Alcohol and Hormones 8 • Substance Abuse During Pregnancy and Childhood, 1995 7· Alcohol, Cocaine, and Accidents, 1995 6 • Alcohol and Hormones, 1995 5 • Addictive Behaviors in Women, 1994 4 • Drug Abuse Treatment, 1992 3 • Alcohol Abuse Treatment, 1992 2 • Liver Pathology and Alcohol, 1991 1 • Drug and Alcohol Abuse Prevention, 1990 DDrruugg aanndd AAllccoohhooll AAbbuussee RReevviieewwss •• 66 AAlleeoohhooll aanndd HHoorrmmoonneess EEddiitteedd bbyy RRoonnaalldd RR.. WWaattssoonn UUnniivveerrssiittyy ooff AArriizzoonnaa,, TTuuccssoonn,, AArriizzoonnaa SSpprriinnggeerr SScciieennccee++66uussiinneessss MMeeddiiaa,, LLLLCC Copyright ©1995 Springer Science+Business Media New York Originally published by Humana Press Inc in 1995 Softcover reprint of the hardcover 1s t edition 1995 AII rights in any form whatsoever reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means (electronic, mechanical, photocopying, microfilming, recording, or otherwise) without written permission from the publisher. AII authored papers, comments, opinions, conclusions, or recommendations are those of the author(s), and do not necessarily reflect the views of the publisher. G This publication is printed on acid-free paper. ANSI Z39.48-1984 (American National Standards Institute) Permanence of Paper for Printed Library Materials. Photocopy Authorization Policy: Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Springer Science+Business Media, LLC., provided that the base fee of US $4.00 per copy, plus US $00.20 per page, is paid directly to the Copyright Clearance Center at 222 Rosewood Drive, Danvers, MA 01923. For those organizations that have been granted a photocopy license from the CCC, a separate system of payment has been arranged and is acceptable to Springer Science+Business Media, LLC. 10987654321 Library of Congress Cataloging-in-Publication Data Alcohol and hormones/edited by Ronald R. Watson. p. cm.-(Drug and alcohol abuse reviews) Includes index. ISBN 978-1-4612-6678-5 ISBN 978-1-4612-0243-1 (eBook) DOI 10.1007/978-1-4612-0243-1 1. Alcoholism-Endocrine aspects. 2. Alcohol-Pathophysiology. 1. Watson, Ronald R. (Ronald Ross) II. Series. RA 1242.A35A42 1995 616.86'107-dc20 94-38231 CIP Contents vii Preface ix Contributors 1 Pattern of Hormonal Response to Chronic Ethanol Ingestion During Puberty: Implication for Primary Effects on the Testicular Seminiferous Epithelium Robert A. Anderson, Jr. 21 Opioid-Mediated Control of Neuroendocrine Function: Role of K, j.l, and E Receptors Theodore J. Cicero and Michael L. Adams 49 Neuroendocrine Responses to Ethanol in the Prepubertal Female Rat w. Les Dees, Christopher L. Nyberg, and Jill K. Hiney 75 Involvement of Alcohol-Metabolizing Enzymes in Retinoic Acid Synthesis and Inhibition by Ethanol Gregg Duester 97 The Effect of Ethanol on Male Rodent Reproduction and Growth Mary Ann Emanuele, Margaret M. Halloran, John J. Tentler, Nicholas V. Emanuele, and Mark R. Kelley 127 Thyrotropin-Releasing Hormone (TRH): Clinical Neuroendocrine and Neurobehavioral Findings of Relevance to Alcoholism James C. Garbutt, Susan G. Silva, and George A. Mason v vi Contents 147 Hidden Hormones in Alcoholic Beverages: Ph ytoestrogens Judith S. Gavaler, Elaine R. Rosenblum, and Stephen R. Deal 161 Effects of TA-091 0, a Thyrotropin-Releasing Hormone Analog, on Alcohol Intake in Alcohol-Preferring Rats George A. Mason, Amir H. Rezvani, and James C. Garbutt 177 Gene Structure and Multiple Regulations of the Ethanol Inducible Cytochrome P4502E1 (CYP2E1) Subfamily Byoung-Joon Song 193 Thermoregulation and Alcohol Donald E. Spiers 209 Alcohol and the Release of Vasopressin and Oxytocin Alejandro M. Dopico, Jose R. Lemos, and Steven N. Treistman 227 Stress and Alcohol Wolfgang H. Vogel and Bradley D. Evans 245 Effect of Ethanol on Tyrosyl Phosphorylation of Growth Factor Receptor Substrates in the Liver Jack R. Wands, Kasibhatla Bhavani, and Yutaka Sasaki 261 Alcohol and Reproductive Hormones in Women Siew K. Teoh, Nancy K. Mello, and Jack H. Mendelson 279 Alcohol, Opioids, and Testicular Function Michael L. Adams and Theodore J. Cicero 295 Neuromodulatory Action of Opioid Peptides on Hypothalamic Neurons Jean-Pierre Wuarin and F. Edward Dudek 307 Interactions of Alcohol and Prostaglandins Carrie L. Randall, Jocelyn L. Saulnier, and Allen L. Salo 325 Effect of Alcohol on Growth Hormone-Related Liver Function and Sex Hormone Homeostasis Patricia K. Eagon and Pamela S. Lechner 337 Index Preface Alcoholism, the oldest addictive illness, remains a serious problem because of its major modifications of many physiological systems. The genetic and neurological origins and mechanisms are complex and only partly understood. However, it is clear that alcohol use modifies the production of most hormones, directly and indirectly modulating the systems that hormones regulate. Acute and chronic alcohol consumption affects virtually all cellular functions of tissues like brain, liver, immune system, and reproductive and endocrine organs. The latter have major regula tory roles, affecting many functions from development to repro duction. Although stress can further modify alcohol's effects on hormone production, it significantly causes most of alcohol's modi fications of the body to occur via changes in hormone production and secretion. Ronald R. Watson vii Contributors Michael L. Adams • Department of Psychiatry, Washington University School of Medicine, St. Louis, MO Robert A. Anderson, Jr. • Ob/Gyn Research, Rush-Presbyterian-St. Luke's Medical Center, Chicago,IL Kasibhatla Bhavani • Molecular Heptology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA Theodore J. Cicero • Department of Psychiatry, Washington University School of Medicine, St. Louis, MO Stephen R. Deal • Division of Women's Research, Oklahoma Transplantation Institute, Baptist Medical Center, and Oklahoma Medical Research Foundation, Oklahoma City, OK W. Les Dees· Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A & M University, College Station, TX Alejandro M. Dopico • Department of Pharmacology, University of Massachusetts Medical School, Worcester, MA F. Edward Dudek· Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, CO Gregg Duester • La Jolla Cancer Research Foundation, La Jolla, CA ix x Contributors Patricia K. Eagon • Veterans Affairs Medical Center; Departments of Medicine and Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA Mary Ann Emanuele • Departments of Medicine and Molecular and Cellular Biochemistry and the Molecular Biology Program, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL; Research and Medical Services, Department of Veteran Affairs Hospital, Hines, IL Nicholas V. Emanuele· Department of Medicine and the Molecular Biology Program, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL; Research and Medical Services, Department of Veteran Affairs Hospital, Hines, IL Bradley D. Evans • Psychiatrist, Tucson, AZ James C. Garbutt • Department of Psychiatry and Center for Alcohol Studies, and The Skipper Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, NC; Clinical Research Unit, Dorothea Dix Hospital, Raleigh, NC Judith S. Gavaler· Division of Women's Research, Oklahoma Transplantation Institute, Baptist Medical Center, and Oklahoma Medical Research Foundation, Oklahoma City, OK Margaret M. Halloran • Department of Molecular and Cellular Biochemistry, Stritch School of Medicine, Loyola University of Chicago, Maywood,IL Jill K. Hiney • Department of Veterinary Medicine and Public Health, College of Veterinary Medicine, Texas A & M University, College Station, TX Mark R. Kelley • Department of Pediatric Endocrinology, Indianapolis University Medical Center, Indianapolis, IN Contributors xi Pamela S. Lechner· Veterans Affairs Medical Center, and Departments of Medicine and Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA Jose R. Lemos • Neurobiology Group, Worcester Foundation for Experimental Biology, Shrewsbury, MA George A. Mason • Department of Psychiatry, Center for Alcohol Studies, the Skipper Bowles Center for Alcohol Studies, the Brain and Development Research Center, University of North Carolina at Chapel Hill, NC Nancy K. Mello • Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, Belmont, MA Jack H. Mendelson • Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, Belmont, MA Christopher L. Nyberg • Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A & M University, College Station, TX Carrie L. Randall • Department of Psychiatry and Behavioral Sciences and Department of Physiology, Medical University of South Carolina, Charleston, SC; Veterans Administration Medical Center, Charleston, SC Amir H. Rezvani • The Skipper Bowles Center for Alcohol Studies and the Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC Elaine R. Rosenblum. Division of Women's Research, Oklahoma Transplantation Institute, Baptist Medical Center, and Oklahoma Medical Research Foundation, Oklahoma City, OK