Anti-VEGF Developments in Ophthalmology Vol. 46 Series Editors F. Bandello Milan W. Behrens-Baumann Magdeburg Anti-VEGF Volume Editors F. Bandello Milan M. Battaglia Parodi Milan Co-Editors A.J. Augustin Karlsruhe P. Iacono Rome R.O. Schlingemann Amsterdam U. Schmidt-Erfurth Vienna F.D. Verbraak Amsterdam 12 figures, 5 in color, and 13 tables, 2010 Basel · Freiburg · Paris · London · New York · Bangalore · Bangkok · Shanghai · Singapore · Tokyo · Sydney Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents® and Index Medicus. Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. 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No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. © Copyright 2010 by S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland) www.karger.com Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Reinhardt Druck, Basel ISSN 0250–3751 ISBN 978–3–8055–9529-2 e-ISBN 978–3–8055–9530-8 Library of Congress Cataloging-in-Publication Data Anti-VEGF / volume editors, Francesco Bandello, M. Battaglia Parodi ; co-editors, A. Augustin ... [et al.]. p. ; cm. -- (Developments in ophthalmology, ISSN 0250-3751 ; v. 46) Includes bibliographical references and indexes. ISBN 978-3-8055-9529-2 (hard cover : alk. paper) -- ISBN 978-3-8055-9530-8 (e-ISBN) 1. Eye--Blood-vessels--Diseases--Chemotherapy. 2. Vascular endothelial growth factors--Antagonists--Therapeutic use. I. Bandello, F. (Francesco) II. Battaglia Parodi, M. (Maurizio) III. Series: Developments in ophthalmology ; v. 46. 0250-3751 [DNLM: 1. Eye Diseases--therapy. 2. Vascular Endothelial Growth Factors--therapeutic use. 3. Neovascularization, Pathologic--therapy. W1 DE998NG v.46 2010 / WW 166 A6334 2010] RE720.A58 2010 617.7�061--dc22 2010025184 Francesco Bandello Department of Ophthalmology University Vita-Salute Scientific Institute San Raffaele Via Olgettina, 60 IT–20132 Milano (Italy) Maurizio Battaglia Parodi Department of Ophthalmology University Vita-Salute Scientific Institute San Raffaele Via Olgettina, 60 IT–20132 Milano (Italy) Section Title Contents VII List of Contributors IX Preface Bandello, F. (Milan) 1 Angiostatic and Angiogenic Factors de Groot, H.; Schmit-Eilenberger, V.; Kirchhof, J.; Augustin, A.J. (Karlsruhe) 4 Mechanisms of Ocular Angiogenesis and Its Molecular Mediators Siemerink, M.J. (Amsterdam); Augustin, A.J. (Karlsruhe); Schlingemann, R.O. (Amsterdam) 21 Antivascular Endothelial Growth Factors in Age-Related Macular Degeneration Schmidt-Erfurth, U.; Pollreisz, A.; Mitsch, C.; Bolz, M. (Vienna) 39 Antivascular Endothelial Growth Factor in Diabetic Retinopathy Iacono, P. (Rome); Battaglia Parodi, M.; Bandello, F. (Milan) 54 Retinal Vein Occlusions Buehl, W.; Sacu, S.; Schmidt-Erfurth, U. (Vienna) 73 Antivascular Endothelial Growth Factor for Choroidal Neovascularization in Pathologic Myopia Battaglia Parodi, M. (Milan); Iacono, P. (Rome); Bandello, F. (Milan) 84 Antivascular Endothelial Growth Factors for Inflammatory Chorioretinal Disorders Battaglia Parodi, M. (Milan); Iacono, P. (Rome); Verbraak, F.D. (Amsterdam); Bandello, F. (Milan) 96 Antivascular Endothelial Growth Factor Treatment in Pseudoxanthoma Elasticum Patients Verbraak, F.D. (Amsterdam) V VI Contents 107 Antivascular Endothelial Growth Factor in Hereditary Dystrophies Battaglia Parodi, M. (Milan); Iacono, P. (Rome); Bandello, F. (Milan) 111 Antivascular Endothelial Growth Factor as an Approach for Macular Edema Buchholz, P.M.; Buchholz, A.P.; Augustin, A.J. (Karlsruhe) 123 Angiogenesis and Vascular Endothelial Growth Factors in Intraocular Tumors Missotten, G.S. (Leuven/Amsterdam); Schlingemann, R.O. (Amsterdam); Jager, M.J. (Leiden) 133 Antivascular Endothelial Growth Factors in Anterior Segment Diseases Scholl, S.; Kirchhof, J.; Augustin, A.J. (Karlsruhe) 140 Author Index 141 Subject Index List of Contributors VII A.J. Augustin, Prof. Augenklinik Moltkestrasse 90 DE–76133 Karlsruhe (Germany) E-Mail