92ND ANNUAL MEETING June 16-19, 2016 The Hyatt Regency Baltimore on the Inner Harbor American Association of Neuropathologists AANP AMERICAN ASSOCIATION OF NEUROPATHOLOGISTS, INC. June 16 - 19, 2016 Hyatt Regency at the Inner Harbor Baltimore, Maryland This activity is provided by the American Association of Neuropathologists. 1 | Pag e TABLE OF CONTENTS President’s Welcome ................................................................................................................ 3 Save the Date ............................................................................................................................ 4 AANP Organization.................................................................................................................... 5 Committees ............................................................................................................................... 6 CME Information ....................................................................................................................... 7 Disclosure Information ............................................................................................................. 9 General Information .............................................................................................................. 11 Sponsors and Donors .............................................................................................................. 13 Hyatt Regency Floor Plans ...................................................................................................... 14 Meeting at a Glance ................................................................................................................ 15 Thursday Special Course ......................................................................................................... 19 Biographies and Presentation Information ................................................................. 20 Overview: Scientific Sessions .................................................................................................. 32 Friday Platforms 1-4 (Abstracts 1-32) ......................................................................... 33 Friday Posters (Abstracts 33-88) ................................................................................. 35 Saturday Platforms 5-8 (Abstracts 89-120) ................................................................ 36 Saturday Posters (Abstracts 121-178) ........................................................................ 40 Endowed Lectureships ............................................................................................................ 43 Parisi Lecture ............................................................................................................... 44 DeArmond Lecture ...................................................................................................... 47 Saul R. Korey Lecture ................................................................................................... 50 Matthew T. Moore Lecture ......................................................................................... 54 Meritorious Awards ................................................................................................................ 56 Diagnostic Slide Session .......................................................................................................... 59 Sunday Presidential Symposium ............................................................................................. 71 Biographies and Presentation Information ................................................................. 72 Notes ....................................................................................................................................... 80 2 | Pa g e The American Association of Neuropathologists, Inc. 5575 S. Sycamore St., Suite 235 Littleton, Colorado 80120 Phone: 720-372-0888; Fax: 303-568-0406 Email: [email protected] Dear Colleagues: I would like to personally welcome each of you to the 92nd Annual Meeting of the American Association of Neuropathologists. It’s an exciting time for AANP as we continue to grow and adapt, remaining always curious, motivated and responsive. It is important to meet and bring inspired people together in forums like this, to ensure our association remains at the cutting edge. I’d like to give you an idea of what you can expect over the next few days. This year’s meeting application (www.eventmobi.com/aanp2016) outlines a scheduled program of events that encompasses a wide variety of relevant topics, ranging from frontotemporal dementia to TBI in the military population. By the end of this year’s annual meeting, we hope to cite new information on the underlying causes and mechanisms of neurologic diseases, discuss research findings related to genetics and molecular mechanisms to better understand disorders of brain neoplasia, CNS trauma, and neurodegeneration, and incorporate new knowledge into improving everyday clinical practice and teaching of neuropathology. Thank you for attending our conference and bringing your expertise to our gathering. Throughout this conference, I ask you to stay engaged, keep us proactive, and help us shape the future of neuropathology. My personal respect and thanks goes out to all of you. Sincerely, Suzanne Z. Powell, MD President The American Association of Neuropathologists 3 | Pag e Save the Date! 93RD ANNUAL MEETING June 8-11, 2017 / Hyatt Regency Orange County 94TH ANNUAL MEETING June 7-10, 2018 / Hyatt Regency Louisville 95TH ANNUAL MEETING June 6-9, 2019 / Grand Hyatt Atlanta All meetings to be held the second weekend of June American Association of Neuropathologists AMERICAN ASSOCIATION OF NEUROPATHOLOGISTS AANP OFFICE 5575 S. Sycamore St., Suite 235, Littleton, CO 80120 Phone: 720-372-0888; Fax: 303-568-0406 Email: [email protected] OFFICERS Suzanne Z. Powell, MD, Houston Methodist Hospital System, President Matthew P. Frosch, MD, PhD, Harvard-MIT Health Sciences and Technology, Vice President Kathy L. Newell, MD, University of Kansas, Vice President for Professional Affairs Karen M. Weidenheim, Montefiore Medical Center, Secretary-Treasurer R. Ross Reichard, MD, Mayo Clinic, Assistant Secretary-Treasurer OTHER EXECUTIVE COUNCIL MEMBERS Arie Perry, University of California San Francisco, President-Elect Cheryl A. Palmer, University of Utah, Vice President-Elect Daniel J. Brat, MD, PhD, Emory University School of Medicine Raymond A. Sobel, MD, Stanford University School of Medicine Charles L. White III, MD, University of Texas Southwestern Medical School Eileen H. Bigio, MD, Feinberg School of Medicine, Northwestern University Anthony T. Yachnis, MD, University of Florida College of Medicine Thomas J. Montine, MD, PhD, University of Washington ARCHIVIST Michael N. Hart, MD, University of Wisconsin School of Medicine OFFICIAL JOURNAL Journal of Neuropathology and Experimental Neurology Raymond A. Sobel, MD, Editor-in-Chief Eileen S. Healy, Managing Editor E-mail: [email protected] Home page: http://www.jneuropath.com DIAGNOSTIC SLIDE SESSION Caterina Giannini, MD, PhD and Rebecca Folkerth, MD, Managers 5 | Pag e AANP COMMITTEES Awards Committee Constitution Committee Program Committee Sandra Camelo-Piragua, MD (Chair) Amyn Rojiani, MD, PhD (Chair) Sriram Venneti, MD, PhD (Chair) Jennier Baccon, MD, PhD Steven Carroll, MD, PhD Fausto Rodriguez, MD Ewa Borys, MD Andreana Rivera, MD Thomas Beach, MD Mark T. Curtis, MD, PhD Ivana Delalle, MD Cynthia Hawkins, MD, PhD Councilors to the International Charles Specht, MD Cheng-Ying Ho, MD, PhD, FRCPC Society of Neuropathology Miguel Guzman, MD Kyle Hurth, MD, PhD Alexander Judkins, MD Mike Lawlor, MD Jamie Jacobsohn, MD Arie Perry, MD Adenkunle Adesina MD, PhD Julia Kofler, MD Han Lee, MD Arnulf H. Koeppen, MD Mirna Lechpammer, MD, PhD E. Tessa Hedley-Whyte, MD Anne Hiniker, MD, PhD Norman L. Lehman, MD, PhD Goerge Perry, PhD Richard Perrin, MD, PhD James W. Mandell, MD, PhD Julie Kofler, MD Maria Martinez-Lage Alvarez, MD Amanda Fisher-Hubbard, MD Membership Committee Rupal Mehta, MD Michelle Madden Felicella, MD Murat Gokden, MD (Chair) Carrie Ann Mohila, MD Brent Orr, MD, PhD Leslie A. Bruch, MD Hilary Highfield Nickols, MD, PhD Christine E. Fuller, MD Richard Perrin, MD, PhD Website Committee (Ad Hoc of Peter Pytel, MD Edward Plowey, MD, PhD Joshua Sonnen, MD Professional Affairs) Matija Snuderl, MD Roberta Seidman, MD Douglas Anthony, MD, PhD (Chair) Joshua Sonnen, MD Bret Mobley, MD John Crary, MD, PhD Luis F. Gonzalez-Cuyar, MD Education Committee Nominating Committee Jingxin Qiu, MD, PhD R. Ross Reichard, MD (Chair) Thomas J. Montine, MD, PhD (Chair) Henry G. Brown, MD, PhD Maria Martinez-Lage Alvarez, MD Anthony T. Yachnis, MD Sonika Dahiya, MD Cindy Welsh, MD Charles L. White III, MD Kar-Ming Fung, MD, PhD Jane Uyehara-Lock, MD Raymond A. Sobel, MD Charles L. White, III, MD Jack Lee, MD, PhD William McDonald, MD Charles L. White III, MD Professional Affairs Committee Mark Cohen, MD Edward Lee, MD Kathy L. Newell, MD (Chair) Murat Gokden, MD Jesse Kresak, MD Brian E. Moore, MD Edward Lee, MD Gabrielle A. Yeaney, MD Robert E. Mrak, MD, PhD Brian Moore, MD Quinwen Mao, MD, PhD Marie Rivera Zengotita, MD Hilary Nickols, MD Anat Stemmer-Rachamimov, MD Eileen H. Bigio, MD Jennifer Baccon, MD Dan J. Brat, MD, PhD William H. Yong, MD Mariarita Santi-Vicini, MD, PhD Steven Dubner, MD Doug Anthony, MD, PhD Bradley Miller, MD, PhD 6 | Pa g e CME INFORMATION TARGET AUDIENCE The educational design of AANP’s Annual Meeting addresses the needs of physicians and scientists in the field of neuropathology who are involved in the diagnosis and/or treatment of patients with neurological disorders. STATEMENT OF NEED The purpose of this activity shall be to advance medical and scientific knowledge, understanding, and competence in the practice of neuropathology. The practice of neuropathology is understood to include diagnosis of diseases of the nervous system, scientific investigation into their causes, and teaching of neuropathology principles to colleagues and trainees. LEARNING OBJECTIVES Upon completion of this activity, participants should be able to: I. Cite new information on the underlying causes and mechanisms of neurologic diseases. II. Discuss research findings related to genetics and molecular mechanisms to better understand disorders of brain neoplasia, CNS trauma, and neurodegeneration. III. Incorporate new knowledge into improving everyday clinical practice and teaching of neuropathology. DISCLAIMER Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented is this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. PHYSICIAN ACCREDITATION STATEMENT The American Association of Neuropathologists is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. PHYSICIAN CREDIT DESIGNATIONS The American Association of Neuropathologists designates this live educational activity for a maximum of 24.50 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity. 7 | Pag e CME INFORMATION (Continued) CME CREDIT Instructions to Receive Credit In order to receive credit for this activity, the participant must complete the CME evaluations and credit applications for sessions attended, which are made available through the AANP Meeting App (http://eventmobi.com/aanp2016). The chart below outlines which sessions are offered for CME credit and the maximum number of credit hours a physician can earn for each educational activity being certified for AMA PRA Category 1 CreditTM at this year’s Annual Conference. Activity CME Credit Hours Special Course 6.75 Scientific Sessions 8 Korey Lecture 1 DeArmond Lecture 1 Parisi Lecture 1 Moore Lecture 1 Diagnostic Slide Session 3 Presidential Symposium 2.75 Total 24.5 For any questions regarding the accreditation of this meeting, please contact AANP’s CME Coordinator, Sarah Schott, via e-mail at: [email protected], or via phone at: 303-557-0859 x84. 8 | Pa g e DISCLOSURE INFORMATION Disclosure of Commercial Support: “In-kind” support through the donation of microscopes is being provided by Morrell Instruments. Disclosure of Unlabeled Use: This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The American Association of Neuropathologists does not recommend the use of any agent outside of the labeled indications. The opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. Disclosure of Conflict of Interest: The American Association of Neuropathologists requires instructors, planners, managers and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by AANP for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. Complete disclosure information will be provided to learners on-site. Planners and Managers The following planners and managers have nothing to disclose: Adenkunle Adesina, Doug Anthony, Jennifer Baccon, Eileen Bigio, Dan Brat, Sandra Camelo-Piragua, Ivana Delalle, Steven Dubner, Amanda Fisher-Hubbard, Matthew Frosch, Miguel Guzman, Anne Hiniker, Craig Horbinski, Eric Huang, Alexander Judkins, Julia Kofler, Jesse Kresak, Edward Lee, Han Lee, Michelle Madden Felicella, Quinwen Mao, Maria Martinez-Lage, Rupal Mehta, Thomas Montine, Brian Moore, Robert Mrak, Peter Nelson, Kathy Newell, Brent Orr, Cheryl Palmer, Richard Perrin, Arie Perry, Edward Plowey, Suzanne Powell, Peter Pytel, R. Ross Reichard, Marie Rivera Zengotita, Fausto Rodriguez, Mariarita Santi-Vicini, Raymond Sobel, Charles Specht, Susan Staugaitis, Anat Stemmer-Rachamimov, Mario Suva, Jane Uyehara-Lock, Sriram Venneti, Karen Weidenheim, Cindy Welsh, Charles White III, Anthony Yachnis, Gabrielle Yeaney, William Yong The following planners/managers reported the following financial relationships or relationships to products or devices they or their spouse/ partner have with commercial interests related to the content of this CME Activity. Thomas Beach Consultant/Independent Contractor: GE Healthcare, Avid Radiopharmaceuticals Grant/Research Support: Navidea Biopharmaceuticals, Avid Radiopharmaceuticals, Janssen Research and Development Michael Lawlor Consultant/Independent Contractor: Sarepta Therapeutics Grant/Research Support: Audentes Therapeutics, Solid GT Honoraria: Audentes Therapeutics Other: Scientific Advisory Board Member – Audentes Therapeutics Jack Lee Consultant/Independent Contractor: UpToDate Other: Joint Patents with Corenelli Consulting and others - Drug for AD and anti-anxiety effects Bradley Miller Stock Shareholder: Eli Lilly and Company Other: Eli Lilly and Company 9 | Pag e