Clin Ter. 1981; 99:507-13. ∗ Bartoletti CA, Gualtierotti R, Rota M, Tomaselli F, Circosta AM. Utilizzazione dell’estrato di centella asiatica nel trattamento della ‘cellulite’ edematosa degli arti inferiori. La Med Est 1983; 3: 97–103. Caffeine – Reducing Solution Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans, it can be found in cola nuts, coffee, tea, cacao beans, mate and other plants. Caffeine increases lipolysis by inhibiting the cyclic nucleotide phosphodiesterase, which is responsible for catalyzing the conversion of cyclic AMP to AMP. The resulting high tissue concentrations of cyclic AMP activate inactive hormone-sensitive lipase and promote lipolysis. It increases blood flow and stimulates the fat cells to release fat to the bloodstream to be burned by the body’s metabolism. Caffeine acts to drain the fat cells, tightens and tones the skin and helps to reduce the appearance of cellulite even more. In addition, caffeine acts as diuretics. The diuretic action helps to remove water from fat cells, thereby reducing their size. Indications - Localized fat - Cellulite Side effects/Contraindications Do not mix caffeine in any cocktail that contains Yohimbine. Caffeine is not recommended for individuals with heart conditions, and gastric ulcer disease. Caffeine can interact negatively with lithium. Do not use during pregnancy and lactation. Presentation 20% - 2 ml ampoule – 0.07 fl. oz. References ∗ Acheson KJ, Zahorska-Markiewicz B, Pittet Ph, Anantharaman K, Jéquier E. Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal and obese individuals. Am. J. Clin Nutr 1980; 33: 989–97. ∗ Bracco D, Ferrarra J-M, Arnaud MJ, Jéquier E, Schutz Y. Effects of caffeine on energy metabolism, heart rate and methylxanthine metabolism in lean and obese women. Am J Physiol 1995; 269: E671-8. ∗ Bellet S, Kershbaum A, Finck EM. Response of free fatty acids to coffee and caffeine. Metabolism 1968; 17: 702–7. DMAE – Firming Solution DMAE or Norcholine started to be used in external use to produce a lifting effect. It is a natural compound in our body. DMAE is a precursor of acetylcholine, a neuro-mediator which plays an important role in the skin. Keratinocytes, fibroblasts, myofibroblasts, sweat cells and endothelial cells, have membrane receptors and respond to acetylcholine. The tensile effect of DMAE results in a cholinergic stimulation of membrane receptors of fibroblasts, and stimulates progressive concentration of the myofilaments of its cytosol. DMAE also has antiradical and anti- lipofuscine activities and it repairs the proteinic cross linking (collagen and elastin). The mode of action of DMAE can consequently result a synergic combination of actions at different levels: tension of dermal non-muscle cells, cohesion and displacement of keratinocytes, hydratation and elasticity of the stratum corneum, better nutrition and skin defences, antioxidation and skin uniformation. It acts quickly and lasts long. Indications - Lifting - Flaccidity (tummy, arms, legs, etc.) - Sagging skin (body and face) - Neck folds Side effects/Contraindications Do not use during pregnancy and lactation. Presentation 3% - 5 ml ampoule – 0.7 fl. oz. References ∗ Morissette G, Germain L, Marceau F. The antiwrinkle effect of topical concentrated 2-dimethylaminoethanol involves a vacuolar cytopathology British Journal of Dermatology 156(3):433-439, 2007. ∗ Am J Clin Dermatol. 2005;6(1):39-47. Grossman R. Johnson and Johnson Consumer Products Worldwide, Skillman, NJ 08558. ∗ Skin Res Technol 2002 Aug; 8(3):164-7. ∗ Bjorksten, J. Crosslinkage and the aging process, in: Theoretical Aspects of Aging, by Morris Rockstein (ed), Academic Press, NY, 1974. Glutathione – Detoxifying Solution Glutathione (GSH) is a small molecule composed of 3 amino acids, cysteine, glutamic acid and glycine. It is a powerful antioxidant found within every cell protecting our cells from free radicals. Glutathione plays a role in nutrient the regulation of cellular events including gene expression, DNA and protein synthesis and repair, cell growth, and immune response, metabolism of toxins and carcinogens, enhancement of the immune system, and prevention of fat oxidation. It is involved in detoxification, binding itself to toxins such as heavy metals, chemical pollutants and carcinogens and transforming them into a form which can be easily flushed out of the body. The body produces and stores the largest amounts of GSH in the liver, where it is used to detoxify harmful compounds. GSH levels decline with age, and a lack of glutathione has been shown to leave the body more vulnerable to damage by free radicals, thus speeding up aging processes. Glutathione neutralizes damaging free radicals and peroxide molecules, and recharges oxidized vitamin C and E so that the body may reuse it. Glutathione has also been implicated in skin lightening. Studies show evidence of its involvement in the melanogenic pathway and its anti-melanogenic effect. Indications - Lifting - Skin rejuvenation - Melasma - Brown spots - Hyperpigmentations Side effects/Contraindications Do not use during pregnancy and lactation. Presentation 1% - 2 ml ampoule – 0.7 fl. oz. References * C. D. Villarama, H. I. Maibach. Glutathione as a depigmenting agent: an overview. International Journal of Cosmetic Science 2005, 27, 147-153. * M. Deveci, R.R. Gilmont, W.R. Dunham, B.P. Mudge, D.J. Smith, C.L. Marcelo. Glutathione enhances fibroblast collagen contraction and protects keratinocytes from apoptosis in hyperglycaemic culture. British Journal of Dermatology 2005, 152 , 217-224. * P. Drweski. Mesotherapy in Functional Anti-Aging Medicine. Anti-Aging Therapeutics, 9, 107-116. Glycolic Acid – Brightening Solution • Glycolic Acid is the most commonly used form of Alpha Hydroxy Acids (AHAs), which are a group of naturally occurring acids derived from certain plants and fruits. Glycolic Acid is considered to decrease the stratum corneum barrier and increase the penetration of topical agents, it works by stimulating new growth of skin and collagen and has an exfoliant action, once applied, glycolic acid reacts with the upper layer of the epidermis, weakening the binding properties of the lipids that hold the dead skin cells together. Furthermore it stimulates glycos-aminos-glycans like hyaluronic acid. The result is a much- smoother skin surface and a more youthful appearance. Another benefit is glycolic acid's ability to draw moisturizers into the newly-exfoliated skin surface. Glycolic Acid reduces the appearance of fine lines and wrinkles, age spots as well as improves sun-damaged skin. When used in combination with polyvitamins, Glycolic Acid is also useful for reducing stretch marks. AHAs also help to unclog pores and thus decrease the tendecy for acne to devolpe. A recent study indicated an additive inhibitory effect of glycolic acid on melanin synthesis through tyrosinase activity in melanoma cells, so it is effective for treatments of hyperpigmentations. Indications - Acne - Acne Scars - Blackheads/Whiteheads - Dry Skin, Sun-damaged Skin - Blotchy Pigmentation - Fine Wrinkles - Loss of Elasticity - Large Pores, Bumps - Age Spots/Dark Spots - Eczemac - Seborrheic Keratosis - Hyperkeratosis - Actinic keratosis Side effects/Contraindications Do not use during pregnancy and lactation. Presentation 1% - 2 ml ampoule – 0.07 fl. oz. * Cotellessa C, Peris K, Onorati MT, Fargnoli MC, Chimenti S. The use of chemical peelings in the treatment of different cutaneous hyperpigmentations. Dermatol Surg 1999; 25: 450–454. * Usuki A, Ohashi A, Sato H, Ochiai Y, Ichihashi M, Funasaka Y. The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells. Exp Dermatol 2003; 12: 43–50. * L. Atzori M.A. Brundu A. Orru P. Biggio. Glycolic acid peeling in the treatment of acne. Journal of the European Academy of Dermatology and Venereology 1999, 12, 119-122. * E. Bernstein, J. Lee, D. Brown, Rr Yu, E. Van Scott. Glycolic Acid Treatment Increases Type I Collagen mRNA and Hyaluronic Acid Content of Human Skin. Dermatologic Surgery 2001, 27, 429-433. Hyaluronic Acid – Wrinkle Smoothing Gel Hyaluronic acid is a non-sulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is plentiful in our bodies when we are born, but its levels gradually recede over time. This reduction in levels is a big part of the aging process. Hyaluronic acid is a jelly-like substance that fills the space between collagen and elastin fibers. The role of hyaluronic acid in skin is to provide a mechanism of transport of essential nutrients from the bloodstream to living skin cells, hydrate the skin by holding in water and act as a cushioning and lubricating agent against mechanical and chemical damage. It is capable of protecting the skin against ultraviolet irradiation due to its free radical scavenging properties. Indications - Wrinkles - Skin hydration - Wound healing Side effects/Contraindications Do not use during pregnancy and lactation. Presentation 3.5% - 5 ml phial 2% - 3 ml phial References ∗ Sakai S, Yasuda R, Sayo T, et al. Hyaluronan exists in the normal stratum corneum. J Invest Dermatol 2000; 114: 1184–1187. ∗ Ortonne JP. A controlled study of the activity of hyaluronic acid in the treatment of venous leg ulcers. J Dermatol Treatment 1996; 7: 75–81. ∗ Manuskiatti W, Maibach HI. Hyaluronic acid and skin: wound healing and aging. Int J Dermatol 1996; 35: 539–544. ∗ Trommer H, Wartewig S, Bottcher R et al. The effects of hyaluronan and its fragments on lipid models exposed to UV irradiation. Int J Pharm 2003; 254: 223–234. ∗ Duranti F, Salti G, Bovani B, Calandra M, Rosati ML. Injectable hyaluronic acid gel for soft tissue augmentation – a clinical and histological study. Dermatol Surg 1998; 24: 1317–1325. ∗ MB Brown, SA Jones (2005) Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin Journal of the European Academy of Dermatology and Venereology 19 (3), 308–318. L-Carnitine – Fat carrier Solution L-Carnitine exists naturally in the body and is an essential cofactor of acid metabolism of lipids. It attaches itself to long-chain acyl groups from fatty acids and carries them to the mitochondrial matrix (transmembrane transportation) so that they can be broken down in beta-oxidation to acetate to obtain usable energy via the citric acid cycle. L-Carnitine can remove the excess of acyl groups and has an antioxidant activity. L-Carnitine and acylcarnitines were also shown to be involved in reacylation and remodeling of membrane phospholipids and act as secondary antioxidants to protect cell membranes. Several studies demonstrated that L-Carnitine improves the body status of -tocopherol, a potent lipid-soluble antioxidant, protecting cellular membrane and plasma lipoproteins. It helps in the consumption and disposal of fat in the body because it is responsible for the transport of fatty acids from the cytosol into the mitochondria. Since the fat burning is such a major source of muscular energy, deficiencies in L- Carnitine are manifested as low energy levels and muscular weakness. Indications - Localized fat - Cellulite Side effects/Contraindications Do not use during pregnancy and lactation. Presentation 20% - 5 ml ampoule – 0.176 fl. oz. References ∗ J Med Food. 2006 Winter;9(4):468-73. ∗ J Biol Chem, Vol. 274, Issue 50, 35577-35582, December 10, 1999. ∗ Hoople C. The physiological role of carnitine. In: Ferrari R, DiMauro S, Sherwood G. eds. L-Carnitine and Its Role in Medicine: from Function to Therapy. Academic Press, London, 1992; 5–17. ∗ Kalaiselvi, T. & Panneerselvam, C. (1998) Effect of L-carnitine on the status of lipid peroxidation and antioxidants. J. Nutr. Biochem. 9:575-581. ∗ Dayanandan, A., Kumar, P. & Panneerselvam, C. (2001) Protective role of L-carnitine on liver and heart lipid peroxidation in atherosclerotic rats. J. Nutr. Biochem. 12:254-257. Organic Silica – Drainage & Regenerating Solution Silicium is a form of the chemical element silica that is thought to improve circulation and ensure the supply of blood even in cellulite tissues. It protects cells against free radicals and oxydation damage by combating lipid peroxidation, as well as stimulates the release of fat into the bloodstream. It is a structural component of the connective tissue, forming part of important macro- molecules as elastin and collagen. At this tissue level it induces the control and proliferation of fibroblasts and favours the regeneration of elastic and collagenous fibres. In the microcirculation, it modifies venous capillary and lymphatic permeability and, in the fatty tissue it stimulates cAMP synthesis as well as triglyceride hydrolysis. Silica stimulates and regulates fibroblast mitosis. The lack of silicium implies destructuring of connective tissue. Indications Due to its wide range of benefits, it is added to almost all cellulite, lipolysis, skin rejuvenation, hair loss, stretch marks and wound healing protocols. Side effects/Contraindications Do not use during pregnancy and lactation. Presentation 0.5% - 5 ml ampoule – 0.176 fl. oz. References ∗ Trabelsi, M. Trabelsi, M. Silanols: Organic Derivatives of Silicon Edi-Inter, 1997. ∗ Loepper, J. Research on the Role of Silica On Arterial Walls Biological Society, March 1961. ∗ Archives of Dermatological Research, Remodeling of the human dermis after application of salicylate silanol, Volume 299, Number 1 / April, 2007. Phosphatidylcholine – Lipolytic Solution Phosphatidylcholine is a liquid form of lecithin, which is an enzyme naturally produced in our body. It is the major component of all cell membranes and the lipoproteins that circulate in the blood. It plays an important role in intra and extra cellular metabolic transport by controlling what goes in and what comes out of the cell. Phosphatidylcholine facilitates the emulsification of fat into the tiniest particles, enabling the absorption and transportation of fat. After administration, phosphatidylcholine induces an enzymatic reaction, which leads to the dissolution of fat by producing an emulsion of nano- sized monoglycerides that is transported into the liver and metabolized by beta-oxidation. Lipolysis is not a replacement for plastic surgery but a very effective therapy to reduce smaller fat areas. Indications - Localized fat deposits and body contouring - Abdominal folds, upper arms, saddle bags, thighs, bottom, knees, back, waist and love handles - Lipomas - Liposuction correction Side effects/Contraindications Do not use during pregnancy and lactation. Presentation 5% - 5 ml ampoule – 0.176 fl. oz. References ∗ Lichtenberg D, Zilberman Y, Greenzaid P, Zamir S. Structural and kinetic studies on the solubilization of lecithin by sodium deoxycholate. Biochemistry 1979; 18: 3517-25. ∗ Hasengschwandtner F. The non surgical liposculpture J.of Cosm.Dermatology, 4-2005, 310-315. ∗ Myers P., The Cosmetic Use of Phosphatidylcholine in the Treatment of Localized Fat Deposits, Cosmetic Dermatology, June 2006, Vol. 19.NO 6. ∗ Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003; 27: 315-8.