SERIES EDITORS KARL MARAMOROSCH Rutgers University, New Jersey, USA AARON J. SHATKIN Center for Advanced Biotechnology and Medicine, New Jersey, USA FREDERICK A. MURPHY University of Texas Medical Branch, Texas, USA ADVISORY BOARD DAVID BALTIMORE ROBERT M. CHANOCK PETER C. DOHERTY H. J. GROSS B. D. HARRISON BERNARD MOSS ERLING NORRBY J. J. SKEHEL M. H. V. VAN REGENMORTEL Academic Press is an imprint of Elsevier 32 Jamestown Road, London, NW1 7BY, UK Radarweg 29, PO Box 211, 1000 AE Amsterdam, The Netherlands 225 Wyman Street, Waltham, MA 02451, USA 525 B Street, Suite 1900, San Diego, CA 92101-4495, USA First edition 2011 Copyright # 2011 Elsevier Inc. All Rights Reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopy- ing, recording or otherwise without the prior written permission of the publisher Permissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone: (þ44) (0) 1865 843830, fax: (þ44) (0) 1865 853333; e-mail: